KEGG   DRUG: D00904Help
Entry
D00904                      Drug                                   

Name
Diclofenac sodium (JP16/USP);
Solaraze (TN);
Voltaren (TN)
Product
  Generic
DICLOFENAC SODIUM (Actavis Elizabeth LLC), DICLOFENAC SODIUM (Actavis Elizabeth LLC), DICLOFENAC (Akorn), DICLOFENAC SODIUM (American Health Packaging), DICLOFENAC SODIUM (Aphena Pharma Solutions - Tennessee), DICLOFENAC SODIUM (Aphena Pharma Solutions - Tennessee), DICLOFENAC SODIUM (AvKARE), DICLOFENAC SODIUM (Bausch & Lomb Incorporated), DICLOFENAC SODIUM (Blenheim Pharmacal), DICLOFENAC SODIUM (BluePoint Laboratories), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Cardinal Health), DICLOFENAC SODIUM (Carlsbad Technology), DICLOFENAC SODIUM (Clinical Solutions Wholesale), DICLOFENAC SODIUM (Dispensing Solutions), DICLOFENAC SODIUM (Dispensing Solutions), DICLOFENAC SODIUM (E. Fougera & Co. a division of Fougera Pharmaceuticals), DICLOFENAC SODIUM (Falcon Pharmaceuticals), DICLOFENAC SODIUM (Global Pharmaceuticals), DICLOFENAC SODIUM (H.J. Harkins Company), DICLOFENAC SODIUM (H.J. Harkins Company), DICLOFENAC SODIUM (Keltman Pharmaceuticals), DICLOFENAC SODIUM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), DICLOFENAC SODIUM (Lake Erie Medical DBA Quality Care Products LLC), DICLOFENAC SODIUM (Lake Erie Medical DBA Quality Care Products LLC), DICLOFENAC SODIUM (McKesson Packaging Services a business unit of McKesson Corporation), DICLOFENAC SODIUM (Medsource Pharmaceuticals), DICLOFENAC SODIUM (Mylan Pharmaceuticals), DICLOFENAC SODIUM (Mylan Pharmaceuticals), DICLOFENAC SODIUM (NCS HealthCare of KY), DICLOFENAC SODIUM (PACK Pharmaceuticals), DICLOFENAC SODIUM (PD-Rx Pharmaceuticals), DICLOFENAC SODIUM (PD-Rx Pharmaceuticals), DICLOFENAC SODIUM (PD-Rx Pharmaceuticals), DICLOFENAC SODIUM (PD-Rx Pharmaceuticals), DICLOFENAC SODIUM (Pack Pharmaceuticals), DICLOFENAC SODIUM (Pack Pharmaceuticals), DICLOFENAC SODIUM (Physicians Total Care), DICLOFENAC SODIUM (Physicians Total Care), DICLOFENAC SODIUM (Physicians Total Care), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM DELAYED RELEASE (REMEDYREPACK), DICLOFENAC SODIUM DELAYED RELEASE (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM DELAYED RELEASE (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (Rebel Distributors Corp), DICLOFENAC SODIUM (Rebel Distributors Corp), DICLOFENAC SODIUM (Rebel Distributors Corp), DICLOFENAC SODIUM (Rebel Distributors Corp), DICLOFENAC SODIUM EXTENDED-RELEASE (Rebel Distributors Corp.), DICLOFENAC SODIUM (STAT Rx USA LLC), DICLOFENAC SODIUM (Sandoz), DICLOFENAC SODIUM (Sandoz), DICLOFENAC SODIUM (St Marys Medical Park Pharmacy), DICLOFENAC SODIUM (Stat Rx USA), DICLOFENAC SODIUM (TEVA Pharmaceuticals USA), DICLOFENAC SODIUM (UDL Laboratories), DICLOFENAC SODIUM (Unit Dose Services), DICLOFENAC SODIUM (Unit Dose Services), DICLOFENAC SODIUM (Watson Laboratories), DICLOFENAC SODIUM (Watson Pharma)
Formula
C14H10Cl2NO2. Na
Exact mass
316.9986
Mol weight
318.1305
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-inflammatory [DS:H00445 H00630]
Remark
Therapeutic category: 
ATC code: 
Comment
nonsteroidal antiinflammatory drug (NSAIDs)
Target
cyclooxygenase-1 (COX-1) inhibitor [HSA:5742] [KO:K00509];
cyclooxygenase-2 (COX-2) inhibitor [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Transporter: ABCC2 [HSA:1244]
Interaction
Transporter inhibition: ABCC4 [HSA:10257], OAT2 [HSA:10864], OAT3 [HSA:9376]
Drug interaction
Structure map
Cyclooxygenase inhibitors
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1147  Phenylacetates
     D00904  Diclofenac sodium (JP16/USP)
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00904  Diclofenac sodium (JP16/USP)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00904  Diclofenac sodium (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX18 Diclofenac
      D00904  Diclofenac sodium (JP16/USP)
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AB Acetic acid derivatives and related substances
     M01AB05 Diclofenac
      D00904  Diclofenac sodium (JP16/USP)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA15 Diclofenac
      D00904  Diclofenac sodium (JP16/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC03 Diclofenac
      D00904  Diclofenac sodium (JP16/USP)
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Diclofenac
    D00904  Diclofenac sodium (JP16/USP)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Diclofenac
    D00904  Diclofenac sodium (JP16/USP)
 Dermatological Agents
  Diclofenac
   D00904  Diclofenac sodium (JP16/USP)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Diclofenac
    D00904  Diclofenac sodium (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   cyclooxygenase-1 (COX-1) [HSA:5742] [KO:K00509]
    Diclofenac [ATC:D11AX18 M01AB05 M02AA15 S01BC03]
     D00904  Diclofenac sodium (JP16/USP)
   cyclooxygenase-2 (COX-2) [HSA:5743] [KO:K11987]
    Diclofenac [ATC:D11AX18 M01AB05 M02AA15 S01BC03]
     D00904  Diclofenac sodium (JP16/USP)
BRITE hierarchy
Other DBs
CAS: 
15307-79-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   Z   Na   34.1141  -25.5138 #+
            2   C8x C    26.2972  -26.1573
            3   C8x C    26.2972  -27.5565
            4   C8x C    27.5089  -28.2561
            5   C8x C    28.7206  -27.5565
            6   C8y C    28.7206  -26.1573
            7   C8y C    27.5089  -25.4578
            8   C1b C    29.9510  -25.4468
            9   C6a C    31.1554  -26.1420
            10  O6a O    32.3370  -25.4597 #-
            11  O6a O    31.1558  -27.5561
            12  N1b N    27.5089  -24.0588
            13  C8y C    26.2804  -23.3494
            14  C8y C    26.2807  -21.9600
            15  C8x C    25.0692  -21.2602
            16  C8x C    23.8573  -21.9595
            17  C8x C    23.8570  -23.3489
            18  C8y C    25.0686  -24.0487
            19  X   Cl   27.5049  -21.2534
            20  X   Cl   25.0686  -25.4575
BOND        20
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     6   8 1
            8     8   9 1
            9     9  10 1
            10    9  11 2
            11    7  12 1
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   16  17 1
            17   17  18 2
            18   13  18 1
            19   14  19 1
            20   18  20 1

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