KEGG   DRUG: D00952Help
Entry
D00952                      Drug                                   

Name
Megestrol acetate (USAN);
Megace (TN)
Product
  Generic
MEGESTROL ACETATE (Atlantic Biologicals Corps), MEGESTROL ACETATE (Barr Laboratories), MEGESTROL ACETATE (Cardinal Health), MEGESTROL ACETATE (Cardinal Health), MEGESTROL ACETATE (Cardinal Health), MEGESTROL ACETATE (Cardinal Health), MEGESTROL ACETATE (Cardinal Health), MEGESTROL ACETATE (Major Pharmaceuticals), MEGESTROL ACETATE (McKesson Packaging Services a business unit of McKesson Corporation), MEGESTROL ACETATE (McKesson Packaging Services a business unit of McKesson Corporation), MEGESTROL ACETATE (Morton Grove Pharmaceuticals), MEGESTROL ACETATE (NCS HealthCare of KY), MEGESTROL ACETATE (Par Pharmaceutical), MEGESTROL ACETATE (Par Pharmaceutical), MEGESTROL ACETATE (Pharmaceutical Associates), MEGESTROL ACETATE (Physicians Total Care), MEGESTROL ACETATE (Physicians Total Care), MEGESTROL ACETATE (Precision Dose), MEGESTROL ACETATE (Precision Dose), MEGESTROL ACETATE (Roxane Laboratories), MEGESTROL ACETATE (Roxane Laboratories), MEGESTOL (STAT RX USA LLC), MEGESTROL ACETATE (State of Florida DOH Central Pharmacy), MEGESTROL ACETATE (UDL Laboratories), MEGESTROL ACETATE (VistaPharm)
Formula
C24H32O4
Exact mass
384.2301
Mol weight
384.5085
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Indication: For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS).
Target
progesterone receptor agonist [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation  
 
Interaction
Drug interaction
Structure map
Antineoplastics - hormones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AC Progestogens
     G03AC05 Megestrol
      D00952  Megestrol acetate (USAN)
   G03D PROGESTOGENS
    G03DB Pregnadien derivatives
     G03DB02 Megestrol
      D00952  Megestrol acetate (USAN)
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L02 ENDOCRINE THERAPY
   L02A HORMONES AND RELATED AGENTS
    L02AB Progestogens
     L02AB01 Megestrol
      D00952  Megestrol acetate (USAN)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Megestrol
    D00952  Megestrol acetate (USAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    progesterone receptor
     Megestrol
      D00952  Megestrol acetate (USAN)
Antineoplastics [BR:br08308]
 Hormones and hormone antagonists
  Progestin
   Megestrol
    D00952  Megestrol acetate (USAN)
BRITE hierarchy
Other DBs
CAS: 
595-33-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C1z C    28.1137  -17.0472
            2   C1z C    26.9253  -17.7170
            3   C1x C    29.2906  -17.7287
            4   O7a O    29.2906  -16.3538
            5   C5a C    28.1722  -15.6723
            6   C1y C    26.9837  -19.0862
            7   C1x C    25.7544  -17.0296
            8   C1a C    26.9079  -16.3481
            9   C1x C    29.2789  -19.0978
            10  C7a C    30.4789  -17.0355
            11  C1a C    26.9020  -14.9789
            12  O5a O    29.2848  -14.9732
            13  C1y C    25.7311  -19.7677
            14  C1x C    24.5601  -17.6996
            15  C1a C    31.6616  -16.3481
            16  O6a O    30.4732  -18.4104
            17  C1y C    24.5484  -19.0686
            18  C2x C    25.7311  -21.1368
            19  C1z C    23.3599  -19.7503
            20  C2y C    24.5368  -21.8184
            21  C2y C    23.3542  -21.1252
            22  C1x C    22.1774  -19.0629
            23  C1a C    23.3484  -18.3812
            24  C1a C    24.5951  -23.1875
            25  C2x C    22.1774  -21.8184
            26  C1x C    20.9832  -19.7503
            27  C5x C    20.9832  -21.1252
            28  O5x O    19.7946  -21.8067
BOND        31
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     4  10 1
            10    5  11 1
            11    5  12 2
            12    6  13 1
            13    7  14 1
            14   10  15 1
            15   10  16 2
            16   13  17 1
            17   13  18 1
            18   17  19 1
            19   18  20 2
            20   19  21 1
            21   19  22 1
            22   19  23 1 #Up
            23   20  24 1
            24   21  25 2
            25   22  26 1
            26   25  27 1
            27   27  28 2
            28    6   9 1
            29   14  17 1
            30   20  21 1
            31   26  27 1

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