KEGG   DRUG: D00823Help
Entry
D00823                      Drug                                   

Name
Fluoxetine hydrochloride (JAN/USP);
Prozac (TN)
Product
  Generic
FLUOXETINE (Aidarex Pharmaceuticals LLC), FLUOXETINE (Aidarex Pharmaceuticals LLC), FLUOXETINE (Aurobindo Pharma Limited), FLUOXETINE (BluePoint Laboratories), FLUOXETINE (Cardinal Health), FLUOXETINE (Clinical Solutions Wholesale), FLUOXETINE (Clinical Solutions Wholesale), FLUOXETINE (Contract Pharmacy Services-PA), FLUOXETINE (Contract Pharmacy Services-PA), FLUOXETINE (DIRECT RX), FLUOXETINE (Dr.Reddy's Laboratories Limited), FLUOXETINE (Heritage Pharmaceuticals), FLUOXETINE (Lake Erie Medical DBA Quality Care Products LLC), FLUOXETINE (Lake Erie Medical DBA Quality Care Products LLC), FLUOXETINE (Legacy Pharmaceutical Packaging), FLUOXETINE (Legacy Pharmaceutical Packaging), FLUOXETINE (Life Line Home Care Services), FLUOXETINE (Major Pharmaceuticals), FLUOXETINE (McKesson Contract Packaging), FLUOXETINE (McKesson Contract Packaging), FLUOXETINE (MedVantx), FLUOXETINE (MedVantx), FLUOXETINE (MedVantx), FLUOXETINE (Medsource Pharmaceuticals), FLUOXETINE (Mylan Pharmaceuticals), FLUOXETINE (NCS HealthCare of KY), FLUOXETINE HYDROCHLORIDE (NCS HealthCare of KY), FLUOXETINE (NorthStar RxLLC), FLUOXETINE (PD-Rx Pharmaceuticals), FLUOXETINE (Pliva), FLUOXETINE (Proficient Rx LP), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (REMEDYREPACK), FLUOXETINE (Ranbaxy Pharmaceuticals), FLUOXETINE (Rebel Distributors Corp), FLUOXETINE (Rebel Distributors Corp), FLUOXETINE (STAT Rx USA LLC), FLUOXETINE (STAT Rx USA LLC), FLUOXETINE (State of Florida DOH Central Pharmacy), FLUOXETINE (Teva Pharmaceuticals USA), FLUOXETINE (Teva Pharmaceuticals USA), FLUOXETINE (Unit Dose Services), FLUOXETINE (McKesson Packaging Services Business Unit of McKesson Corporation), FLUOXETINE (Aidarex Pharmaceuticals LLC), FLUOXETINE (American Health Packaging), FLUOXETINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), FLUOXETINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), FLUOXETINE (Aurobindo Pharma Limited), FLUOXETINE HYDROCHLORIDE (AvKARE), FLUOXETINE (AvPAK), FLUOXETINE (Barr Laboratories), FLUOXETINE (Blenheim Pharmacal), FLUOXETINE (Blenheim Pharmacal), FLUOXETINE (Bryant Ranch Prepack), FLUOXETINE (Bryant Ranch Prepack), FLUOXETINE (Bryant Ranch Prepack), FLUOXETINE (Cardinal Health), FLUOXETINE HYDROCHLORIDE (Contract Pharmacy Services-PA), FLUOXETINE HYDROCHLORIDE (Dr.Reddy's Laboratories Limited), FLUOXETINE HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), FLUOXETINE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), FLUOXETINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), FLUOXETINE (Lake Erie Medical DBA Quality Care Products LLC), FLUOXETINE (Lake Erie Medical DBA Quality Care Products LLC), FLUOXETINE (Med-Health Pharma), FLUOXETINE (Morton Grove Pharmaceuticals), FLUOXETINE HYDROCHLORIDE (Mylan Pharmaceuticals), FLUOXETINE HYDROCHLORIDE (NCS HealthCare of KY), FLUOXETINE (NCS HealthCare of KY), FLUOXETINE (NCS HealthCare of KY), FLUOXETINE HYDROCHLORIDE (Northwind Pharmaceuticals), FLUOXETINE (PD-Rx Pharmaceuticals), FLUOXETINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), FLUOXETINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), FLUOXETINE (Par Pharmaceutical Companies), FLUOXETINE HYDROCHLORIDE (Par Pharmaceutical), FLUOXETINE (Pharmaceutical Associates), FLUOXETINE HYDROCHLORIDE (Physicians Total Care), FLUOXETINE HYDROCHLORIDE (Physicians Total Care), FLUOXETINE (Physicians Total Care), FLUOXETINE (Preferred Pharmaceuticals), FLUOXETINE (Preferred Pharmaceuticals), FLUOXETINE (Prodigy Health Supplier), FLUOXETINE (Proficient Rx LP), FLUOXETINE HYDROCHLORIDE (REMEDYREPACK), FLUOXETINE HYDROCHLORIDE (REMEDYREPACK), FLUOXETINE HYDROCHLORIDE (REMEDYREPACK), FLUOXETINE (ReadyMeds), FLUOXETINE HYDROCHLORIDE (Rebel Distributors Corp), FLUOXETINE (Rebel Distributors Corp), FLUOXETINE (STAT RX USA LLC), FLUOXETINE HYDROCHLORIDE (Sandoz), FLUOXETINE (Silarx Pharmaceuticals), FLUOXETINE (State of Florida DOH Central Pharmacy), FLUOXETINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), FLUOXETINE HYDROCHLORIDE (State of Florida DOH Central Pharmacy), FLUOXETINE (Teva Pharmaceuticals USA), FLUOXETINE (Teva Pharmaceuticals USA), FLUOXETINE (Unit Dose Services), FLUOXETINE (Unit Dose Services)
Formula
C17H18F3NO. HCl
Exact mass
345.1107
Mol weight
345.7871
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant
Remark
ATC code: 
Drug group: 
Comment
Selective serotonin reuptake inhibitor (SSRI)
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2C19 [HSA:1557], CYP2D6 [HSA:1565], CYP3A [HSA:1576 1577 1551]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AB Selective serotonin reuptake inhibitors
     N06AB03 Fluoxetine
      D00823  Fluoxetine hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Fluoxetine
    D00823  Fluoxetine hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (serotonin transporter)
     Fluoxetine
      D00823  Fluoxetine hydrochloride (JAN/USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Fluoxetine
    D00823  Fluoxetine hydrochloride (JAN/USP)
  CYP2D6
   Fluoxetine
    D00823  Fluoxetine hydrochloride (JAN/USP)
 Inhbitors
  CYP2C19
   Fluoxetine
    D00823  Fluoxetine hydrochloride (JAN/USP)
  CYP2D6
   Fluoxetine
    D00823  Fluoxetine hydrochloride (JAN/USP)
  CYP3A
   Fluoxetine
    D00823  Fluoxetine hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
56296-78-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C1c C    20.5485  -17.8188
            2   C8y C    20.5485  -19.2271
            3   O2a O    21.7758  -17.1117
            4   C1b C    19.3215  -17.1117
            5   C8x C    19.3155  -19.9342
            6   C8x C    21.7698  -19.9342
            7   C8y C    22.9971  -17.8188
            8   C1b C    18.1061  -17.8129
            9   C8x C    19.3155  -21.3482
            10  C8x C    21.7698  -21.3482
            11  C8x C    22.9971  -19.2271
            12  C8x C    24.2182  -17.1117
            13  N1b N    16.8788  -17.1059
            14  C8x C    20.5485  -22.0554
            15  C8x C    24.2125  -19.9342
            16  C8x C    25.4395  -17.8188
            17  C1a C    15.6575  -17.8129
            18  C8y C    25.4395  -19.2330
            19  C1d C    26.6609  -19.9400
            20  X   F    27.9757  -20.5770
            21  X   F    27.2511  -18.9409
            22  X   F    25.9713  -21.0737
            23  X   Cl   30.6600  -18.6900
BOND        23
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 1
            8     5   9 2
            9     6  10 1
            10    7  11 2
            11    7  12 1
            12    8  13 1
            13    9  14 1
            14   11  15 1
            15   12  16 2
            16   13  17 1
            17   15  18 2
            18   18  19 1
            19   19  20 1
            20   19  21 1
            21   19  22 1
            22   10  14 2
            23   16  18 1

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