KEGG   DRUG: D00874Help
Entry
D00874                      Drug                                   

Name
Moxifloxacin hydrochloride (JAN/USAN);
MFLX;
Avelox (TN);
Vigamox (TN)
Product
  Generic
Formula
C21H24FN3O4. HCl
Exact mass
437.1518
Mol weight
437.8923
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
DNA gyrase inhibitor [KO:K02469 K02470];
topoisomerase IV inhibitor [KO:K02621] [KO:K02622]
Interaction
Drug interaction
Structure map
Quinolones
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00874  Moxifloxacin hydrochloride (JAN/USAN)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D00874  Moxifloxacin hydrochloride (JAN/USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA14 Moxifloxacin
      D00874  Moxifloxacin hydrochloride (JAN/USAN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE07 Moxifloxacin
      D00874  Moxifloxacin hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Moxifloxacin
    D00874  Moxifloxacin hydrochloride (JAN/USAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor [KO:K02469 K02470 K02621 K02622]
    Fluoroquinolones
     Moxifloxacin [ATC:J01MA14]
      D00874  Moxifloxacin hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
186826-86-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   X   Cl   24.1157  -18.4050
            2   C8y C    18.9037  -16.3042
            3   N4y N    20.1198  -16.9999
            4   C8y C    17.6936  -17.0058
            5   C8y C    18.8979  -14.9068
            6   C1y C    20.1081  -18.4031
            7   C8x C    21.3241  -16.2925
            8   C8y C    16.4834  -16.3042
            9   O2a O    17.6819  -18.4031
            10  C8y C    20.1081  -14.1995
            11  C8x C    17.6936  -14.2053
            12  C1x C    20.7980  -19.6191
            13  C1x C    19.3949  -19.6016
            14  C8y C    21.3184  -14.8951
            15  N1y N    15.2966  -17.1988
            16  C8y C    16.4834  -14.9068
            17  C1a C    16.4658  -19.1047
            18  O5x O    20.0905  -12.8080
            19  C6a C    22.5227  -14.1995
            20  C1x C    14.4604  -16.0703
            21  C1x C    14.4838  -18.3388
            22  X   F    15.2672  -14.2112
            23  O6a O    23.7271  -14.9068
            24  O6a O    22.5169  -12.8023
            25  C1y C    13.1332  -16.5206
            26  C1y C    13.1449  -17.9119
            27  C1x C    11.9230  -15.8307
            28  N1x N    11.9464  -18.6135
            29  C1x C    10.7245  -16.5380
            30  C1x C    10.7362  -17.9295
BOND        33
            1     2   3 1
            2     2   4 2
            3     2   5 1
            4     3   6 1
            5     3   7 1
            6     4   8 1
            7     4   9 1
            8     5  10 1
            9     5  11 2
            10    6  12 1
            11    6  13 1
            12    7  14 2
            13    8  15 1
            14    8  16 2
            15    9  17 1
            16   10  18 2
            17   14  19 1
            18   15  20 1
            19   15  21 1
            20   16  22 1
            21   19  23 1
            22   19  24 2
            23   20  25 1
            24   21  26 1
            25   25  27 1
            26   26  28 1
            27   27  29 1
            28   28  30 1
            29   10  14 1
            30   11  16 1
            31   12  13 1
            32   25  26 1
            33   29  30 1

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