KEGG   DRUG: D00914Help
Entry
D00914                      Drug                                   

Name
Cefuroxime axetil (JP16/USP/INN);
CXM-AX;
Ceftin (TN)
Product
  Generic
CEFUROXIME AXETIL (A-S Medication Solutions LLC), CEFUROXIME AXETIL (A-S Medication Solutions LLC), CEFUROXIME AXETIL (Apotex Corp.), CEFUROXIME AXETIL (Ascend Laboratories), CEFUROXIME AXETIL (Aurobindo Pharma Limited), CEFUROXIME AXETIL (Citron Pharma LLC), CEFUROXIME AXETIL (Clinical Solutions Wholesale), CEFUROXIME AXETIL (Gen-Source Rx), CEFUROXIME AXETIL (H.J. Harkins Company), CEFUROXIME AXETIL (H.J. Harkins Company), CEFUROXIME AXETIL (Lupin Pharmaceuticals), CEFUROXIME AXETIL (MedVantx), CEFUROXIME AXETIL (NorthStar Rx LLC), CEFUROXIME AXETIL (Northstar Rx LLC), CEFUROXIME AXETIL (PD-Rx Pharmaceuticals), CEFUROXIME AXETIL (PD-Rx Pharmaceuticals), CEFUROXIME AXETIL (PD-Rx Pharmaceuticals), CEFUROXIME AXETIL (PD-Rx Pharmaceuticals), CEFUROXIME AXETIL (Physicians Total Care), CEFUROXIME AXETIL (Preferred Pharmaceuticals), CEFUROXIME AXETIL FOR ORAL SUSPENSION (Ranbaxy Pharmaceuticals), CEFUROXIME AXETIL (Rebel Distributors Corp), CEFUROXIME AXETIL (STAT Rx USA LLC), CEFUROXIME AXETIL (Wockhardt Limited), CEFUROXIME AXETIL (Wockhardt USA LLC.)
Formula
C20H22N4O10S
Exact mass
510.1057
Mol weight
510.4745
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
Semisynthetic cephalosporin: intermediate spectrum cephalosporin
prodrug, active substance: Cefuroxime [DR:D00262]
Target
penicillin binding proteins inhibitor
  Pathway
ko00550  Peptidoglycan biosynthesis  
 
Interaction
Drug interaction
Structure map
Cephalosporins - parenteral agents
Cephalosporins - oral agents
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   613  Acting mainly on gram-positive and gram-negative bacteria
    6132  Cephem antibioitics
     D00914  Cefuroxime axetil (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DC Second-generation cephalosporins
     J01DC02 Cefuroxime
      D00914  Cefuroxime axetil (JP16/USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA27 Cefuroxime
      D00914  Cefuroxime axetil (JP16/USP/INN)
USP drug classification [BR:br08302]
 Antibacterials
  Beta-lactam, Cephalosporins
   Cefuroxime
    D00914  Cefuroxime axetil (JP16/USP/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor
   Penicillin binding proteins inhibitor
    Cephems - Cephalosporins
     Cefuroxime [ATC:J01DC02]
      D00914  Cefuroxime axetil (JP16/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
64544-07-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        35
            1   C1y C    32.4830  -17.3815
            2   N1y N    32.4830  -18.7522
            3   C2y C    33.6704  -19.4375
            4   C2y C    34.8574  -18.7522
            5   C1x C    34.8574  -17.3815
            6   S2x S    33.6704  -16.6961
            7   C1y C    31.1122  -17.3815
            8   C5x C    31.1122  -18.7522
            9   N1b N    29.9252  -16.6961
            10  C5a C    28.7380  -17.3815
            11  O5a O    28.7380  -18.7522
            12  O5x O    29.9252  -19.4375
            13  C2c C    27.5508  -16.6961
            14  C1b C    36.0626  -19.4485
            15  C7a C    33.6704  -21.8391
            16  O7a O    32.4665  -22.5342
            17  O6a O    34.8407  -22.5150
            18  C8y C    26.3447  -17.3929
            19  O2x O    25.2137  -16.5965
            20  C8x C    24.1023  -17.4263
            21  C8x C    24.5479  -18.7397
            22  C8x C    25.9347  -18.7220
            23  N2b N    27.5507  -15.3044
            24  O7a O    37.2666  -18.7539
            25  C7a C    38.4302  -19.4263
            26  N1a N    39.6019  -18.7501
            27  O6a O    38.4298  -20.8040
            28  C1c C    31.2867  -21.8527
            29  O7a O    30.1305  -22.5200
            30  C7a C    28.9560  -21.8415
            31  C1a C    27.7902  -22.5142
            32  C1a C    31.2864  -20.4575
            33  O6a O    28.9562  -20.4574
            34  O2a O    28.7734  -14.5979
            35  C1a C    28.7734  -13.1979
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16    3  15 1
            17   15  16 1
            18   15  17 2
            19   13  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   18  22 2
            25   13  23 2
            26   14  24 1
            27   24  25 1
            28   25  26 1
            29   25  27 2
            30   16  28 1
            31   28  29 1
            32   29  30 1
            33   30  31 1
            34   28  32 1
            35   30  33 2
            36   23  34 1
            37   34  35 1

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