KEGG   DRUG: D00945Help
Entry
D00945                      Drug                                   

Name
Pioglitazone hydrochloride (JP16/USP);
Actos (TN)
Product
  Generic
PIOGLITAZONE (American Health Packaging), PIOGLITAZONE (Clinical Solutions Wholesale), PIOGLITAZONE (International Labs), PIOGLITAZONE (Macleods Pharmaceuticals Limited), PIOGLITAZONE (MedVantx), PIOGLITAZONE (Mylan Institutional), PIOGLITAZONE (Mylan Pharmaceuticals), PIOGLITAZONE (Ranbaxy Pharmaceuticals), PIOGLITAZONE (Ranbaxy Pharmaceuticals), PIOGLITAZONE (Sandoz), PIOGLITAZONE (Teva Pharmaceuticals USA), PIOGLITAZONE HYDROCHLORIDE (Accord Healthcare), PIOGLITAZONE HYDROCHLORIDE (American Health Packaging), PIOGLITAZONE HYDROCHLORIDE (American Health Packaging), PIOGLITAZONE HYDROCHLORIDE (Aurobindo Pharma Limited), PIOGLITAZONE HYDROCHLORIDE (Breckenridge Pharmaceutical), PIOGLITAZONE HYDROCHLORIDE (Dispensing Solutions), PIOGLITAZONE HYDROCHLORIDE (Gen-Source Rx), PIOGLITAZONE HYDROCHLORIDE (Golden State Medical Supply), PIOGLITAZONE HYDROCHLORIDE (Watson Laboratories), PIOGLITAZONEHYDROCHLORIDE (Torrent Pharmaceuticals Limited)
Formula
C19H20N2O3S. HCl
Exact mass
392.0961
Mol weight
392.8996
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidiabetic [DS:H00409]
Remark
Therapeutic category: 
ATC code: 
Target
peroxisome proliferator-activated receptor (PPAR) gamma agonist [HSA:5468] [KO:K08530]
  Pathway
hsa03320  PPAR signaling pathway  
 
Interaction
CYP induction: CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
Antidiabetics
Peroxisome proliferator-activated receptor (PPAR) agonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D00945  Pioglitazone hydrochloride (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BG Thiazolidinediones
     A10BG03 Pioglitazone
      D00945  Pioglitazone hydrochloride (JP16/USP)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Pioglitazone
    D00945  Pioglitazone hydrochloride (JP16/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    peroxisome proliferator-activated receptor (PPAR) gamma [HSA:5468] [KO:K08530]
     Pioglitazone [ATC:A10BG03]
      D00945  Pioglitazone hydrochloride (JP16/USP)
BRITE hierarchy
Other DBs
CAS: 
112529-15-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   C1y C    36.4918  -16.3605
            2   C1b C    35.2747  -15.6584
            3   C5x C    36.5002  -17.7636
            4   S2x S    37.8328  -15.9323
            5   C8y C    34.0636  -16.3605
            6   N1x N    37.8315  -18.1968
            7   O5x O    35.3724  -18.5929
            8   C5x C    38.6556  -17.0654
            9   C8x C    32.8527  -15.6584
            10  C8x C    34.0636  -17.7589
            11  O5x O    40.0558  -17.0643
            12  C8x C    31.6415  -16.3605
            13  C8x C    32.8527  -18.4610
            14  C8y C    31.6415  -17.7589
            15  O2a O    30.4304  -18.4610
            16  C1b C    29.2134  -17.7589
            17  C1b C    28.0023  -18.4610
            18  C8y C    26.7911  -17.7589
            19  C8x C    26.7911  -16.3664
            20  N5x N    25.5800  -18.4668
            21  C8x C    25.5800  -15.6701
            22  C8x C    24.3689  -17.7647
            23  C8y C    24.3689  -16.3664
            24  C1b C    23.1580  -15.6701
            25  C1a C    21.9409  -16.3664
            26  X   Cl   42.2119  -18.3454
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 2
            9     5  10 1
            10    8  11 2
            11    9  12 1
            12   10  13 2
            13   12  14 2
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 2
            19   18  20 1
            20   19  21 1
            21   20  22 2
            22   21  23 2
            23   23  24 1
            24   24  25 1
            25    6   8 1
            26   13  14 1
            27   22  23 1

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