KEGG   DRUG: D00919Help
Entry
D00919                      Drug                                   

Name
Cefotaxime sodium (JP16/USP);
CTX;
Claforan (TN)
Product
  Generic
Formula
C16H16N5O7S2. Na
Exact mass
477.0389
Mol weight
477.4473
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
Semisynthetic cephalosporin: broad spectrum cephalosporin
Target
penicillin binding proteins inhibitor
  Pathway
ko00550  Peptidoglycan biosynthesis  
 
Interaction
Drug interaction
Structure map
Cephalosporins - parenteral agents
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   613  Acting mainly on gram-positive and gram-negative bacteria
    6132  Cephem antibioitics
     D00919  Cefotaxime sodium (JP16/USP)
 7  Agents not mainly for therapeutic purpose
  72  Intracorporeal diagnostic agents
   729  Miscellaneous
    7290  Miscellaneous
     D00919  Cefotaxime sodium (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DD Third-generation cephalosporins
     J01DD01 Cefotaxime
      D00919  Cefotaxime sodium (JP16/USP)
USP drug classification [BR:br08302]
 Antibacterials
  Beta-lactam, Cephalosporins
   Cefotaxime
    D00919  Cefotaxime sodium (JP16/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor
   Penicillin binding proteins inhibitor
    Cephems - Cephalosporins
     Cefotaxime [ATC:J01DD01]
      D00919  Cefotaxime sodium (JP16/USP)
BRITE hierarchy
Other DBs
CAS: 
64485-93-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        31
            1   C1y C    32.5269  -17.4019
            2   N1y N    32.5269  -18.8000
            3   C2y C    33.7155  -19.4992
            4   C2y C    34.9040  -18.8000
            5   C1x C    34.9040  -17.4019
            6   S2x S    33.7155  -16.7027
            7   C1y C    31.1288  -17.4019
            8   C5x C    31.1288  -18.8000
            9   N1b N    29.8703  -16.7027
            10  C5a C    28.6818  -17.4019
            11  O5a O    28.6818  -18.8000
            12  O5x O    29.8703  -19.4992
            13  C2c C    27.4933  -16.7027
            14  C1b C    36.1624  -19.4992
            15  C8y C    26.2349  -17.4019
            16  C8x C    25.1862  -16.5628
            17  S2x S    23.9977  -17.3319
            18  C8y C    24.4172  -18.7302
            19  N5x N    25.8154  -18.7302
            20  N2b N    27.4933  -15.3044
            21  C6a C    33.7155  -20.8974
            22  O6a O    34.9040  -21.5966 #-
            23  O6a O    32.4571  -21.5966
            24  N1a N    23.5782  -19.8487
            25  O7a O    37.3660  -18.7774
            26  C7a C    38.5855  -19.4548
            27  C1a C    39.7687  -18.7450
            28  O6a O    38.5387  -20.8548
            29  O2a O    28.6918  -14.6188
            30  C1a C    28.6918  -13.2205
            31  Z   Na   36.3022  -21.5966 #+
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16   13  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 1
            20   18  19 2
            21   15  19 1
            22   13  20 2
            23    3  21 1
            24   21  22 1
            25   21  23 2
            26   18  24 1
            27   14  25 1
            28   25  26 1
            29   26  27 1
            30   26  28 2
            31   20  29 1
            32   29  30 1

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