KEGG   DRUG: D00897Help
Entry
D00897                      Drug                                   

Name
Indinavir sulfate (USAN);
Crixivan (TN)
Product
Formula
C36H47N5O4. H2SO4
Exact mass
711.3302
Mol weight
711.868
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiviral [DS:H00406]
Remark
Same as: 
ATC code: 
Drug group: 
Target
HIV protease inhibitor [CPD:C19849]
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Interaction
CYP inhibition: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Drug interaction
Structure map
Anti-HIV agents
HIV protease inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AE Protease inhibitors
     J05AE02 Indinavir
      D00897  Indinavir sulfate (USAN)
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Protease Inhibitors
   Indinavir
    D00897  Indinavir sulfate (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Indinavir
    D00897  Indinavir sulfate (USAN)
  CYP3A5
   Indinavir
    D00897  Indinavir sulfate (USAN)
  CYP3A7
   Indinavir
    D00897  Indinavir sulfate (USAN)
 Inhbitors
  CYP3A
   Indinavir
    D00897  Indinavir sulfate (USAN)
Antivirals [br08351.html]
 D00897
Antiinfectives [br08307.html]
 Antivirals
  DG00654
BRITE hierarchy
Other DBs
CAS: 
157810-81-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        50
            1   C8y C    11.4820  -15.1198
            2   C1y C    12.5280  -14.1436
            3   C8y C    10.2268  -14.3528
            4   C8x C    11.4820  -16.5145
            5   C1y C    11.9701  -12.8883
            6   N1b N    13.6437  -14.9106
            7   C1x C    10.5754  -13.0278
            8   C8x C     9.0413  -15.1198
            9   C8x C    10.2268  -17.1421
            10  O1a O    12.6675  -11.6331
            11  C5a C    14.9687  -14.0738
            12  C8x C     9.0413  -16.4448
            13  C1c C    16.2239  -14.8409
            14  O5a O    14.9687  -12.6791
            15  C1b C    16.2239  -16.2356
            16  C1b C    17.4094  -14.0738
            17  C8y C    14.9687  -16.8632
            18  C1c C    18.5949  -14.8409
            19  C8x C    14.9684  -18.2579
            20  C8x C    13.7832  -16.1659
            21  C1b C    19.8501  -14.1436
            22  O1a O    18.5949  -16.2356
            23  C8x C    13.7832  -18.9552
            24  C8x C    12.5977  -16.8632
            25  N1y N    21.0356  -14.8409
            26  C8x C    12.5977  -18.2579
            27  C1y C    22.2210  -14.1436
            28  C1x C    21.0356  -16.2356
            29  C1x C    23.4063  -14.8409
            30  C5a C    22.2210  -12.6791
            31  C1x C    22.2210  -16.9329
            32  N1y N    23.4065  -16.2356
            33  N1b N    23.4763  -11.9818
            34  O5a O    21.0356  -11.9818
            35  C1b C    24.6617  -16.9329
            36  C1d C    24.6617  -12.6791
            37  C8y C    25.8472  -16.2356
            38  C1a C    25.9170  -13.4462
            39  C1a C    24.0341  -13.7252
            40  C1a C    25.2894  -11.4937
            41  C8x C    25.8472  -14.8409
            42  C8x C    27.0327  -16.9329
            43  C8x C    27.0327  -14.1436
            44  N5x N    28.2879  -16.2356
            45  C8x C    28.2879  -14.8409
            46  S4a S    19.5014  -19.5131
            47  O1d O    20.8961  -19.5131
            48  O1d O    18.1067  -19.5131
            49  O1d O    19.5014  -18.1184
            50  O1d O    19.5014  -20.9078
BOND        53
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Up
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1 #Up
            10    6  11 1
            11    8  12 2
            12   11  13 1
            13   11  14 2
            14   13  15 1 #Up
            15   13  16 1
            16   15  17 1
            17   16  18 1
            18   17  19 2
            19   17  20 1
            20   18  21 1
            21   18  22 1 #Up
            22   19  23 1
            23   20  24 2
            24   21  25 1
            25   23  26 2
            26   25  27 1
            27   25  28 1
            28   27  29 1
            29   27  30 1 #Down
            30   28  31 1
            31   29  32 1
            32   30  33 1
            33   30  34 2
            34   32  35 1
            35   33  36 1
            36   35  37 1
            37   36  38 1
            38   36  39 1
            39   36  40 1
            40   37  41 1
            41   37  42 2
            42   41  43 2
            43   42  44 1
            44   43  45 1
            45    5   7 1
            46    9  12 1
            47   24  26 1
            48   31  32 1
            49   44  45 2
            50   46  47 1
            51   46  48 1
            52   46  49 2
            53   46  50 2

» Japanese version   » Back

DBGET integrated database retrieval system