KEGG   DRUG: D00789Help
Entry
D00789                      Drug                                   

Name
Chlorpromazine hydrochloride (JP16/USP);
Sonazine (TN)
Product
  Generic
CHLORPROMAZINE HYDROCHLORIDE (American Health Packaging), CHLORPROMAZINE HYDROCHLORIDE (American Health Packaging), CHLORPROMAZINE HYDROCHLORIDE (Cardinal Health), CHLORPROMAZINE HYDROCHLORIDE (Clinical Solutions Wholesale), CHLORPROMAZINE HYDROCHLORIDE (Contract Pharmacy Services-PA), CHLORPROMAZINE HYDROCHLORIDE (Mylan Institutional), CHLORPROMAZINE (NCS HealthCare of KY), CHLORPROMAZINE HYDROCHLORIDE (NCS HealthCare of KY), CHLORPROMAZINE HYDROCHLORIDE (Physicians Total Care), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (REMEDYREPACK), CHLORPROMAZINE HYDROCHLORIDE (Sandoz), CHLORPROMAZINE HYDROCHLORIDE (Sandoz), CHLORPROMAZINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), CHLORPROMAZINE HYDROCHLORIDE (Upsher-Smith Laboratories), CHLORPROMAZINE HYDROCHLORIDE (West-ward Pharmaceutical Corp.)
Formula
C17H19ClN2S. HCl
Exact mass
354.0724
Mol weight
355.3251
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-emetic;
Antipsychotic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Phenothiazine derivatives
Target
5-HT2-receptor antagonist [HSA:3356 3357 3358] [KO:K04157];
H1-receptor antagonist [HSA:3269] [KO:K04149];
alpha2-adrenergic receptor antagonist [HSA:150 151 152] [KO:K04138 K04139 K04140];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145];
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antipsychotics
Phenothiazines
Antimigraines
Histamine H1 receptor antagonists
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AA Phenothiazines with aliphatic side-chain
     N05AA01 Chlorpromazine
      D00789  Chlorpromazine hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Chlorpromazine
    D00789  Chlorpromazine hydrochloride (JP16/USP)
 Antipsychotics
  1st Generation/Typical
   Chlorpromazine
    D00789  Chlorpromazine hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1171  Chlorpromazines
     D00789  Chlorpromazine hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Chlorpromazine
      D00789  Chlorpromazine hydrochloride (JP16/USP)
   Adrenaline
    alpha2-adrenergic receptor
     Chlorpromazine
      D00789  Chlorpromazine hydrochloride (JP16/USP)
   Dopamine
    dopamine D2-receptor
     Chlorpromazine
      D00789  Chlorpromazine hydrochloride (JP16/USP)
   Histamine
    H1-receptor
     Chlorpromazine
      D00789  Chlorpromazine hydrochloride (JP16/USP)
   Serotonin
    5-HT2-receptor
     Chlorpromazine
      D00789  Chlorpromazine hydrochloride (JP16/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Chlorpromazine
    D00789  Chlorpromazine hydrochloride (JP16/USP)
 Inhbitors
  CYP2D6
   Chlorpromazine
    D00789  Chlorpromazine hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00789  Chlorpromazine hydrochloride
  D00789  Chlorpromazine hydrochloride tablets
  D00789  Chlorpromazine hydrochloride injection
BRITE hierarchy
Other DBs
CAS: 
69-09-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8x C    22.8265  -17.0415
            2   C8x C    22.8265  -18.4441
            3   C8x C    24.0411  -19.1454
            4   C8y C    25.2559  -18.4441
            5   C8y C    25.2559  -17.0415
            6   C8x C    24.0411  -16.3402
            7   S2x S    26.4706  -19.1454
            8   C8y C    27.6853  -18.4441
            9   C8y C    27.6853  -17.0415
            10  N4y N    26.4706  -16.3402
            11  C8x C    28.9001  -19.1454
            12  C8x C    30.1147  -18.4441
            13  C8y C    30.1147  -17.0415
            14  C8x C    28.9001  -16.3402
            15  C1b C    26.4706  -14.9375
            16  C1b C    27.6874  -14.2350
            17  C1b C    28.8861  -14.9273
            18  N1c N    30.0752  -14.2408
            19  C1a C    31.2689  -14.9303
            20  C1a C    30.0754  -12.8338
            21  X   Cl   31.3335  -16.3379
            22  X   Cl   34.2300  -17.7100
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17   10  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   18  20 1
            23   13  21 1

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