KEGG   DRUG: Buprenorphine hydrochlorideHelp
Entry
D00836                      Drug                                   

Name
Buprenorphine hydrochloride (JP17/USP);
Buprenex (TN)
Product
  Generic
BUPRENORPHINE (Sun Pharmaceutical Industries Limited), BUPRENORPHINE (Teva Pharmaceuticals USA), BUPRENORPHINE HCL (Cardinal Health), BUPRENORPHINE HCL (Lake Erie Medical DBA Quality Care Products LLC), BUPRENORPHINE HCL (Roxane Laboratories), BUPRENORPHINE HYDROCHLORIDE (A-S Medication Solutions LLC), BUPRENORPHINE (Actavis Pharma), BUPRENORPHINE HYDROCHLORIDE (American Regent), BUPRENORPHINE HYDROCHLORIDE (Hi-Tech Pharmacal), BUPRENORPHINE HYDROCHLORIDE (Hospira), BUPRENORPHINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), BUPRENORPHINE HYDROCHLORIDE (Par Pharmaceutical), BUPRENORPHINE HYDROCHLORIDE (REMEDYREPACK), BUPRENORPHINE HYDROCHLORIDE (REMEDYREPACK), BUPRENORPHINE HYDROCHLORIDE (REMEDYREPACK), BUPRENORPHINE HYDROCHLORIDE (Rebel Distributors Corp), BUPRENORPHINE HYDROCHLORIDE (TYA Pharmaceuticals), BUPRENORPHINE HYDROCHLORIDE (TYA Pharmaceuticals), BUPRENORPHINE HYDROCHLORIDE (bryant ranch prepack), BUPRENORPHINE HYDROCHLORIDE SUBLINGUAL (Mylan Pharmaceuticals), BUPRENORPHINE HYDROCHLORIDE SUBLINGUAL (REMEDYREPACK)
Formula
C29H41NO4. HCl
Exact mass
503.2802
Mol weight
504.1011
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Analgesic
 DG01586  Opioid receptor antagonist
Other
 DG01718  Drugs for addictive disorder
  DG01717  Drugs for opioid dependence
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Analgesic, Opioid receptor agonist/antagonist
Comment
Morphinan derivative, Oripavine derivative
Target
kappa-opioid receptor [HSA:4986] [KO:K04214];
mu-opioid receptor partial [HSA:4988] [KO:K04215]
  Pathway
Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Opioid analgesics
Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AE Oripavine derivatives
     N02AE01 Buprenorphine
      D00836  Buprenorphine hydrochloride (JP17/USP)
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BC Drugs used in opioid dependence
     N07BC01 Buprenorphine
      D00836  Buprenorphine hydrochloride (JP17/USP)
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Opioid Dependence Treatments
   Buprenorphine
    D00836  Buprenorphine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00836  Buprenorphine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    mu-opioid receptor
     Buprenorphine
      D00836  Buprenorphine hydrochloride (JP17/USP)
    kappa-opioid receptor
     Buprenorphine
      D00836  Buprenorphine hydrochloride (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00836  Buprenorphine hydrochloride
Anesthetics and analgesics [br08369.html]
 Analgesics
  D00836
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D00836
BRITE hierarchy
Other DBs
CAS: 
53152-21-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        35
            1   X   Cl   23.5865  -20.2981
            2   C1z C    16.6051  -15.0621
            3   C1z C    17.7919  -15.7602
            4   C1y C    15.4182  -15.7602
            5   C8y C    16.6051  -13.7356
            6   C1x C    17.7919  -14.3639
            7   C1y C    18.9787  -15.0621
            8   C1x C    17.7919  -17.1565
            9   C1x C    17.2334  -16.8074
            10  C1z C    15.4182  -17.0867
            11  O2x O    14.7899  -14.2243
            12  C8y C    15.4880  -13.0375
            13  C8y C    17.8617  -13.0375
            14  C1x C    20.1656  -14.3639
            15  N1y N    20.1656  -15.7602
            16  C1x C    18.9785  -13.7356
            17  C1y C    16.6051  -17.7848
            18  C1x C    16.0466  -16.1093
            19  C8y C    15.4880  -11.6412
            20  C8x C    17.8617  -11.6412
            21  C1b C    21.3524  -15.1319
            22  C8x C    16.6749  -10.9431
            23  O1a O    14.3012  -10.9431
            24  C1y C    22.5392  -15.8300
            25  C1x C    23.2374  -17.0169
            26  C1x C    23.9355  -15.8300
            27  O2a O    14.0220  -17.0867
            28  C1a C    13.3238  -15.8998
            29  C1d C    17.3032  -18.9717
            30  C1a C    18.6995  -18.9717
            31  C1d C    16.6051  -20.1585
            32  O1a O    18.0013  -20.1585
            33  C1a C    15.2088  -20.1585
            34  C1a C    17.3032  -21.3453
            35  C1a C    15.7673  -21.4151
BOND        40
            1     2   6 1 #Up
            2     3   7 1
            3     3   8 1
            4     3   9 1 #Down
            5     4  10 1
            6     4  11 1 #Down
            7     5  12 1
            8     5  13 2
            9     6  14 1
            10    7  15 1 #Up
            11    7  16 1
            12    8  17 1
            13    9  18 1
            14   12  19 2
            15   13  20 1
            16   15  21 1
            17   19  22 1
            18   19  23 1
            19   10  17 1
            20   10  18 1 #Down
            21   11  12 1
            22   13  16 1
            23   15  14 1 #Up
            24   20  22 2
            25    2   3 1
            26   21  24 1
            27    2   4 1
            28    2   5 1
            29   24  25 1
            30   24  26 1
            31   26  25 1
            32   10  27 1
            33   27  28 1
            34   17  29 1
            35   29  30 1 #Up
            36   29  31 1
            37   29  32 1 #Down
            38   31  33 1
            39   31  34 1
            40   31  35 1

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