KEGG   DRUG: Moxifloxacin hydrochlorideHelp
Entry
D00874                      Drug                                   

Name
Moxifloxacin hydrochloride (JAN/USAN);
MFLX;
Avelox (TN);
Vigamox (TN)
Product
  Generic
Formula
C21H24FN3O4. HCl
Exact mass
437.1518
Mol weight
437.8923
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Other
 DG01529  Topoisomerase inhibitor
  DG01528  Topoisomerase IV inhibitor
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antibacterial, Nucleic acid biosynthesis inhibitor
Comment
Fluoroquinolones
Target
DNA gyrase [KO:K02469 K02470];
topoisomerase IV [KO:K02621 K02622]
Interaction
Drug interaction
Structure map
Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA14 Moxifloxacin
      D00874  Moxifloxacin hydrochloride (JAN/USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE07 Moxifloxacin
      D00874  Moxifloxacin hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Moxifloxacin
    D00874  Moxifloxacin hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00874  Moxifloxacin hydrochloride (JAN/USAN)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D00874  Moxifloxacin hydrochloride (JAN/USAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Moxifloxacin
      D00874  Moxifloxacin hydrochloride (JAN/USAN)
Antibacterials [br08350.html]
 D00874
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D00874
BRITE hierarchy
Other DBs
CAS: 
186826-86-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   X   Cl   24.1157  -18.4050
            2   C8y C    18.9037  -16.3042
            3   N4y N    20.1198  -16.9999
            4   C8y C    17.6936  -17.0058
            5   C8y C    18.8979  -14.9068
            6   C1y C    20.1081  -18.4031
            7   C8x C    21.3241  -16.2925
            8   C8y C    16.4834  -16.3042
            9   O2a O    17.6819  -18.4031
            10  C8y C    20.1081  -14.1995
            11  C8x C    17.6936  -14.2053
            12  C1x C    20.7980  -19.6191
            13  C1x C    19.3949  -19.6016
            14  C8y C    21.3184  -14.8951
            15  N1y N    15.2966  -17.1988
            16  C8y C    16.4834  -14.9068
            17  C1a C    16.4658  -19.1047
            18  O5x O    20.0905  -12.8080
            19  C6a C    22.5227  -14.1995
            20  C1x C    14.4604  -16.0703
            21  C1x C    14.4838  -18.3388
            22  X   F    15.2672  -14.2112
            23  O6a O    23.7271  -14.9068
            24  O6a O    22.5169  -12.8023
            25  C1y C    13.1332  -16.5206
            26  C1y C    13.1449  -17.9119
            27  C1x C    11.9230  -15.8307
            28  N1x N    11.9464  -18.6135
            29  C1x C    10.7245  -16.5380
            30  C1x C    10.7362  -17.9295
BOND        33
            1     2   3 1
            2     2   4 2
            3     2   5 1
            4     3   6 1
            5     3   7 1
            6     4   8 1
            7     4   9 1
            8     5  10 1
            9     5  11 2
            10    6  12 1
            11    6  13 1
            12    7  14 2
            13    8  15 1
            14    8  16 2
            15    9  17 1
            16   10  18 2
            17   14  19 1
            18   15  20 1
            19   15  21 1
            20   16  22 1
            21   19  23 1
            22   19  24 2
            23   20  25 1
            24   21  26 1
            25   25  27 1
            26   26  28 1
            27   27  29 1
            28   28  30 1
            29   10  14 1
            30   11  16 1
            31   12  13 1
            32   25  26 1
            33   29  30 1

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