KEGG   DRUG: D00778Help
Entry
D00778                      Drug                                   

Name
Benztropine mesilate (JAN);
Benztropine mesylate (USP);
Cogentin (TN)
Product
  Generic
BENZTROPINE MESYLATE (Akorn), BENZTROPINE MESYLATE (American Health Packaging), BENZTROPINE MESYLATE (American Regent), BENZTROPINE MESYLATE (Aphena Pharma Solutions - Tennessee), BENZTROPINE MESYLATE (Bayshore Pharmaceuticals), BENZTROPINE MESYLATE (Bryant Ranch Prepack), BENZTROPINE MESYLATE (Bryant Ranch Prepack), BENZTROPINE MESYLATE (Camber Pharmaceutical), BENZTROPINE MESYLATE (Cardinal Health), BENZTROPINE MESYLATE (Cardinal Health), BENZTROPINE MESYLATE (Cardinal Health), BENZTROPINE MESYLATE (Clinical Solutions Wholesale), BENZTROPINE MESYLATE (Contract Pharmacy Services-PA), BENZTROPINE MESYLATE (Corepharma LLC.), BENZTROPINE MESYLATE (Dispensing Solutions), BENZTROPINE MESYLATE (Excellium Pharmaceutical), BENZTROPINE MESYLATE (Major Pharmaceuticals), BENZTROPINE MESYLATE (McKesson Contract Packaging), BENZTROPINE MESYLATE (McKesson Contract Packaging), BENZTROPINE MESYLATE (NCS HealthCare of KY), BENZTROPINE MESYLATE (NCS HealthCare of KY), BENZTROPINE MESYLATE (Nexus Pharmaceuticals), BENZTROPINE MESYLATE (PD-Rx Pharmaceuticals), BENZTROPINE MESYLATE (Pliva), BENZTROPINE MESYLATE (Qualitest Pharmaceuticals), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (Rebel Distributors Corp), BENZTROPINE MESYLATE (Rising Pharmaceuticals), BENZTROPINE MESYLATE (State of Florida DOH Central Pharmacy), BENZTROPINE MESYLATE (State of Florida DOH Central Pharmacy), BENZTROPINE MESYLATE (State of Florida DOH Central Pharmacy), BENZTROPINE MESYLATE (State of Florida DOH Central Pharmacy), BENZTROPINE MESYLATE (State of Florida DOH Central Pharmacy), BENZTROPINE MESYLATE (Upsher-Smith Laboratories), BENZTROPINE MESYLATE (West-Ward Pharmaceutical Corp)
Formula
C21H25NO. CH4SO3
Exact mass
403.1817
Mol weight
403.535
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiparkinsonian
Remark
ATC code: 
Drug group: 
Comment
Benztropine is called Benzatropine in INN.
Target
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Structure map
Antiparkinsonian agents
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AC Ethers of tropine or tropine derivatives
     N04AC01 Benzatropine
      D00778  Benztropine mesilate (JAN); Benztropine mesylate (USP)
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Anticholinergics
   Benztropine
    D00778  Benztropine mesilate (JAN); Benztropine mesylate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Benzatropine
      D00778  Benztropine mesilate (JAN); Benztropine mesylate (USP)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from ornithine
   Tropane alkaloids
    D00778  Benztropine mesilate (JAN); Benztropine mesylate (USP)
BRITE hierarchy
Other DBs
CAS: 
132-17-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   S4a S    33.2140  -18.8297
            2   C1a C    31.8828  -18.8243
            3   O1d O    34.5508  -18.8297
            4   O1d O    33.2084  -17.4986
            5   O1d O    33.2084  -20.1610
            6   C1x C    20.7530  -17.8020
            7   C1x C    21.0706  -16.6678
            8   C1y C    21.8872  -17.5298
            9   C1y C    22.2047  -16.3956
            10  N1y N    20.9799  -15.1254
            11  C1x C    23.7018  -17.5298
            12  C1x C    23.4296  -16.3956
            13  C1y C    24.6999  -18.0742
            14  O2a O    25.7433  -18.9362
            15  C1a C    20.2548  -13.9791
            16  C1c C    27.1433  -18.9362
            17  C8y C    27.8622  -20.1811
            18  C8y C    27.8331  -17.7424
            19  C8x C    29.2596  -17.7435
            20  C8x C    29.9605  -16.5316
            21  C8x C    29.2614  -15.3186
            22  C8x C    27.8349  -15.3175
            23  C8x C    27.1340  -16.5294
            24  C8x C    27.1708  -21.3786
            25  C8x C    27.8707  -22.5911
            26  C8x C    29.2707  -22.5912
            27  C8x C    29.9621  -21.3937
            28  C8x C    29.2622  -20.1812
BOND        30
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     1   5 2
            5     6   7 1
            6     6   8 1
            7     7   9 1
            8     8  10 1
            9     8  11 1
            10    9  12 1
            11   11  13 1
            12   13  14 1 #Down
            13    9  10 1
            14   12  13 1
            15   10  15 1
            16   14  16 1
            17   16  17 1
            18   16  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 2
            22   21  22 1
            23   22  23 2
            24   18  23 1
            25   17  24 2
            26   24  25 1
            27   25  26 2
            28   26  27 1
            29   27  28 2
            30   17  28 1

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