KEGG   DRUG: D00944Help
Entry
D00944                      Drug                                   
Name
Metformin hydrochloride (JP16/USP);
Glucophage (TN)
Product
  Generic
METFORMIN HYDROCHLORIDE (Amneal Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), METFORMIN HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), METFORMIN HYDROCHLORIDE (American Health Packaging), METFORMIN HYDROCHLORIDE (American Health Packaging), METFORMIN HYDROCHLORIDE (Amneal Pharmaceuticals), METFORMIN HYDROCHLORIDE (Amneal Pharmaceuticals), METFORMIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), METFORMIN HYDROCHLORIDE (Apotex Corp.), METFORMIN HYDROCHLORIDE (Ascend Laboratories), METFORMIN HYDROCHLORIDE (Ascend Laboratories), METFORMIN HYDROCHLORIDE (Aurobindo Pharma Limited), METFORMIN HYDROCHLORIDE (Aurobindo Pharma Limited), METFORMIN HYDROCHLORIDE (AvKARE), METFORMIN HYDROCHLORIDE (AvKARE), METFORMIN HYDROCHLORIDE (AvPAK), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Bryant Ranch Prepack), METFORMIN HYDROCHLORIDE (Cadila Healthcare Limited), METFORMIN HYDROCHLORIDE (Cadila Healthcare Limited), METFORMIN HYDROCHLORIDE (Caraco Pharmaceutical Laboratories), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Cardinal Health), METFORMIN HYDROCHLORIDE (Contract Pharmacy Services-PA), METFORMIN HYDROCHLORIDE (Eon Labs), METFORMIN HYDROCHLORIDE (Eon Labs), METFORMIN HYDROCHLORIDE (Glenmark Generics), METFORMIN HYDROCHLORIDE (Golden State Medical Supply), METFORMIN HYDROCHLORIDE (Greenstone LLC), METFORMIN HYDROCHLORIDE (Heritage Pharmaceuticals), METFORMIN HYDROCHLORIDE (Inventia Healthcare Private Limited), METFORMIN HYDROCHLORIDE (LUPIN PHARMACEUTICALS), METFORMIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), METFORMIN HYDROCHLORIDE (Legacy Pharmaceutical Packaging), METFORMIN HYDROCHLORIDE (Legacy Pharmaceutical Packaging), METFORMIN HYDROCHLORIDE (Life Line Home Care Services), METFORMIN HYDROCHLORIDE (MARKSANS PHARMA LIMITED), METFORMIN HYDROCHLORIDE EXTENDED RELEASE (Major Pharmaceuticals), METFORMIN HYDROCHLORIDE (Major Pharmaceuticals), METFORMIN HYDROCHLORIDE (Major Pharmaceuticals), METFORMIN HYDROCHLORIDE (Major Pharmaceuticals), METFORMIN HYDROCHLORIDE (McKesson Contract Packaging), METFORMIN HYDROCHLORIDE (Med-Health Pharma), METFORMIN HYDROCHLORIDE (MedVantx), METFORMIN HYDROCHLORIDE (MedVantx), METFORMIN HYDROCHLORIDE (Mylan Institutional), METFORMIN HYDROCHLORIDE (Mylan Pharmaceuticals), METFORMIN HYDROCHLORIDE (Mylan Pharmaceuticals), METFORMIN HYDROCHLORIDE (NCS HealthCare of KY), METFORMIN HYDROCHLORIDE (NCS HealthCare of KY), METFORMIN HYDROCHLORIDE (NCS HealthCare of KY), METFORMIN HYDROCHLORIDE (Nostrum Laboratories), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), METFORMIN HYDROCHLORIDE (Physicians Total Care), METFORMIN HYDROCHLORIDE (Physicians Total Care), METFORMIN HYDROCHLORIDE (Preferred Pharmaceuticals), METFORMIN HYDROCHLORIDE (Preferred Pharmaceuticals), METFORMIN HYDROCHLORIDE (Qualitest Pharmaceuticals), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (REMEDYREPACK), METFOMIN HYDROCHLORIDE (REMEDYREPACK), METFORMIN HYDROCHLORIDE (Rebel Distributors Corp), METFORMIN HYDROCHLORIDE (Rebel Distributors Corp.), METFORMIN HYDROCHLORIDE (STAT Rx USA LLC), METFORMIN HYDROCHLORIDE (Sandoz), METFORMIN HYDROCHLORIDE (Solco healthcare U.S.), METFORMIN HYDROCHLORIDE (Solco healthcare U.S.), METFORMIN HYDROCHLORIDE (St Marys Medical Park Pharmacy), METFORMIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), METFORMIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), METFORMIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), METFORMIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), METFORMIN HYDROCHLORIDE (Sun Pharmaceutical Industries Limited), METFORMIN HYDROCHLORIDE (Teva Pharmaceuticals USA), METFORMIN HYDROCHLORIDE (Teva Pharmaceuticals USA), METFORMIN HYDROCHLORIDE (Torrent Pharmaceuticals Limited), METFORMIN HYDROCHLORIDE (Torrent Pharmaceuticals Limited), METFORMIN HYDROCHLORIDE (UDL Laboratories), METFORMIN HYDROCHLORIDE (Unit Dose Services), METFORMIN HYDROCHLORIDE (Unit Dose Services), METFORMIN HYDROCHLORIDE (Watson Pharma), METFORMIN HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), METFORMIN HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), METFORMIN HYDROCHLORIDE EXTENDED RELEASE (REMEDYREPACK)
Formula
C4H11N5. HCl
Exact mass
165.0781
Mol weight
165.6246
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidiabetic [DS:H00409]
Remark
Therapeutic category: 
ATC code: 
Comment
biguanides
Target
AMPK activator [HSA:5562 5563] [KO:K07198]
  Pathway
hsa04140  Regulation of autophagy
hsa04150  mTOR signaling pathway
hsa04910  Insulin signaling pathway
hsa04920  Adipocytokine signaling pathway  
 
Metabolism
Transporter: SLC22A2 [HSA:6582], SLC22A1 [HSA:6580], SLC47A1 [HSA:55244], SCL47A2 [HSA:146802]
Interaction
Drug interaction
Pathway map
mTOR signaling pathway
Structure map
Antidiabetics
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3962  Biguanides
     D00944  Metformin hydrochloride (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BA Biguanides
     A10BA02 Metformin
      D00944  Metformin hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Biguanides
    Metformin
     D00944  Metformin hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine protein kinases: CAMK group
   CAMKL family
    AMPK [HSA:5562 5563] [KO:K07198]
     Metformin [ATC:A10BA02]
      D00944  Metformin hydrochloride (JP16/USP)
BRITE hierarchy
Other DBs
CAS: 
1115-70-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        10
            1   C2c C    25.2991  -19.3605
            2   N1b N    24.0935  -18.6673
            3   N1c N    26.5163  -18.6673
            4   N2a N    25.2991  -20.7640
            5   C2c C    22.8764  -19.3605
            6   C1a C    27.7278  -19.3605
            7   C1a C    26.5163  -17.2579
            8   N1a N    21.6649  -18.6673
            9   N2a N    22.8764  -20.7640
            10  X   Cl   31.1135  -18.2132
BOND        8
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     5   8 1
            8     5   9 2

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