KEGG   DRUG: Metformin hydrochlorideHelp
Entry
D00944                      Drug                                   

Name
Metformin hydrochloride (JP17/USP);
Glucophage (TN)
Product
  Generic
METFORMIN HYDROCHLORIDE (Amneal Pharmaceuticals), METFORMIN HYDROCHLORIDE (Mylan Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HCL (aTIME CAP LABORATORIES), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions), METFORMIN HYDROCHLORIDE (A-S Medication Solutions LLC), METFORMIN HYDROCHLORIDE (Actavis Pharma), METFORMIN HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), METFORMIN HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), METFORMIN HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), METFORMIN HYDROCHLORIDE (American Health Packaging), METFORMIN HYDROCHLORIDE (American Health Packaging), METFORMIN HYDROCHLORIDE (American Health Packaging), METFORMIN HYDROCHLORIDE (American Health Packaging), METFORMIN HYDROCHLORIDE (Amneal Pharmaceuticals of New York), METFORMIN HYDROCHLORIDE (Amneal Pharmaceuticals of New York), METFORMIN HYDROCHLORIDE (Amneal Pharmaceuticals of New York), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Apotex Corp.), METFORMIN HYDROCHLORIDE (Ascend Laboratories), METFORMIN HYDROCHLORIDE (Ascend Laboratories), METFORMIN HYDROCHLORIDE (Aurobindo Pharma Limited), METFORMIN HYDROCHLORIDE (Aurobindo Pharma Limited), METFORMIN HYDROCHLORIDE (AvKARE), METFORMIN HYDROCHLORIDE (AvKARE), METFORMIN HYDROCHLORIDE (AvKARE), METFORMIN HYDROCHLORIDE (AvPAK), METFORMIN HYDROCHLORIDE (Avera McKennan Hospital), METFORMIN HYDROCHLORIDE (Avera McKennan Hospital), METFORMIN HYDROCHLORIDE (Avera McKennan Hospital), METFORMIN HYDROCHLORIDE (Blenheim Pharmacal), METFORMIN HYDROCHLORIDE (Blenheim Pharmacal), METFORMIN HYDROCHLORIDE (Blenheim Pharmacal), METFORMIN HYDROCHLORIDE (Blenheim Pharmacal), METFORMIN HYDROCHLORIDE (Blenheim Pharmacal), METFORMIN HYDROCHLORIDE (Blenheim Pharmacal), METFORMIN HYDROCHLORIDE (Blenheim Pharmacal), METFORMIN HYDROCHLORIDE (Blenheim Pharmacal), METFORMIN HYDROCHLORIDE (Blenheim Pharmacal), METFORMIN HYDROCHLORIDE (Blenheim Pharmacal), METFORMIN HYDROCHLORIDE (Blenheim Pharmacal), METFORMIN HYDROCHLORIDE (Blu Pharmaceuticals), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Cadila Healthcare Limited), METFORMIN HYDROCHLORIDE (Cadila Healthcare Limited), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Carilion Materials Management), METFORMIN HYDROCHLORIDE (Carlsbad Technology), METFORMIN HYDROCHLORIDE (Citron Pharma LLC), METFORMIN HYDROCHLORIDE (Clinical Solutions Wholesale), METFORMIN HYDROCHLORIDE (Clinical Solutions Wholesale), METFORMIN HYDROCHLORIDE (Clinical Solutions Wholesale), METFORMIN HYDROCHLORIDE (Clinical Solutions Wholesale), METFORMIN HYDROCHLORIDE (Clinical Solutions Wholesale), METFORMIN HYDROCHLORIDE (Clinical Solutions Wholesale), METFORMIN HYDROCHLORIDE (Clinical Solutions Wholesale), METFORMIN HYDROCHLORIDE (Contract Pharmacy Services-PA), METFORMIN HYDROCHLORIDE (DIRECT RX), METFORMIN HYDROCHLORIDE (Direct RX), METFORMIN HYDROCHLORIDE (Direct Rx), METFORMIN HYDROCHLORIDE (Direct Rx), METFORMIN HYDROCHLORIDE (DirectRX), METFORMIN HYDROCHLORIDE (Eon Labs), METFORMIN HYDROCHLORIDE (Eon Labs), METFORMIN HYDROCHLORIDE (Epic Pharma), METFORMIN HYDROCHLORIDE (Glenmark Pharmaceuticals), METFORMIN HYDROCHLORIDE (Golden State Medical Supply), METFORMIN HYDROCHLORIDE (Golden State Medical Supply), METFORMIN HYDROCHLORIDE (Heritage Pharmaceuticals), METFORMIN HYDROCHLORIDE (Ingenus Pharmaceuticals), METFORMIN HYDROCHLORIDE (Inventia Healthcare Private Limited), METFORMIN HYDROCHLORIDE (KAISER FOUNDATION HOSPITALS), METFORMIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METFORMIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METFORMIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METFORMIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METFORMIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METFORMIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METFORMIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METFORMIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METFORMIN HYDROCHLORIDE (Legacy Pharmaceutical Packaging), METFORMIN HYDROCHLORIDE (Liberty Pharmaceuticals), METFORMIN HYDROCHLORIDE (Life Line Home Care Services), METFORMIN HYDROCHLORIDE (Lupin Pharmaceuticals), METFORMIN HYDROCHLORIDE (Lupin Pharmaceuticals), METFORMIN HYDROCHLORIDE (MARKSANS PHARMA LIMITED), METFORMIN HYDROCHLORIDE (MARKSANS PHARMA LIMITED), METFORMIN HYDROCHLORIDE EXTENDED RELEASE (Major Pharmaceuticals), METFORMIN HYDROCHLORIDE (Major Pharmaceuticals), METFORMIN HYDROCHLORIDE (Major Pharmaceuticals), METFORMIN HYDROCHLORIDE (Major Pharmaceuticals), METFORMIN HYDROCHLORIDE (Major Pharmaceuticals), METFORMIN HYDROCHLORIDE (McKesson Contract Packaging), METFORMIN HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), METFORMIN HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), METFORMIN HYDROCHLORIDE (Med-Health Pharma), METFORMIN HYDROCHLORIDE (MedVantx), METFORMIN HYDROCHLORIDE (MedVantx), METFORMIN HYDROCHLORIDE (Mylan Institutional), METFORMIN HYDROCHLORIDE (Mylan Pharmaceuticals), METFORMIN HYDROCHLORIDE (NCS HealthCare of KY), METFORMIN HYDROCHLORIDE (NCS HealthCare of KY), METFORMIN HYDROCHLORIDE (NCS HealthCare of KY), METFORMIN HYDROCHLORIDE (NCS HealthCare of KY), METFORMIN HYDROCHLORIDE (NCS HealthCare of KY), METFORMIN HYDROCHLORIDE (New Horizon Rx Group), METFORMIN HYDROCHLORIDE (Nivagen Pharmaceuticals), METFORMIN HYDROCHLORIDE (Northwind Pharmaceuticals), METFORMIN HYDROCHLORIDE (Northwind Pharmaceuticals), METFORMIN HYDROCHLORIDE (Northwind Pharmaceuticals), METFORMIN HYDROCHLORIDE (Northwind Pharmaceuticals), METFORMIN HYDROCHLORIDE (Northwind Pharmaceuticals), METFORMIN HYDROCHLORIDE (Nostrum Laboratories), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (Physicians Total Care), METFORMIN HYDROCHLORIDE (Physicians Total Care), METFORMIN HYDROCHLORIDE (Preferred Pharmaceuticals), METFORMIN HYDROCHLORIDE (Preferred Pharmaceuticals), METFORMIN HYDROCHLORIDE (Preferred Pharmaceuticals), METFORMIN HYDROCHLORIDE (Proficient Rx LP), METFORMIN HYDROCHLORIDE (Proficient Rx LP), METFORMIN HYDROCHLORIDE (Proficient Rx LP), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (ReadyMeds), METFORMIN HYDROCHLORIDE (ReadyMeds), METFORMIN HYDROCHLORIDE (Rebel Distributors Corp), METFORMIN HYDROCHLORIDE (Rebel Distributors Corp.), METFORMIN HYDROCHLORIDE (RedPharm Drug), METFORMIN HYDROCHLORIDE (RedPharm Drug), METFORMIN HYDROCHLORIDE (RedPharm Drug), METFORMIN HYDROCHLORIDE (STAT Rx USA LLC), METFORMIN HYDROCHLORIDE (Safecor Health), METFORMIN HYDROCHLORIDE (Sandoz), METFORMIN HYDROCHLORIDE (ScieGen Pharmaceuticals), METFORMIN HYDROCHLORIDE (Solco healthcare U.S.), METFORMIN HYDROCHLORIDE (Solco healthcare U.S.), METFORMIN HYDROCHLORIDE (Solco healthcare U.S.), METFORMIN HYDROCHLORIDE (St Marys Medical Park Pharmacy), METFORMIN HYDROCHLORIDE (St Marys Medical Park Pharmacy), METFORMIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), METFORMIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), METFORMIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), METFORMIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), METFORMIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), METFORMIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), METFORMIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), METFORMIN HYDROCHLORIDE (Sun Pharmaceutical Industries Limited), METFORMIN HYDROCHLORIDE (Sun Pharmaceutical Industries), METFORMIN HYDROCHLORIDE (TAGI Pharma), METFORMIN HYDROCHLORIDE EXTENDED RELEASE (TIME CAP LABORATORIES), METFORMIN HYDROCHLORIDE (TYA Pharmaceuticals), METFORMIN HYDROCHLORIDE (TYA Pharmaceuticals), METFORMIN HYDROCHLORIDE (Teva Pharmaceuticals USA), METFORMIN HYDROCHLORIDE (Teva Pharmaceuticals USA), METFORMIN HYDROCHLORIDE (Torrent Pharmaceuticals Limited), METFORMIN HYDROCHLORIDE (Torrent Pharmaceuticals Limited), METFORMIN HYDROCHLORIDE (Unit Dose Services), METFORMIN HYDROCHLORIDE (Unit Dose Services), METFORMIN HYDROCHLORIDE (Unit Dose Services), METFORMIN HYDROCHLORIDE (Unit Dose Services), METFORMIN HYDROCHLORIDE (Unit Dose Services), METFORMIN HYDROCHLORIDE (Unit Dose Services), METFORMIN HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), METFORMIN HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), METFORMIN HYDROCHLORIDE (Golden State Medical Supply), METFORMIN HYDROCHLORIDE (Northwind Pharmaceuticals), METFORMIN HCL ER (Northwind Pharmaceuticals)
Formula
C4H11N5. HCl
Exact mass
165.0781
Mol weight
165.6246
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01684  Biguanide antidiabetic
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antidiabetic, Hypoglycemic, AMP kinase activator
  Disease
Type 2 diabetes mellitus [DS:H00409]
Comment
biguanides
Target
AMPK (PRKAA) [HSA:5562 5563] [KO:K07198]
  Pathway
Autophagy
mTOR signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Metabolism
Transporter: SLC22A2 [HSA:6582], SLC22A1 [HSA:6580], SLC47A1 [HSA:55244], SCL47A2 [HSA:146802]
Interaction
Drug interaction
Structure map
Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BA Biguanides
     A10BA02 Metformin
      D00944  Metformin hydrochloride (JP17/USP)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Metformin
    D00944  Metformin hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3962  Biguanides
     D00944  Metformin hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine protein kinases: CAMK group
   CAMKL family
    AMPK
     Metformin
      D00944  Metformin hydrochloride (JP17/USP)
Cytochrome P450 interactions [BR:br08309]
 Transporter substrates
  SLC22A2
   Metformin
    D00944  Metformin hydrochloride (JP17/USP)
  MATE1
   Metformin
    D00944  Metformin hydrochloride (JP17/USP)
  MATE2
   Metformin
    D00944  Metformin hydrochloride (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00944  Metformin hydrochloride
  D00944  Metformin hydrochloride tablets
Antidiabetics [br08361.html]
 D00944
BRITE hierarchy
Other DBs
CAS: 
1115-70-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        10
            1   C2c C    25.2991  -19.3605
            2   N1b N    24.0935  -18.6673
            3   N1c N    26.5163  -18.6673
            4   N2a N    25.2991  -20.7640
            5   C2c C    22.8764  -19.3605
            6   C1a C    27.7278  -19.3605
            7   C1a C    26.5163  -17.2579
            8   N1a N    21.6649  -18.6673
            9   N2a N    22.8764  -20.7640
            10  X   Cl   31.1135  -18.2132
BOND        8
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     5   8 1
            8     5   9 2

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