| Entry |
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| Name |
Buprenorphine hydrochloride (JP16/USP);
Buprenex (TN)
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| Product |
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| Generic |
BUPRENORPHINE HCL (Cardinal Health), BUPRENORPHINE HCL (Roxane Laboratories), BUPRENORPHINE HYDROCHLORIDE (American Regent), BUPRENORPHINE HYDROCHLORIDE (Bedford Laboratories), BUPRENORPHINE HYDROCHLORIDE (Hi-Tech Pharmacal), BUPRENORPHINE HYDROCHLORIDE (Hospira), BUPRENORPHINE HYDROCHLORIDE (Midlothian Laboratories), BUPRENORPHINE HYDROCHLORIDE (REMEDYREPACK), BUPRENORPHINE HYDROCHLORIDE (REMEDYREPACK), BUPRENORPHINE HYDROCHLORIDE (Rebel Distributors Corp), BUPRENORPHINE HYDROCHLORIDE (Teva Pharmaceuticals USA), BUPRENORPHINE HYDROCHLORIDE (bryant ranch prepack) |
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| Formula |
C29H41NO4. HCl
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| Exact mass |
503.2802
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| Mol weight |
504.1011
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| Structure |
     |
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| Activity |
Analgesic
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| Remark |
Therapeutic category: ATC code: |
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| Target |
kappa-opioid receptor antagonist [HSA: 4986] [KO: K04214]; mu-opioid receptor partial agonist [HSA: 4988] [KO: K04215] |
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| Pathway |
hsa04080 Neuroactive ligand-receptor interaction | |
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| Interaction |
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| Structure map |
| Opioid analgesics | | Opioid receptor agonists/antagonists |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
114 Antipyretics and analgesics, anti-inflammatory agents
1149 Others
D00836 Buprenorphine hydrochloride (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02A OPIOIDS
N02AE Oripavine derivatives
N02AE01 Buprenorphine
D00836 Buprenorphine hydrochloride (JP16/USP)
N07 OTHER NERVOUS SYSTEM DRUGS
N07B DRUGS USED IN ADDICTIVE DISORDERS
N07BC Drugs used in opioid dependence
N07BC01 Buprenorphine
D00836 Buprenorphine hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
Anti-Addiction / Substance Abuse Treatment Agents
Opioid Antagonists
Buprenorphine
D00836 Buprenorphine hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
mu-opioid receptor [HSA:4988] [KO:K04215]
Buprenorphine [ATC:N02AE01 N07BC01]
D00836 Buprenorphine hydrochloride (JP16/USP)
kappa-opioid receptor [HSA:4986] [KO:K04214]
Buprenorphine [ATC:N02AE01 N07BC01]
D00836 Buprenorphine hydrochloride (JP16/USP)
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| Other DBs |
CAS: 53152-21-9 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 35
1 X Cl 23.5865 -20.2981
2 C1z C 16.6051 -15.0621
3 C1z C 17.7919 -15.7602
4 C1y C 15.4182 -15.7602
5 C8y C 16.6051 -13.7356
6 C1x C 17.7919 -14.3639
7 C1y C 18.9787 -15.0621
8 C1x C 17.7919 -17.1565
9 C1x C 17.2334 -16.8074
10 C1z C 15.4182 -17.0867
11 O2x O 14.7899 -14.2243
12 C8y C 15.4880 -13.0375
13 C8y C 17.8617 -13.0375
14 C1x C 20.1656 -14.3639
15 N1y N 20.1656 -15.7602
16 C1x C 18.9785 -13.7356
17 C1y C 16.6051 -17.7848
18 C1x C 16.0466 -16.1093
19 C8y C 15.4880 -11.6412
20 C8x C 17.8617 -11.6412
21 C1b C 21.3524 -15.1319
22 C8x C 16.6749 -10.9431
23 O1a O 14.3012 -10.9431
24 C1y C 22.5392 -15.8300
25 C1x C 23.2374 -17.0169
26 C1x C 23.9355 -15.8300
27 O2a O 14.0220 -17.0867
28 C1a C 13.3238 -15.8998
29 C1d C 17.3032 -18.9717
30 C1a C 18.6995 -18.9717
31 C1d C 16.6051 -20.1585
32 O1a O 18.0013 -20.1585
33 C1a C 15.2088 -20.1585
34 C1a C 17.3032 -21.3453
35 C1a C 15.7673 -21.4151
BOND 40
1 2 6 1 #Up
2 3 7 1
3 3 8 1
4 3 9 1 #Down
5 4 10 1
6 4 11 1 #Down
7 5 12 1
8 5 13 2
9 6 14 1
10 7 15 1 #Up
11 7 16 1
12 8 17 1
13 9 18 1
14 12 19 2
15 13 20 1
16 15 21 1
17 19 22 1
18 19 23 1
19 10 17 1
20 10 18 1 #Down
21 11 12 1
22 13 16 1
23 15 14 1 #Up
24 20 22 2
25 2 3 1
26 21 24 1
27 2 4 1
28 2 5 1
29 24 25 1
30 24 26 1
31 26 25 1
32 10 27 1
33 27 28 1
34 17 29 1
35 29 30 1 #Up
36 29 31 1
37 29 32 1 #Down
38 31 33 1
39 31 34 1
40 31 35 1
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