KEGG   DRUG: D00928Help
Entry
D00928                      Drug                                   

Name
Nafcillin sodium (USP);
Nafcillin sodium monohydrate;
Unipen (TN)
Product
  Generic
Formula
C21H21N2O5S. Na. H2O
Exact mass
454.1175
Mol weight
454.4719
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic, penicillin, penicillinase-resistant
Remark
ATC code: 
Comment
Semisynthetic penicillin
Target
penicillin binding proteins inhibitor
  Pathway
ko00550  Peptidoglycan biosynthesis  
 
Interaction
CYP induction: CYP1A2 [HSA:1544], CYP3A [HSA:1576 1577 1551]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01C BETA-LACTAM ANTIBACTERIALS, PENICILLINS
    J01CF Beta-lactamase resistant penicillins
     J01CF06 Nafcillin
      D00928  Nafcillin sodium (USP)
USP drug classification [BR:br08302]
 Antibacterials
  Beta-lactam, Penicillins
   Nafcillin
    D00928  Nafcillin sodium (USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor
   Penicillin binding proteins inhibitor
    Penicillins
     Nafcillin [ATC:J01CF06]
      D00928  Nafcillin sodium (USP)
BRITE hierarchy
Other DBs
CAS: 
7177-50-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        31
            1   C1y C    12.9493  -12.7967
            2   C5x C    12.9493  -14.1867
            3   N1y N    14.3393  -14.1867
            4   C1y C    14.3393  -12.7967
            5   C1y C    15.6598  -14.6036
            6   C1z C    16.4938  -13.4916
            7   S2x S    15.6598  -12.3797
            8   C1a C    17.4668  -14.4647
            9   C1a C    17.4668  -12.5187
            10  C6a C    16.1463  -15.9937
            11  O6a O    17.5362  -15.9937 #-
            12  O6a O    15.3123  -17.1057
            13  N1b N    11.7679  -12.1017
            14  C5a C    10.5863  -12.7967
            15  O5x O    11.7679  -14.8817
            16  O5a O    10.5863  -14.1867
            17  C8y C     9.3354  -12.1017
            18  C8y C     9.3354  -10.7118
            19  C8x C     8.1229  -10.0118
            20  C8x C     6.9105  -10.7118
            21  C8y C     6.9105  -12.1017
            22  C8y C     8.1229  -12.8017
            23  C8x C     5.6981  -12.8017
            24  C8x C     5.6981  -14.2017
            25  C8x C     6.9105  -14.9017
            26  C8x C     8.1229  -14.2017
            27  O2a O    10.5294  -10.0222
            28  C1b C    10.5294   -8.6222
            29  C1a C    11.7247   -7.9316
            30  Z   Na   19.1347  -16.0631 #+
            31  O0  O    22.5627  -13.7401
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     1   4 1
            5     3   5 1
            6     5   6 1
            7     6   7 1
            8     4   7 1
            9     6   8 1
            10    6   9 1
            11    5  10 1 #Down
            12   10  11 1
            13   10  12 2
            14    1  13 1 #Up
            15   13  14 1
            16    2  15 2
            17   14  16 2
            18   14  17 1
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   17  22 2
            25   21  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   22  26 1
            30   18  27 1
            31   27  28 1
            32   28  29 1

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