KEGG   DRUG: D00868Help
Entry
D00868                      Drug                                   

Name
Paromomycin sulfate (JAN/USP);
Humatin (TN)
Product
  Generic
Formula
C23H45N5O14. xH2SO4
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-amebic [DS:H00360]
Remark
ATC code: 
Drug group: 
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA06 Paromomycin
      D00868  Paromomycin sulfate (JAN/USP)
USP drug classification [BR:br08302]
 Antibacterials
  Aminoglycosides
   Paromomycin
    D00868  Paromomycin sulfate (JAN/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Aminoglycosides
     Paromomycin
      D00868  Paromomycin sulfate (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
1263-89-4
PubChem: 
LigandBox: 
KCF data Show

ATOM        47
            1   C1y C    15.3963  -21.6422
            2   C1y C    15.3963  -23.0324
            3   C1y C    16.5971  -23.7310
            4   C1y C    17.7980  -23.0324
            5   C1y C    17.7980  -21.6422
            6   O2x O    16.5971  -20.9505
            7   O2a O    19.0033  -20.9514
            8   C1y C    21.2124  -19.8245
            9   C1y C    21.6430  -18.5027
            10  O2x O    20.5140  -17.6796
            11  C1y C    19.3848  -18.5027
            12  C1y C    19.8223  -19.8245
            13  O2a O    23.1747  -18.0701
            14  O1a O    23.5419  -20.8494
            15  C1y C    24.7414  -20.1499
            16  C1y C    25.9503  -20.8328
            17  C1x C    27.1498  -20.1333
            18  C1y C    27.1403  -18.7438
            19  C1y C    25.9312  -18.0538
            20  C1y C    24.7318  -18.7604
            21  N1a N    25.9599  -22.2229
            22  N1a N    28.3334  -18.0369
            23  O2a O    25.9217  -16.6637
            24  C1y C    27.1218  -15.9636
            25  O2x O    28.3163  -16.6488
            26  C1y C    29.5865  -15.9489
            27  C1y C    29.5763  -14.5586
            28  C1y C    28.2972  -13.8683
            29  C1y C    27.1041  -14.5752
            30  C1b C    30.7260  -16.6322
            31  O1a O    30.7357  -18.0224
            32  N1a N    25.8923  -13.8885
            33  O1a O    28.2875  -12.4781
            34  O1a O    30.7070  -13.8516
            35  C1b C    18.0617  -18.0701
            36  O1a O    22.0243  -20.9515
            37  O1a O    17.0349  -19.0040
            38  C1b C    14.1917  -20.9498
            39  O1a O    14.1917  -23.7317
            40  N1a N    19.0033  -23.7302
            41  O1a O    16.5988  -25.1213
            42  N1a N    12.9863  -21.6410
            43  O1d O    32.8616  -22.2234
            44  S4a S    32.8546  -23.6067
            45  O1d O    34.2379  -23.6067
            46  O1d O    31.4714  -23.6067
            47  O1d O    32.8476  -24.9900
BOND        49
            1    19  23 1 #Down
            2    20  13 1 #Up
            3    10  11 1
            4    24  23 1 #Down
            5    11  12 1
            6    12   8 1
            7     5   6 1
            8     9  13 1 #Up
            9     6   1 1
            10   24  25 1
            11   25  26 1
            12   26  27 1
            13   27  28 1
            14   28  29 1
            15   29  24 1
            16   26  30 1 #Up
            17   15  14 1 #Down
            18   30  31 1
            19    5   7 1 #Down
            20   29  32 1 #Down
            21   28  33 1 #Up
            22    1   2 1
            23   27  34 1 #Down
            24    2   3 1
            25   11  35 1 #Up
            26   12   7 1 #Down
            27    3   4 1
            28    8  36 1 #Down
            29   15  16 1
            30   35  37 1
            31   16  17 1
            32    1  38 1 #Down
            33   17  18 1
            34    2  39 1 #Down
            35   18  19 1
            36    4  40 1 #Down
            37   19  20 1
            38    3  41 1 #Up
            39   20  15 1
            40   38  42 1
            41    4   5 1
            42   16  21 1 #Up
            43    8   9 1
            44   18  22 1 #Up
            45    9  10 1
            46   43  44 2
            47   44  45 1
            48   44  46 1
            49   44  47 2
BRACKET     1    30.1000  -25.9000   30.1000  -21.2800
            1    35.4900  -21.2800   35.4900  -25.9000
            1  x
 ORIGINAL  1   43  44  45  46  47
 REPEAT    1

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