KEGG   DRUG: D00951Help
Entry
D00951                      Drug                                   

Name
Medroxyprogesterone acetate (JAN/USP);
Depo-provera (TN);
Depo-subq provera 104 (TN);
Provera (TN)
Product
  Generic
MEDROXYPROGESTERONE ACETATE (A-S Medication Solutions LLC), MEDROXYPROGESTERONE ACETATE (A-S Medication Solutions LLC), MEDROXYPROGESTERONE ACETATE (Aidarex Pharmaceuticals LLC), MEDROXYPROGESTERONE ACETATE (American Health Packaging), MEDROXYPROGESTERONE ACETATE (Barr Laboratories), MEDROXYPROGESTERONE ACETATE (Blenheim Pharmacal), MEDROXYPROGESTERONE ACETATE (Bryant Ranch Prepack), MEDROXYPROGESTERONE ACETATE (Bryant Ranch Prepack), MEDROXYPROGESTERONE ACETATE (Bryant Ranch Prepack), MEDROXYPROGESTERONE ACETATE (Cardinal Health), MEDROXYPROGESTERONE ACETATE (Dispensing Solutions), MEDROXYPROGESTERONE ACETATE (Greenstone LLC), MEDROXYPROGESTERONE ACETATE (Greenstone LLC), MEDROXYPROGESTERONE ACETATE (PD-Rx Pharmaceuticals), MEDROXYPROGESTERONE ACETATE (PD-Rx Pharmaceuticals), MEDROXYPROGESTERONE ACETATE (PD-Rx Pharmaceuticals), MEDROXYPROGESTERONE ACETATE (Physicians Total Care), MEDROXYPROGESTERONE ACETATE (Preferred Pharmaceuticals), MEDROXYPROGESTERONE ACETATE (Preferred Pharmaceuticals), MEDROXYPROGESTERONE ACETATE (REMEDYREPACK), MEDROXYPROGESTERONE ACETATE (REMEDYREPACK), MEDROXYPROGESTERONE ACETATE (REMEDYREPACK), MEDROXYPROGESTERONE ACETATE (REMEDYREPACK), MEDROXYPROGESTERONE ACETATE (ReadyMeds), MEDROXYPROGESTERONE ACETATE (Rebel Distributors Corp.), MEDROXYPROGESTERONE ACETATE (Teva Parenteral Medicines)
Formula
C24H34O4
Exact mass
386.2457
Mol weight
386.5244
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Progestin [DS:H00026 H00031]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
progesterone receptor agonist [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation  
 
Interaction
Drug interaction
Structure map
Antineoplastics - hormones
Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AC Progestogens
     G03AC06 Medroxyprogesterone
      D00951  Medroxyprogesterone acetate (JAN/USP)
   G03D PROGESTOGENS
    G03DA Pregnen (4) derivatives
     G03DA02 Medroxyprogesterone
      D00951  Medroxyprogesterone acetate (JAN/USP)
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L02 ENDOCRINE THERAPY
   L02A HORMONES AND RELATED AGENTS
    L02AB Progestogens
     L02AB02 Medroxyprogesterone
      D00951  Medroxyprogesterone acetate (JAN/USP)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Medroxyprogesterone
    D00951  Medroxyprogesterone acetate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   247  Estrogen and progesterone preparations
    2478  Synthetic progestins
     D00951  Medroxyprogesterone acetate (JAN/USP)
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D00951  Medroxyprogesterone acetate (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    progesterone receptor
     Medroxyprogesterone
      D00951  Medroxyprogesterone acetate (JAN/USP)
Antineoplastics [BR:br08308]
 Hormones and hormone antagonists
  Progestin
   Medroxyprogesterone
    D00951  Medroxyprogesterone acetate (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
71-58-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C1z C    28.1133  -17.0474
            2   C1z C    26.9252  -17.7172
            3   C1x C    29.2900  -17.7348
            4   O7a O    29.2900  -16.3485
            5   C5a C    28.1718  -15.6728
            6   C1y C    26.9192  -19.0861
            7   C1x C    25.7544  -17.0299
            8   C1a C    26.9778  -16.3485
            9   C1x C    29.2843  -19.0978
            10  C7a C    30.4782  -17.0299
            11  C1a C    26.9019  -14.9796
            12  O5a O    29.3543  -14.9738
            13  C1y C    25.7311  -19.7675
            14  C1x C    24.5603  -17.6998
            15  C1a C    31.6606  -16.3426
            16  O6a O    30.4724  -18.4045
            17  C1y C    24.5487  -19.0685
            18  C1x C    25.7311  -21.1364
            19  C1z C    23.3603  -19.7559
            20  C1y C    24.5370  -21.8238
            21  C2y C    23.3546  -21.1248
            22  C1x C    22.1781  -19.0628
            23  C1a C    23.3488  -18.3812
            24  C1a C    24.5953  -23.1868
            25  C2x C    22.1781  -21.8178
            26  C1x C    20.9840  -19.7559
            27  C5x C    20.9840  -21.1248
            28  O5x O    19.7957  -21.8062
BOND        31
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     4  10 1
            10    5  11 1
            11    5  12 2
            12    6  13 1
            13    7  14 1
            14   10  15 1
            15   10  16 2
            16   13  17 1
            17   13  18 1
            18   17  19 1
            19   18  20 1
            20   19  21 1
            21   19  22 1
            22   19  23 1 #Up
            23   20  24 1 #Down
            24   21  25 2
            25   22  26 1
            26   25  27 1
            27   27  28 2
            28    6   9 1
            29   14  17 1
            30   20  21 1
            31   26  27 1

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