KEGG   DRUG: D00777Help
Entry
D00777                      Drug                                   

Name
Amantadine hydrochloride (JP16/USP);
Symmetrel (TN)
Product
  Generic
AMANTADINE HYDROCHLORIDE (A-S Medication Solutions LLC), AMANTADINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), AMANTADINE HYDROCHLORIDE (American Health Packaging), AMANTADINE HYDROCHLORIDE (American Health Packaging), AMANTADINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), AMANTADINE HCL (AvKARE), AMANTADINE HCL (AvPAK), AMANTADINE HCL (Banner Pharmacaps), AMANTADINE HCL (Bryant Ranch Prepack), AMANTADINE HYDROCHLORIDE (Carilion Materials Management), AMANTADINE HYDROCHLORIDE (Carolina Medical Products Company), AMANTADINE HYDROCHLORIDE (Hi-Tech Pharmacal), AMANTADINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), AMANTADINE HYDROCHLORIDE (Lannett Company), AMANTADINE HYDROCHLORIDE (Mikart), AMANTADINE HYDROCHLORIDE (Morton Grove Pharmaceuticals), AMANTADINE HYDROCHLORIDE (Mylan Institutional), AMANTADINE HYDROCHLORIDE (Mylan Institutional), AMANTADINE HYDROCHLORIDE (NCS HealthCare of KY), AMANTADINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), AMANTADINE HYDROCHLORIDE (Pharmaceutical Associates), AMANTADINE HYDROCHLORIDE (Physicians Total Care), AMANTADINE HYDROCHLORIDE (Physicians Total Care), AMANTADINE HCL (Preferred Pharmaceuticals), AMANTADINE HYDROCHLORIDE (Qualitest Pharmaceuticals), AMANTADINE HYDROCHLORIDE (REMEDYREPACK), AMANTADINE HCL (Rebel Distributors Corp.), AMANTADINE HYDROCHLORIDE (STAT RX USA LLC), AMANTADINE HYDROCHLORIDE (Sandoz), AMANTADINE HYDROCHLORIDE (Upsher-Smith Laboratories), AMANTADINE HYDROCHLORIDE (Upsher-Smith Laboratories), AMANTADINE HYDROCHLORIDE (Upsher-Smith Laboratories)
Formula
C10H17N. HCl
Exact mass
187.1128
Mol weight
187.7096
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiviral, Antiparkinsonian [DS:H00057 H00398]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Adamantane derivative
Target
Influenza A M2 proton channel blocker [VG:NC_004907_1 NC_002016_1 NC_007367_1 NC_007377_1 NC_007363_1];
N-methyl-D-aspartate receptor antagonist [HSA:2902 2903 2904] [KO:K05208 K05209 K05210]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse  
 
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
Drug interaction
Structure map
Antiviral agents
Antiparkinsonian agents
N-Metyl-D-aspartic acid receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BB Adamantane derivatives
     N04BB01 Amantadine
      D00777  Amantadine hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Antiparkinson Agents, Other
   Amantadine
    D00777  Amantadine hydrochloride (JP16/USP)
 Antivirals
  Anti-influenza Agents
   Amantadine
    D00777  Amantadine hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1161  Amantadines
     D00777  Amantadine hydrochloride (JP16/USP)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-influenza agents
   Uncoating inhibitor
    influenza A M2 proton channel blocker
     Amantadine
      D00777  Amantadine hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00777  Amantadine hydrochloride
BRITE hierarchy
Other DBs
CAS: 
665-66-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        12
            1   C1z C    26.1041  -16.1171
            2   C1x C    25.0596  -16.7181
            3   C1x C    25.4857  -17.5815
            4   C1x C    27.1483  -16.7181
            5   N1a N    26.1098  -14.9037
            6   C1y C    25.0596  -17.9199
            7   C1y C    25.4857  -18.6958
            8   C1y C    27.1483  -17.9199
            9   C1x C    23.7761  -19.1627
            10  C1x C    26.1041  -18.5267
            11  C1x C    26.6408  -19.7694
            12  X   Cl   29.9600  -17.4300
BOND        13
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     6   9 1
            9     6  10 1
            10    7  11 1
            11    7   9 1
            12    8  10 1
            13    8  11 1

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