KEGG   DRUG: Diclofenac sodiumHelp
Entry
D00904                      Drug                                   

Name
Diclofenac sodium (JP17/USP);
Solaraze (TN);
Voltaren (TN)
Product
VOLTAREN (Bryant Ranch Prepack), VOLTAREN (Clinical Solutions Wholesale), VOLTAREN (Endo Pharmaceuticals), PENNSAID (Horizon Pharma), DYLOJECT (Hospira), VOLTAREN (Keltman Pharmaceuticals), VOLTAREN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), DICLOFENAC SODIUM (Lake Erie Medical DBA Quality Care Products LLC), PENNSAID (Lake Erie Medical DBA Quality Care Products LLC), PENNSAID (Mallinckrodt), VOLTAREN (Novartis Pharmaceutical Corporation), SOLARAZE (PharmaDerm a division of Fougera Pharmaceuticals), SOLARAZE (PharmaDerm a division of Fougera Pharmaceuticals), VOLTAREN (Physicians Total Care), VOLTAREN (Preferred Pharmaceuticals), VOLTAREN (Proficient Rx LP), VOLTAREN (REMEDYREPACK), VOLTAREN (Rebel Distributors Corp), PENNSAID (STAT RX USA LLC), VOLTAREN (STAT RX USA LLC), VOLTAREN (STAT Rx USA LLC), PENNSAID (Unit Dose Services), VOLTAREN (Unit Dose Services), VOLTAREN (DIRECT RX)
  Generic
DICLOFENAC SODIUM (Amneal Pharmaceuticals of New York), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (A-S Medication Solutions), DICLOFENAC SODIUM (Actavis Elizabeth LLC), DICLOFENAC SODIUM (Actavis Pharma), DICLOFENAC SODIUM (Actavis Pharma), DICLOFENAC SODIUM (Actavis Pharma), DICLOFENAC SODIUM (Actavis Pharma), DICLOFENAC (Akorn), DICLOFENAC (Altaire Pharmaceuticals), DICLOFENAC SODIUM (American Health Packaging), DICLOFENAC SODIUM (Aphena Pharma Solutions - Tennessee), DICLOFENAC SODIUM (Aphena Pharma Solutions - Tennessee), DICLOFENAC SODIUM (Apotex Corp.), DICLOFENAC SODIUM (AvKARE), DICLOFENAC SODIUM (Bausch & Lomb Incorporated), DICLOFENAC SODIUM (Blenheim Pharmacal), DICLOFENAC SODIUM (Blenheim Pharmacal), DICLOFENAC SODIUM (Blenheim Pharmacal), DICLOFENAC SODIUM (Blenheim Pharmacal), DICLOFENAC SODIUM (Blenheim Pharmacal), DICLOFENAC SODIUM (Blenheim Pharmacal), DICLOFENAC SODIUM (Blenheim Pharmacal), DICLOFENAC SODIUM (BluePoint Laboratories), DICLOFENAC SODIUM (BluePoint Laboratories), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Bryant Ranch Prepack), DICLOFENAC SODIUM (Cardinal Health), DICLOFENAC SODIUM (Carilion Materials Management), DICLOFENAC SODIUM (Carlsbad Technology), DICLOFENAC SODIUM (Clinical Solutions Wholesale), DICLOFENAC SODIUM (DIRECT RX), DICLOFENAC SODIUM (Direct RX), DICLOFENAC SODIUM (DirectRX), DICLOFENAC SODIUM (Dispensing Solutions), DICLOFENAC SODIUM (Dispensing Solutions), DICLOFENAC SODIUM (E. Fougera & Co. a division of Fougera Pharmaceuticals), DICLOFENAC SODIUM (E. Fougera & Co. a division of Fougera Pharmaceuticals), PREVIDOLRX PLUS ANALGESIC PAK (GenPak Solutions), PREVIDOLRX ANALGESIC PAK (GenPak Solutions), DICLOFENAC SODIUM (Golden State Medical Supply), DICLOFENAC SODIUM (Golden State Medical Supply), DICLOFENAC SODIUM (H.J. Harkins Company), DICLOFENAC SODIUM (H.J. Harkins Company), DICLOFENAC SODIUM (Impax Generics), DICLOFENAC SODIUM (International Brand Management), DICLOFENAC SODIUM (Keltman Pharmaceuticals), DICLOFENAC SODIUM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), DICLOFENAC (Lake Erie Medical DBA Quality Care Products LLC), DICLOFENAC SODIUM (Lake Erie Medical DBA Quality Care Products LLC), DICLOFENAC SODIUM (Lake Erie Medical DBA Quality Care Products LLC), DICLOFENAC SODIUM (Lupin Pharmaceuticals), DICLOFENAC SODIUM (McKesson Packaging Services a business unit of McKesson Corporation), DICLOFENAC SODIUM (Medsource Pharmaceuticals), DICLOFENAC SODIUM (Mylan Institutional), DICLOFENAC SODIUM (Mylan Pharmaceuticals), DICLOFENAC SODIUM (Mylan Pharmaceuticals), DICLOFENAC SODIUM (NCS HealthCare of KY), DICLOFENAC SODIUM (Northwind Pharmaceuticals), DICLOFENAC SODIUM (Novel Laboratories), DICLOFENAC SODIUM (Oceanside Pharmaceuticals), DICLOFENAC SODIUM (PACK Pharmaceuticals), DICLOFENAC SODIUM (PD-Rx Pharmaceuticals), DICLOFENAC SODIUM (PD-Rx Pharmaceuticals), DICLOFENAC SODIUM (PD-Rx Pharmaceuticals), DICLOFENAC SODIUM (PD-Rx Pharmaceuticals), DICLOFENAC SODIUM (PD-Rx Pharmaceuticals), DICLOFENAC SODIUM (PD-Rx Pharmaceuticals), DICLOFENAC SODIUM (Paddock Laboratories), DICLOFENAC SODIUM (Par Pharmaceutical), DICLOFENAC SODIUM (Pharmaceutica North America), DICLOFENAC SODIUM (Pharmaceutica North America), DICLOFENAC SODIUM (Pharmaceutica North America), DICLOFENAC SODIUM (Pharmaceutica North America), DICLOFENAC SODIUM (Physicians Total Care), DICLOFENAC SODIUM (Physicians Total Care), DICLOFENAC SODIUM (Physicians Total Care), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmaceuticals), DICLOFENAC SODIUM (Preferred Pharmcacuticals), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (Proficient Rx LP), DICLOFENAC SODIUM (PureTek Corporation), KLOFENSAID II (PureTek Corporation), XRYLIX (PureTek Corporation), DICLOFENAC SODIUM DELAYED RELEASE (REMEDYREPACK), DICLOFENAC SODIUM DELAYED RELEASE (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUMDELAYED RELEASE (REMEDYREPACK), DICLOFENAC SODIUM DELAYED RELEASE (REMEDYREPACK), DICLOFENAC SODIUM DELAYED RELEASE (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (REMEDYREPACK), DICLOFENAC SODIUM (Rebel Distributors Corp), DICLOFENAC SODIUM (Rebel Distributors Corp), DICLOFENAC SODIUM (Rebel Distributors Corp), DICLOFENAC SODIUM (Rebel Distributors Corp), DICLOFENAC SODIUM EXTENDED-RELEASE (Rebel Distributors Corp.), DICLOFENAC SODIUM (Rising Pharmaceuticals), DICLOFENAC SODIUM (Rising Pharmaceuticals), DICLOFENAC SODIUM (RxChange), DICLOFENAC SODIUM (STAT Rx USA LLC), DICLOFENAC SODIUM (Sandoz), DICLOFENAC SODIUM (Sandoz), DICLOFENAC SODIUM (Sandoz), DICLOFENAC SODIUM (Sircle Laboratories), DICLOFENAC SODIUM (Sircle Laboratories), DICLOFENAC SODIUM (Solubiomix), DICLOFENAC SODIUM (Solubiomix), DICLOFENAC SODIUM (St Marys Medical Park Pharmacy), DICLOFENAC SODIUM (St Marys Medical Park Pharmacy), DICLOFENAC SODIUM (Stat Rx USA), DICLOFENAC SODIUM (TEVA Pharmaceuticals USA), DICLOFENAC SODIUM (Taro Pharmaceuticals U.S.A.), DICLOFENAC SODIUM (Taro Pharmaceuticals U.S.A.), DICLOFENAC SODIUM (Teligent Pharma), DICLOFENAC SODIUM (Unit Dose Services), DICLOFENAC SODIUM (Unit Dose Services), DICLOFENAC SODIUM (Unit Dose Services), DICLOFENAC SODIUM D/R (Direct RX)
  Other
Formula
C14H10Cl2NO2. Na
Exact mass
316.9986
Mol weight
318.1305
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Anti-inflammatory
 DG01906  Antiinflammatory drug, acetic acid derivatives
  DG01898  Antiinflammatory drug, phenylacetic acid derivatives
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
Cyp substrate
 DG01642  CYP2C9 substrate
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor
Target
cyclooxygenase-1 (COX-1) [HSA:5742] [KO:K00509];
cyclooxygenase-2 (COX-2) [HSA:5743] [KO:K11987]
  Pathway
Arachidonic acid metabolism
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Transporter: ABCC2 [HSA:1244]
Interaction
Transporter inhibition: ABCC4 [HSA:10257], OAT2 [HSA:10864], OAT3 [HSA:9376]
Drug interaction
Structure map
Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D11 OTHER DERMATOLOGICAL PREPARATIONS
   D11A OTHER DERMATOLOGICAL PREPARATIONS
    D11AX Other dermatologicals
     D11AX18 Diclofenac
      D00904  Diclofenac sodium (JP17/USP)
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AB Acetic acid derivatives and related substances
     M01AB05 Diclofenac
      D00904  Diclofenac sodium (JP17/USP)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA15 Diclofenac
      D00904  Diclofenac sodium (JP17/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC03 Diclofenac
      D00904  Diclofenac sodium (JP17/USP)
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Diclofenac
    D00904  Diclofenac sodium (JP17/USP)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Diclofenac
    D00904  Diclofenac sodium (JP17/USP)
 Dermatological Agents
  Diclofenac
   D00904  Diclofenac sodium (JP17/USP)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Diclofenac
    D00904  Diclofenac sodium (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1147  Phenylacetates
     D00904  Diclofenac sodium (JP17/USP)
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00904  Diclofenac sodium (JP17/USP)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00904  Diclofenac sodium (JP17/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00904  Diclofenac sodium (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Diclofenac
    D00904  Diclofenac sodium (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   cyclooxygenase-1 (COX-1)
    Diclofenac
     D00904  Diclofenac sodium (JP17/USP)
   cyclooxygenase-2 (COX-2)
    Diclofenac
     D00904  Diclofenac sodium (JP17/USP)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C9
   Diclofenac
    D00904  Diclofenac sodium (JP17/USP)
 Transporter inhibitors
  ABCC4
   Diclofenac
    D00904  Diclofenac sodium (JP17/USP)
  OAT3
   Diclofenac
    D00904  Diclofenac sodium (JP17/USP)
 Transporter substrates
  ABCC2
   Diclofenac
    D00904  Diclofenac sodium (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00904  Diclofenac sodium
Antirheumatic and antigout drugs [br08366.html]
 Antirheumatic drugs
  D00904
Anesthetics and analgesics [br08369.html]
 Analgesics
  D00904
Rx-to-OTC switch list in Japan [br08314.html]
 D00904
BRITE hierarchy
Other DBs
CAS: 
15307-79-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   Z   Na   34.1141  -25.5138 #+
            2   C8x C    26.2972  -26.1573
            3   C8x C    26.2972  -27.5565
            4   C8x C    27.5089  -28.2561
            5   C8x C    28.7206  -27.5565
            6   C8y C    28.7206  -26.1573
            7   C8y C    27.5089  -25.4578
            8   C1b C    29.9510  -25.4468
            9   C6a C    31.1554  -26.1420
            10  O6a O    32.3370  -25.4597 #-
            11  O6a O    31.1558  -27.5561
            12  N1b N    27.5089  -24.0588
            13  C8y C    26.2804  -23.3494
            14  C8y C    26.2807  -21.9600
            15  C8x C    25.0692  -21.2602
            16  C8x C    23.8573  -21.9595
            17  C8x C    23.8570  -23.3489
            18  C8y C    25.0686  -24.0487
            19  X   Cl   27.5049  -21.2534
            20  X   Cl   25.0686  -25.4575
BOND        20
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     6   8 1
            8     8   9 1
            9     9  10 1
            10    9  11 2
            11    7  12 1
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   16  17 1
            17   17  18 2
            18   13  18 1
            19   14  19 1
            20   18  20 1

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