KEGG   DRUG: D00850Help
Entry
D00850                      Drug                                   

Name
Minocycline hydrochloride (JP16/USP);
MINO;
Arestin (TN);
Dynacin (TN);
Minocin (TN);
Solodyn (TN)
Product
  Generic
MINOCYCLINE (Par Pharmaceutical), MINOCYCLINE HYDROCHLORIDE (Actavis Pharma), MINOCYCLINE HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), MINOCYCLINE HYDROCHLORIDE (American Health Packaging), MINOCYCLINE HYDROCHLORIDE (American Health Packaging), MINOCYCLINE HYDROCHLORIDE (Aurobindo Pharma Limited), MINOCYCLINE HYDROCHLORIDE (Aurobindo Pharma Limited), MINOCYCLINE HYDROCHLORIDE (AvKARE), MINOCYCLINE HYDROCHLORIDE (AvPAK), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Caraco Pharmaceutical Laboratories), MINOCYCLINE HYDROCHLORIDE (Cardinal Health), MINOCYCLINE HYDROCHLORIDE (Cardinal Health), MINOCYCLINE HYDROCHLORIDE (Carilion Materials Management), MINOCYCLINE HYDROCHLORIDE (Clinical Solutions Wholesale), MINOCYCLINE HYDROCHLORIDE (Direct Rx), MINOCYCLINE HYDROCHLORIDE (Dispensing Solution), MINOCYCLINE HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), MINOCYCLINE HYDROCHLORIDE (Global Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Global Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), MINOCYCLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), MINOCYCLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), MINOCYCLINE HYDROCHLORIDE (Liberty Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Lupin Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Mylan Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Northwind Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), DYNACIN (Par Pharmaceutical), MINOCYCLINE HYDROCHLORIDE (Physicians Total Care), MINOCYCLINE HYDROCHLORIDE (Preferred Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Proficient Rx LP), MINOCYCLINE HYDROCHLORIDE (REMEDYREPACK), MINOCYCLINE HYDROCHLORIDE (REMEDYREPACK), MINOCYCLINE HYDROCHLORIDE (REMEDYREPACK), MINOCYCLINE HYDROCHLORIDE (Ranbaxy Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Ranbaxy Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Rebel Distributors Corp.), MINOCYCLINE HYDROCHLORIDE (Sandoz), MINOCYCLINE HYDROCHLORIDE (Teva Pharmaceuticals USA), MINOCYCLINE HYDROCHLORIDE (Unit Dose Services), MINOCYCLINE HYDROCHLORIDE (Unit Dose Services)
Formula
C23H27N3O7. HCl
Exact mass
493.1616
Mol weight
493.9373
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial [DS:H00324 H00328 H00350]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Semisynthetic tetracycline
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Tetracyclines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB23 Minocycline
      D00850  Minocycline hydrochloride (JP16/USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA08 Minocycline
      D00850  Minocycline hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Antibacterials
  Tetracyclines
   Minocycline
    D00850  Minocycline hydrochloride (JP16/USP)
 Dental and Oral Agents
  Minocycline
   D00850  Minocycline hydrochloride (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  27  Dental preparations
   276  Antibiotics
    2760  Antibiotics
     D00850  Minocycline hydrochloride (JP16/USP)
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   615  Acting mainly on gram-positive bacteria, gram-negative bacteria, rickettsia and chlamydia
    6152  Tetracycline antibiotics
     D00850  Minocycline hydrochloride (JP16/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Tetracyclines
     Minocycline
      D00850  Minocycline hydrochloride (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00850  Minocycline hydrochloride
  D00850  Minocycline hydrochloride tablets
  D00850  Minocycline hydrochloride for injection
BRITE hierarchy
Other DBs
CAS: 
13614-98-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        34
            1   C1y C    26.3399  -16.6515
            2   C1z C    26.3516  -18.0316
            3   C1y C    27.5270  -15.9498
            4   C1x C    25.1294  -15.9791
            5   C2y C    25.1703  -18.7451
            6   C5x C    27.5562  -18.7099
            7   O1a O    26.3516  -19.4294
            8   C2y C    28.7958  -16.6281
            9   N1c N    27.5094  -14.5522
            10  C1y C    23.9423  -16.6866
            11  C2y C    23.9657  -18.0667
            12  O1a O    25.1937  -20.1428
            13  C2y C    28.7433  -18.0082
            14  O5x O    27.5679  -20.1134
            15  O1a O    29.9304  -15.9206
            16  C1a C    28.7141  -13.8388
            17  C1a C    26.2931  -13.8681
            18  C1x C    22.7318  -16.0083
            19  C5x C    22.7727  -18.7861
            20  C5a C    29.9597  -18.6982
            21  C8y C    21.5389  -16.7217
            22  C8y C    21.5621  -18.1135
            23  O5x O    22.7261  -20.1836
            24  N1a N    31.1643  -17.9848
            25  O5a O    29.9772  -20.0960
            26  C8y C    20.3108  -16.0434
            27  C8y C    20.3693  -18.8387
            28  C8x C    19.1179  -16.7685
            29  N1c N    20.2874  -14.6458
            30  C8x C    19.1413  -18.1661
            31  O1a O    20.3985  -20.2422
            32  C1a C    21.4862  -13.9264
            33  C1a C    19.0652  -13.9675
            34  X   Cl   34.4400  -16.8000
BOND        36
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9     4  10 1
            10    5  11 2
            11    5  12 1
            12    6  13 1
            13    6  14 2
            14    8  15 1
            15    9  16 1
            16    9  17 1
            17   10  18 1
            18   11  19 1
            19   13  20 1
            20   18  21 1
            21   19  22 1
            22   19  23 2
            23   20  24 1
            24   20  25 2
            25   21  26 1
            26   22  27 1
            27   26  28 2
            28   26  29 1
            29   27  30 2
            30   27  31 1
            31   29  32 1
            32   29  33 1
            33    8  13 2
            34   10  11 1
            35   21  22 2
            36   28  30 1

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