KEGG   DRUG: D00924Help
Entry
D00924                      Drug                                   

Name
Ceftriaxone sodium hydrate (JP16);
Ceftriaxone sodium (USP);
CTRX;
Rocephin (TN)
Product
  Generic
CEFTRIAXONE (APP Pharmaceuticals ), CEFTRIAXONE (APP Pharmaceuticals ), CEFTRIAXONE (Bedford Laboratories), CEFTRIAXONE (Cardinal Health), CEFTRIAXONE (Cardinal Health), CEFTRIAXONE (Cephazone Pharma LLC), CEFTRIAXONE (LUPIN PHARMACEUTICALS), CEFTRIAXONE (Lupin Pharmaceuticals), CEFTRIAXONE (REMEDYREPACK), CEFTRIAXONE (REMEDYREPACK), CEFTRIAXONE (REMEDYREPACK), CEFTRIAXONE (REMEDYREPACK), CEFTRIAXONE (Rebel Distributors Corp), CEFTRIAXONE (Rebel Distributors Corp), CEFTRIAXONE (Sagent Pharmaceuticals), CEFTRIAXONE (WG Critical Care), CEFTRIAXONE (WG Critical Care), CEFTRIAXONE (West-Ward Pharmaceutical Corp), CEFTRIAXONE (West-Ward Pharmaceutical Corp), CEFTRIAXONE (Wockhardt Limited), CEFTRIAXONE (Wockhardt USA LLC.), CEFTRIAXONE (AGILA SPECIALTIES PRIVATE LIMITED), CEFTRIAXONE (APP Pharmaceuticals), CEFTRIAXONE SODIUM (Apotex Corp.), CEFTRIAXONE (Apotex Corporation), CEFTRIAXONE (Apotex Corporation), CEFTRIAXONE (BAXTER HEALTHCARE CORPORATION), CEFTRIAXONE (Baxter Healthcare Corporation), CEFTRIAXONE SODIUM (Cardinal Health), CEFTRIAXONE SODIUM (Cardinal Health), CEFTRIAXONE SODIUM (Cardinal Health), CEFTRIAXONE SODIUM (Cardinal Health), CEFTRIAXONE SODIUM (Cardinal Health), CEFTRIAXONE SODIUM (Cardinal Health), CEFTRIAXONE SODIUM (Cardinal Health), ROCEPHIN (Genentech), CEFTRIAXONE SODIUM (Hospira), CEFTRIAXONE SODIUM (Hospira), CEFTRIAXONE SODIUM (Hospira), CEFTRIAXONE SODIUM (Hospira), CEFTRIAXONE SODIUM (Hospira), CEFTRIAXONE SODIUM (Physicians Total Care), CEFTRIAXONE (REMEDYREPACK), CEFTRIAXONE SODIUM (REMEDYREPACK), CEFTRIAXONE SODIUM (REMEDYREPACK), CEFTRIAXONE SODIUM (REMEDYREPACK), CEFTRIAXONE SODIUM (REMEDYREPACK), CEFTRIAXONE (REMEDYREPACK), CEFTRIAXONE SODIUM (REMEDYREPACK), CEFTRIAXONE SODIUM (REMEDYREPACK), CEFTRIAXONE SODIUM (Rebel Distributors Corp), CEFTRIAXONE (Sagent Pharmaceuticals), CEFTRIAXONE (Samson Medical Technologies), CEFTRIAXONE SODIUM (Sandoz), CEFTRIAXONE SODIUM (Sandoz), CEFTRIAXONE SODIUM (Sandoz), CEFTRIAXONE SODIUM (Sandoz)
Formula
(C18H16N8O7S3. 2Na)2. 7H2O
Exact mass
1322.0938
Mol weight
1323.1941
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Semisynthetic cephalosporin: broad spectrum cephalosporin
Target
penicillin binding proteins inhibitor
  Pathway
ko00550  Peptidoglycan biosynthesis  
 
Interaction
Drug interaction
Structure map
Cephalosporins - parenteral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DD Third-generation cephalosporins
     J01DD04 Ceftriaxone
      D00924  Ceftriaxone sodium hydrate (JP16); Ceftriaxone sodium (USP)
USP drug classification [BR:br08302]
 Antibacterials
  Beta-lactam, Cephalosporins
   Ceftriaxone
    D00924  Ceftriaxone sodium hydrate (JP16); Ceftriaxone sodium (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   613  Acting mainly on gram-positive and gram-negative bacteria
    6132  Cephem antibioitics
     D00924  Ceftriaxone sodium hydrate (JP16); Ceftriaxone sodium (USP)
 7  Agents not mainly for therapeutic purpose
  72  Intracorporeal diagnostic agents
   729  Miscellaneous
    7290  Miscellaneous
     D00924  Ceftriaxone sodium hydrate (JP16); Ceftriaxone sodium (USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor
   Penicillin binding proteins inhibitor
    Cephems - Cephalosporins
     Ceftriaxone
      D00924  Ceftriaxone sodium hydrate (JP16); Ceftriaxone sodium (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00924  Ceftriaxone sodium hydrate
BRITE hierarchy
Other DBs
CAS: 
104376-79-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        83
            1   C1y C    23.0416  -18.7698
            2   N1y N    23.0416  -20.1004
            3   C2y C    24.3021  -20.8007
            4   C2y C    25.4927  -20.1004
            5   C1x C    25.4927  -18.7698
            6   S2x S    24.3021  -18.0694
            7   C1y C    21.6409  -18.7698
            8   C5x C    21.6409  -20.1004
            9   N1b N    20.4503  -18.0694
            10  C5a C    19.2598  -18.7698
            11  O5a O    19.2598  -20.1004
            12  O5x O    20.4503  -20.8007
            13  C2c C    18.0692  -18.0694
            14  C1b C    26.6833  -20.8707
            15  C8y C    16.8086  -18.7698
            16  C8x C    15.6881  -17.9294
            17  S2x S    14.5675  -18.7698
            18  C8y C    14.9878  -20.1703
            19  N5x N    16.3885  -20.1703
            20  N2b N    18.0692  -16.5988
            21  C6a C    24.3021  -22.2014
            22  O6a O    25.4927  -22.9717 #-
            23  O6a O    23.0416  -22.9017
            24  S2a S    27.8738  -20.1703
            25  C8y C    29.0644  -20.8707
            26  N1a N    14.1474  -21.2909
            27  N5x N    29.0644  -22.2714
            28  C8y C    30.2550  -22.9717
            29  C8y C    31.5156  -22.2714
            30  N4x N    31.5156  -20.8707 #-
            31  N4y N    30.2550  -20.1703
            32  O5x O    30.2550  -24.3724
            33  O5x O    32.7062  -22.9717
            34  C1a C    30.2550  -18.7698
            35  O2a O    19.2771  -15.8881
            36  C1a C    19.2656  -14.4979
            37  Z   Na   26.9634  -22.9017 #+
            38  Z   Na   32.8461  -20.8707 #+
            39  O0  O    36.9782  -20.6606
            40  C1y C    23.0416  -18.7698
            41  N1y N    23.0416  -20.1004
            42  C2y C    24.3021  -20.8007
            43  C2y C    25.4927  -20.1004
            44  C1x C    25.4927  -18.7698
            45  S2x S    24.3021  -18.0694
            46  C1b C    26.6833  -20.8707
            47  S2a S    27.8738  -20.1703
            48  C8y C    29.0644  -20.8707
            49  N5x N    29.0644  -22.2714
            50  C8y C    30.2550  -22.9717
            51  C8y C    31.5156  -22.2714
            52  N4x N    31.5156  -20.8707 #-
            53  N4y N    30.2550  -20.1703
            54  C1a C    30.2550  -18.7698
            55  O5x O    32.7062  -22.9717
            56  O5x O    30.2550  -24.3724
            57  C6a C    24.3021  -22.2014
            58  O6a O    25.4927  -22.9717 #-
            59  O6a O    23.0416  -22.9017
            60  C5x C    21.6409  -20.1004
            61  C1y C    21.6409  -18.7698
            62  N1b N    20.4503  -18.0694
            63  C5a C    19.2598  -18.7698
            64  O5a O    19.2598  -20.1004
            65  C2c C    18.0692  -18.0694
            66  C8y C    16.8086  -18.7698
            67  C8x C    15.6881  -17.9294
            68  S2x S    14.5675  -18.7698
            69  C8y C    14.9878  -20.1703
            70  N5x N    16.3885  -20.1703
            71  N1a N    14.1474  -21.2909
            72  N2b N    18.0692  -16.5988
            73  O2a O    19.2771  -15.8881
            74  C1a C    19.2656  -14.4979
            75  O5x O    20.4503  -20.8007
            76  Z   Na   26.9634  -22.9017 #+
            77  Z   Na   32.8461  -20.8707 #+
            78  O0  O    36.9782  -20.6606
            79  O0  O    36.9782  -20.6606
            80  O0  O    36.9782  -20.6606
            81  O0  O    36.9782  -20.6606
            82  O0  O    36.9782  -20.6606
            83  O0  O    36.9782  -20.6606
BOND        78
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16   13  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 1
            20   18  19 2
            21   15  19 1
            22   13  20 2
            23    3  21 1
            24   21  22 1
            25   21  23 2
            26   14  24 1
            27   24  25 1
            28   18  26 1
            29   25  27 2
            30   27  28 1
            31   28  29 1
            32   29  30 1
            33   30  31 1
            34   25  31 1
            35   28  32 2
            36   29  33 2
            37   31  34 1
            38   20  35 1
            39   35  36 1
            40   40  41 1
            41   41  42 1
            42   42  43 2
            43   43  44 1
            44   44  45 1
            45   40  45 1
            46   40  61 1
            47   61  60 1
            48   41  60 1
            49   61  62 1 #Up
            50   62  63 1
            51   63  64 2
            52   60  75 2
            53   63  65 1
            54   43  46 1
            55   65  66 1
            56   66  67 2
            57   67  68 1
            58   68  69 1
            59   69  70 2
            60   66  70 1
            61   65  72 2
            62   42  57 1
            63   57  58 1
            64   57  59 2
            65   46  47 1
            66   47  48 1
            67   69  71 1
            68   48  49 2
            69   49  50 1
            70   50  51 1
            71   51  52 1
            72   52  53 1
            73   48  53 1
            74   50  56 2
            75   51  55 2
            76   53  54 1
            77   72  73 1
            78   73  74 1
BRACKET     1    12.5300  -24.6400   12.5300  -15.2600
            1    33.9500  -15.2600   33.9500  -24.6400
            1  2
 ORIGINAL  1    1   2   3   4   5   6  14  25  26  28  29  30  31  32  35  34
            1   33  22  23  24   8   7   9  10  11  13  15  17  18  19  20  27
            1   21  36  37  12  16  38  39
 REPEAT    1   41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56
            1   57  58  59  60  61  62  63  64  65  66  67  68  69  70  71  72
            1   73  74  75  76  77  78  79
            2    35.0000  -21.2100   35.0000  -19.8100
            2    37.3800  -19.8100   37.3800  -21.2100
            2  7
 ORIGINAL  2   40
 REPEAT    2   80  81  82  83  84  85

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