KEGG   DRUG: Erythromycin estolateHelp
Entry
D00851                      Drug                                   

Name
Erythromycin estolate (USP);
Erythromycin estorate (JAN);
Ilosone (TN)
Formula
C40H71NO14. C12H26O4S
Exact mass
1055.6426
Mol weight
1056.3875
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01874  14-membered ring macrolide antibiotic
Cyp substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01933  CYP2C19 inhibitor
 DG01522  CYP3A4 inhibitor
 DG01915  CYP3A5 inhibitor
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antibacterial, Protein biosynthesis inhibitor
Comment
Macrolide
Target
50S ribosomal subunit
  Pathway
Ribosome
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A7 [HSA:1551]
Transporter: OAT2 [HSA:10864]
Interaction
CYP inhibition: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2C19 [HSA:1557]
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D00851  Erythromycin estolate (USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D00851  Erythromycin estolate (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D00851  Erythromycin estolate (USP)
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Erythromycin
    D00851  Erythromycin estolate (USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   50S subunit inhibitor
    Macrolides
     Erythromycin
      D00851  Erythromycin estolate (USP)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C19
   Erythromycin
    D00851  Erythromycin estolate (USP)
  CYP3A4
   Erythromycin
    D00851  Erythromycin estolate (USP)
  CYP3A7
   Erythromycin
    D00851  Erythromycin estolate (USP)
  CYP3A
   Erythromycin
    D00851  Erythromycin estolate (USP)
 CYP substrates
  CYP3A4
   Erythromycin
    D00851  Erythromycin estolate (USP)
  CYP3A5
   Erythromycin
    D00851  Erythromycin estolate (USP)
  CYP3A7
   Erythromycin
    D00851  Erythromycin estolate (USP)
 Transporter inhibitors
  ABCB1
   Erythromycin
    D00851  Erythromycin estolate (USP)
  SLCO1B1
   Erythromycin
    D00851  Erythromycin estolate (USP)
 Transporter substrates
  ABCC2
   Erythromycin
    D00851  Erythromycin estolate (USP)
  OAT2
   Erythromycin
    D00851  Erythromycin estolate (USP)
BRITE hierarchy
Other DBs
CAS: 
3521-62-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        72
            1   C1y C     8.6520  -15.8825
            2   C1z C     8.6520  -14.5689
            3   C1y C     7.5110  -16.5339
            4   O2a O    11.1010  -16.9101
            5   C1x C     7.5110  -13.9120
            6   O1a O     9.6429  -13.6171
            7   C1a C     9.8879  -14.9862
            8   C1y C     7.5110  -17.8476
            9   C1a C     6.5756  -15.5493
            10  C1y C    13.0541  -16.0150
            11  C1y C     7.5110  -12.5928
            12  O2a O     8.2235  -19.1557
            13  C1y C     6.3810  -18.5045
            14  C1y C    14.1798  -16.6811
            15  O2x O    13.0658  -14.7018
            16  C5x C     6.3810  -11.9414
            17  C1a C     8.6520  -11.9414
            18  C1y C     9.6844  -19.5584
            19  C7x C     5.2399  -17.8476
            20  C1a C     6.3810  -19.8180
            21  C1y C    15.3897  -16.0436
            22  O7a O    14.2385  -18.8086
            23  C1y C    14.2129  -14.0616
            24  C1y C     5.2399  -12.5928
            25  O5x O     6.3810  -10.6277
            26  C1x C     9.6844  -20.8666
            27  O2x O    10.8257  -18.9017
            28  O7x O     5.2399  -16.5339
            29  O6a O     4.2211  -18.7605
            30  C1x C    15.4060  -14.7352
            31  N1c N    16.4526  -16.7069
            32  C1a C    14.2319  -12.7505
            33  C1y C     5.2399  -13.9120
            34  C1a C     4.1044  -11.9414
            35  C1z C    10.8257  -21.5290
            36  C1y C    11.9555  -19.5584
            37  C1y C     4.1044  -15.8825
            38  C1z C     4.1044  -14.5689
            39  O1a O     6.3810  -14.5689
            40  C1y C    11.9555  -20.8666
            41  O2a O    10.8257  -22.8038
            42  C1a C    12.2172  -22.4754
            43  C1a C    13.0967  -18.9073
            44  C1b C     2.9687  -16.5339
            45  C1a C     2.9020  -15.1142
            46  O1a O     2.9020  -13.9065
            47  O1a O    13.0967  -21.5290
            48  C1a C    11.8832  -23.7278
            49  C1a C     3.0025  -17.6137
            50  C1a C    17.6537  -16.0252
            51  C7a C    15.3913  -19.4848
            52  O6a O    15.3913  -20.8340
            53  C1b C    16.5282  -18.8337
            54  C1a C    17.6754  -19.5017
            55  C1a C    16.4526  -18.0561
            56  C1b C    36.4700  -17.3600
            57  C1b C    35.2576  -18.0600
            58  C1b C    34.0621  -17.3696
            59  C1b C    32.8747  -18.0551
            60  C1b C    31.6835  -17.3671
            61  C1b C    30.4940  -18.0538
            62  C1b C    29.3039  -17.3665
            63  C1b C    28.1138  -18.0535
            64  C1b C    26.9240  -17.3663
            65  C1b C    25.7338  -18.0534
            66  C1b C    24.5440  -17.3662
            67  O2a O    23.3538  -18.0534
            68  C1a C    37.6824  -18.0600
            69  S4a S    21.9812  -18.0478
            70  O1d O    20.5800  -18.0709
            71  O1d O    21.9726  -16.6600
            72  O1d O    21.9900  -19.4600
BOND        73
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9    10   4 1 #Down
            10    5  11 1
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 1
            16   11  17 1 #Down
            17   18  12 1 #Down
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   14  22 1 #Up
            22   15  23 1
            23   16  24 1
            24   16  25 2
            25   18  26 1
            26   18  27 1
            27   19  28 1
            28   19  29 2
            29   21  30 1
            30   21  31 1 #Down
            31   23  32 1 #Down
            32   24  33 1
            33   24  34 1 #Up
            34   26  35 1
            35   27  36 1
            36   28  37 1
            37   33  38 1
            38   33  39 1 #Up
            39   35  40 1
            40   35  41 1 #Down
            41   35  42 1
            42   36  43 1 #Up
            43   37  44 1 #Down
            44   38  45 1 #Down
            45   38  46 1 #Up
            46   40  47 1 #Down
            47   41  48 1
            48   44  49 1
            49   23  30 1
            50   36  40 1
            51   37  38 1
            52   31  50 1
            53   22  51 1
            54   51  52 2
            55   51  53 1
            56   53  54 1
            57   31  55 1
            58   56  57 1
            59   57  58 1
            60   58  59 1
            61   59  60 1
            62   60  61 1
            63   61  62 1
            64   62  63 1
            65   63  64 1
            66   64  65 1
            67   65  66 1
            68   66  67 1
            69   56  68 1
            70   67  69 1
            71   69  70 1
            72   69  71 2
            73   69  72 2

» Japanese version   » Back

DBGET integrated database retrieval system