KEGG   DRUG: D00881Help
Entry
D00881                      Drug                                   

Name
Econazole nitrate (JAN/USP);
Spectazole (TN)
Product
  Generic
Formula
C18H15Cl3N2O. HNO3
Exact mass
443.0206
Mol weight
444.6963
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antifungal [DS:H00363]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
sterol 14alpha-demethylase ihibitor [KO:K05917]
  Pathway
ko00100  Steroid biosynthesis  
 
Interaction
Drug interaction
Structure map
Antifungal agents
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   265  Antiparasitic dermatosis agents
    2655  Imidazoles
     D00881  Econazole nitrate (JAN/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
   D01A ANTIFUNGALS FOR TOPICAL USE
    D01AC Imidazole and triazole derivatives
     D01AC03 Econazole
      D00881  Econazole nitrate (JAN/USP)
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AF Imidazole derivatives
     G01AF05 Econazole
      D00881  Econazole nitrate (JAN/USP)
USP drug classification [BR:br08302]
 Antifungals
  Econazole
   D00881  Econazole nitrate (JAN/USP)
Antiinfectives [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   sterol 14alpha-demethylase inhibitor [KO:K05917]
    Imidazoles
     Econazole [ATC:D01AC03 G01AF05]
      D00881  Econazole nitrate (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
24169-02-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8y C    31.4185  -15.4000
            2   C1c C    31.4185  -13.9998
            3   C8y C    30.2051  -16.1001
            4   C8x C    32.6377  -16.1001
            5   C1b C    32.6320  -13.2940
            6   O2a O    30.2109  -13.2940
            7   C8x C    30.2051  -17.5003
            8   X   Cl   28.9799  -15.4000
            9   C8x C    32.6377  -17.5003
            10  N4y N    33.8395  -14.0057
            11  C1b C    28.9975  -13.9998
            12  C8y C    31.4185  -18.2061
            13  C8x C    34.9615  -13.1665
            14  C8x C    34.2804  -15.3203
            15  C8y C    27.7898  -13.2940
            16  X   Cl   31.4068  -19.6006
            17  C8x C    36.0888  -13.9773
            18  N5x N    35.6767  -15.3073
            19  C8x C    26.5822  -13.9998
            20  C8x C    27.7898  -11.8938
            21  C8x C    25.3628  -13.2940
            22  C8x C    26.5822  -11.1937
            23  C8y C    25.3628  -11.8938
            24  X   Cl   24.1435  -11.1937
            25  N2b N    25.4971  -18.0254 #+
            26  O1b O    24.2894  -18.7138
            27  O3a O    25.4912  -16.6252
            28  O3a O    26.7047  -18.7255 #-
BOND        29
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 1
            11    7  12 2
            12   10  13 1
            13   10  14 1
            14   11  15 1
            15   12  16 1
            16   13  17 2
            17   14  18 2
            18   15  19 1
            19   15  20 2
            20   19  21 2
            21   20  22 1
            22   21  23 1
            23   23  24 1
            24    9  12 1
            25   17  18 1
            26   22  23 2
            27   25  26 1
            28   25  27 2
            29   25  28 1

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