KEGG   DRUG: D00849Help
Entry
D00849                      Drug                                   

Name
Methacycline hydrochloride (JAN/USP);
MTC;
Rondomycin (TN)
Formula
C22H22N2O8. HCl
Exact mass
478.1143
Mol weight
478.8796
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Same as: 
ATC code: 
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Tetracyclines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA05 Metacycline
      D00849  Methacycline hydrochloride (JAN/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor [KO:K01977]
    Tetracyclines
     Metacycline [ATC:J01AA05]
      D00849  Methacycline hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
3963-95-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   X   Cl   40.2039  -17.3526
            2   C8x C    25.2700  -17.1500
            3   C8x C    25.2700  -18.5500
            4   C8y C    26.4600  -19.2500
            5   C8y C    27.7200  -18.5500
            6   C8y C    27.7200  -17.1500
            7   C8x C    26.4600  -16.4500
            8   C5x C    28.9100  -19.2500
            9   C2y C    30.1000  -18.5500
            10  C1y C    30.1000  -17.1500
            11  C2y C    28.9100  -16.4500
            12  C2y C    31.3600  -19.2500
            13  C1z C    32.5500  -18.5500
            14  C1y C    32.5500  -17.1500
            15  C1y C    31.3600  -16.4500
            16  C5x C    33.7400  -19.2500
            17  C2y C    35.0000  -18.5500
            18  C2y C    35.0000  -17.1500
            19  C1y C    33.7400  -16.4500
            20  C2a C    28.9100  -15.0500
            21  O5x O    28.9100  -20.6500
            22  O5x O    33.7400  -20.6500
            23  O1a O    26.4600  -20.6500
            24  O1a O    31.3600  -20.6500
            25  C5a C    36.1900  -19.2500
            26  N1a N    37.3800  -18.5500
            27  O5a O    36.1900  -20.6500
            28  O1a O    36.1900  -16.4500
            29  O1a O    31.3600  -14.8400
            30  N1c N    33.7400  -14.2800
            31  O1a O    32.5500  -19.9500
            32  C1a C    34.9300  -13.5800
            33  C1a C    32.5500  -13.5800
BOND        35
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11    6  11 1
            12    9  12 2
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   10  15 1
            17   13  16 1
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   14  19 1
            22   11  20 2
            23    8  21 2
            24   16  22 2
            25    4  23 1
            26   12  24 1
            27   17  25 1
            28   25  26 1
            29   25  27 2
            30   18  28 1
            31   15  29 1 #Down
            32   19  30 1 #Down
            33   13  31 1 #Down
            34   30  32 1
            35   30  33 1

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