KEGG   DRUG: D00873Help
Entry
D00873                      Drug                                   

Name
Lomefloxacin hydrochloride (JAN/USAN);
LFLX;
Maxaquin (TN)
Formula
C17H19F2N3O3. HCl
Exact mass
387.1161
Mol weight
387.8088
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
DNA gyrase inhibitor [KO:K02469 K02470];
topoisomerase IV inhibitor [KO:K02621 K02622]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA07 Lomefloxacin
      D00873  Lomefloxacin hydrochloride (JAN/USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE04 Lomefloxacin
      D00873  Lomefloxacin hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00873  Lomefloxacin hydrochloride (JAN/USAN)
   132  Otic and nasal agents
    1329  Others
     D00873  Lomefloxacin hydrochloride (JAN/USAN)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D00873  Lomefloxacin hydrochloride (JAN/USAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Lomefloxacin
      D00873  Lomefloxacin hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
98079-52-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   C8y C    21.5092  -15.7765
            2   C8y C    21.5092  -14.3792
            3   N4y N    22.7668  -16.4751
            4   C8y C    20.2983  -16.4751
            5   C8y C    22.7668  -13.6806
            6   C8x C    20.2983  -13.6806
            7   C8x C    23.9777  -15.7765
            8   C1b C    22.7668  -17.8724
            9   C8y C    19.0872  -15.8230
            10  X   F    20.2983  -17.8724
            11  C8y C    23.9777  -14.3792
            12  O5x O    22.7668  -12.2833
            13  C8y C    19.0872  -14.4257
            14  N1y N    17.8763  -16.5216
            15  C6a C    25.1888  -13.6806
            16  X   F    17.8763  -13.7738
            17  C1x C    17.8763  -17.9189
            18  C1x C    16.6653  -15.8696
            19  O6a O    25.1888  -12.2833
            20  O6a O    26.3997  -14.3792
            21  C1y C    16.6653  -18.6642
            22  C1x C    15.4543  -16.5682
            23  N1x N    15.4543  -17.9655
            24  C1a C    16.6653  -20.0615
            25  C1a C    21.5568  -18.5713
            26  X   Cl   28.7751  -15.9627
BOND        27
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 1
            11    5  12 2
            12    6  13 2
            13    9  14 1
            14   11  15 1
            15   13  16 1
            16   14  17 1
            17   14  18 1
            18   15  19 2
            19   15  20 1
            20   17  21 1
            21   18  22 1
            22   21  23 1
            23   21  24 1
            24    7  11 2
            25    9  13 1
            26   22  23 1
            27    8  25 1

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