KEGG   DRUG: D00821Help
Entry
D00821                      Drug                                   

Name
Venlafaxine hydrochloride (JAN/USAN);
Effexor (TN)
Product
  Generic
VENLAFAXINE (Aidarex Pharmaceuticals LLC), VENLAFAXINE HYDROCHLORIDE (Amneal Pharmaceuticals of New York), VENLAFAXINE (BluePoint Laboratories), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE (Heritage Pharmaceuticals), VENLAFAXINE (NCS HealthCare of KY), VENLAFAXINE (NCS HealthCare of KY), VENLAFAXINE (NorthStar RxLLC), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (Zydus Pharmaceuticals (USA)), VENLAFAXINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), VENLAFAXINE HYDROCHLORIDE (American Health Packaging), VENLAFAXINE HYDROCHLORIDE (American Health Packaging), VENLAFAXINE HYDROCHLORIDE (American Health Packaging), VENLAFAXINE HYDROCHLORIDE (Apotex Corp.), VENLAFAXINE HYDROCHLORIDE (Aurobindo Pharma Limited), VENLAFAXINE (Aurobindo Pharma Limited), VENLAFAXINE HYDROCHLORIDE (AvKARE), VENLAFAXINE HYDROCHLORIDE (AvKARE), VENLAFAXINE HYDROCHLORIDE (BTA Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Cadila Healthcare Limited), VENLAFAXINE HYDROCHLORIDE (Cadila Healthcare Limited), VENLAFAXINE HYDROCHLORIDE (Cardinal Health), VENLAFAXINE HYDROCHLORIDE (Cardinal Health), VENLAFAXINE HYDROCHLORIDE (Clinical Solutions Wholesale), VENLAFAXINE HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), VENLAFAXINE HYDROCHLORIDE (Dr.Reddy's Laboratories), VENLAFAXINE HYDROCHLORIDE (Golden State Medical Supply), VENLAFAXINE HYDROCHLORIDE (Greenstone LLC), VENLAFAXINE HYDROCHLORIDE (H.J. Harkins Company), VENLAFAXINE HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), VENLAFAXINE HYDROCHLORIDE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), VENLAFAXINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VENLAFAXINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VENLAFAXINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VENLAFAXINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VENLAFAXINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VENLAFAXINE HYDROCHLORIDE (Major Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), VENLAFAXINE HYDROCHLORIDE (MedVantx), VENLAFAXINE HYDROCHLORIDE (Mylan Institutional), VENLAFAXINE HYDROCHLORIDE (Mylan Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NCS HealthCare of KY), VENLAFAXINE HYDROCHLORIDE (Orchid Healthcare (a division of Orchid Chemicals & Pharmaceuticals Ltd.)), VENLAFAXINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Physicians Total Care), VENLAFAXINE HYDROCHLORIDE (Physicians Total Care), VENLAFAXINE HYDROCHLORIDE (Qualitest Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (Rebel Distributors Corp), VENLAFAXINE HYDROCHLORIDE (Rebel Distributors Corp.), VENLAFAXINE HYDROCHLORIDE (STAT RX USA LLC), VENLAFAXINE HYDROCHLORIDE (St. Marys Medical Park Pharmacy), VENLAFAXINE HYDROCHLORIDE (Sun Pharma Global), VENLAFAXINE HYDROCHLORIDE (Teva Pharmaceuticals USA), VENLAFAXINE HYDROCHLORIDE (Teva Pharmaceuticals USA), VENLAFAXINE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), VENLAFAXINE HYDROCHLORIDE (Unit Dose Services), VENLAFAXINE HYDROCHLORIDE (Wockhardt Limited), VENLAFAXINE HYDROCHLORIDE (Wockhardt USA LLC.), VENLAFAXINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C17H27NO2. HCl
Exact mass
313.1809
Mol weight
313.8627
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant
Remark
ATC code: 
Comment
selective serotonin norepinephrine reuptake inhibitor (SNRI)
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037];
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035]
  Pathway
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX16 Venlafaxine
      D00821  Venlafaxine hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Venlafaxine
    D00821  Venlafaxine hydrochloride (JAN/USAN)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Venlafaxine
    D00821  Venlafaxine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter) [HSA:6530] [KO:K05035]
     Venlafaxine [ATC:N06AX16]
      D00821  Venlafaxine hydrochloride (JAN/USAN)
    SLC6A4 (serotonin transporter) [HSA:6532] [KO:K05037]
     Venlafaxine [ATC:N06AX16]
      D00821  Venlafaxine hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
99300-78-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   X   Cl   27.9676  -14.4620
            2   C8x C    18.0600  -14.7700
            3   C8y C    18.0600  -16.1700
            4   C8x C    19.2724  -16.8700
            5   C8x C    20.4849  -16.1700
            6   C8y C    20.4849  -14.7700
            7   C8x C    19.2724  -14.0700
            8   C1x C    22.9097  -16.1700
            9   C1z C    22.9097  -14.7700
            10  C1c C    21.6973  -14.0700
            11  C1x C    24.1222  -16.8700
            12  C1x C    25.3346  -16.1700
            13  C1x C    25.3346  -14.7700
            14  C1x C    24.1222  -14.0700
            15  O2a O    16.8476  -16.8700
            16  C1a C    15.6521  -16.1796
            17  C1b C    21.6973  -12.6700
            18  O1a O    22.9097  -13.3700
            19  N1c N    20.4869  -11.9712
            20  C1a C    19.2924  -12.6610
            21  C1a C    20.4868  -10.5702
BOND        21
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     8   9 1
            8     9  10 1
            9     6  10 1
            10    8  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    9  14 1
            15    3  15 1
            16   15  16 1
            17   10  17 1
            18    9  18 1
            19   17  19 1
            20   19  20 1
            21   19  21 1

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