KEGG   DRUG: AnastrozoleHelp
Entry
D00960                      Drug                                   

Name
Anastrozole (JAN/USAN/INN);
Arimidex (TN)
Product
  Generic
ANASTROZOLE (Accord Healthcare), ANASTROZOLE (American Health Packaging), ANASTROZOLE (Apotex Corp.), ANASTROZOLE (Ascend Laboratories), ANASTROZOLE (Ascend Laboratories), ANASTROZOLE (Avera McKennan Hospital), ANASTROZOLE (BluePoint Laboratories), ANASTROZOLE (Breckenridge Pharmaceutical), ANASTROZOLE (Bryant Ranch Prepack), ANASTROZOLE (Bryant Ranch Prepack), ANASTROZOLE (Cadila Healthcare Limited), ANASTROZOLE (Dispensing Solutions), ANASTROZOLE (Dr. Reddy's Laboratories Limited), ANASTROZOLE (Golden State Medical Supply), ANASTROZOLE (KAISER FOUNDATION HOSPITALS), ANASTROZOLE (Kremers Urban Pharmaceuticals), ANASTROZOLE (Major Pharmaceuticals), ANASTROZOLE (Northwind Pharmaceuticals), ANASTROZOLE (NuCare Pharmaceuticals), ANASTROZOLE (PD-Rx Pharmaceuticals), ANASTROZOLE (Physicians Total Care), ANASTROZOLE (Preferred Pharmaceuticals), ANASTROZOLE (Proficient Rx LP), ANASTROZOLE (Rebel Distributors Corp), ANASTROZOLE (Rebel Distributors Corp), ANASTROZOLE (Rising Pharmaceuticals), ANASTROZOLE (STASON PHARMACEUTICALS), ANASTROZOLE (Sandoz), ANASTROZOLE (Synthon Pharmaceuticals), ANASTROZOLE (Teva Pharmaceuticals USA), ANASTROZOLE (Zydus Pharmaceuticals (USA))
Formula
C17H19N5
Exact mass
293.164
Mol weight
293.3663
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Antineoplastic
 DG01596  Aromatase inhibitor
 DG01524  Triazole antineoplastic
Cyp inhibitor
 DG01634  CYP1A2 inhibitor
 DG01643  CYP2C9 inhibitor
 DG01522  CYP3A4 inhibitor
Remark
Same as: C08159
Therapeutic category: 4291
ATC code: L02BG03
Product: D00960<JP/US>
Efficacy
Antineoplastic, Estrogen biosynthesis inhibitor
  Disease
Breast cancer, postmenopausal [DS:H00031]
Comment
Aromatase inhibitor
Target
CYP19A1 (ARO) [HSA:1588] [KO:K07434]
  Pathway
hsa00140  Steroid hormone biosynthesis
Interaction
CYP inhibition: CYP1A2 [HSA:1544], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Drug interaction
Structure map
map07043  Antineoplastics - hormones
Other map
map01522  Endocrine resistance
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L02 ENDOCRINE THERAPY
   L02B HORMONE ANTAGONISTS AND RELATED AGENTS
    L02BG Aromatase inhibitors
     L02BG03 Anastrozole
      D00960  Anastrozole (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Aromatase Inhibitors, 3rd Generation
   Anastrozole
    D00960  Anastrozole (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D00960  Anastrozole (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Cytochrome P450
    CYP19A1 (ARO)
     D00960  Anastrozole (JAN/USAN/INN) <JP/US>
Antineoplastics [br08340.html]
 D00960
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00960
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Companion diagnostics
  D00960
BRITE hierarchy
Other DBs
CAS: 120511-73-1
PubChem: 7848023
ChEBI: 2704
ChEMBL: CHEMBL1399
DrugBank: DB01217
LigandBox: D00960
NIKKAJI: J592.428F
KCF data Show

ATOM        22
            1   C8x C     8.8900  -10.7800
            2   C8y C     8.8900  -12.1800
            3   C8x C    10.1024  -12.8800
            4   C8y C    11.3149  -12.1800
            5   C8x C    11.3149  -10.7800
            6   C8y C    10.1024  -10.0800
            7   C1b C    10.1024   -8.6802
            8   N4y N    11.2980   -7.9898
            9   C1d C     7.6776  -12.8800
            10  C1d C    12.5460  -12.8910
            11  C3b C    13.7584  -13.5910
            12  C1a C    11.8467  -14.1019
            13  C1a C    13.2468  -11.6774
            14  N3a N    14.9709  -14.2910
            15  C3b C     6.4651  -13.5800
            16  C1a C     6.9834  -11.6773
            17  C1a C     8.3830  -14.1021
            18  N3a N     5.2527  -14.2800
            19  N5x N    12.6279   -8.4272
            20  C8x C    13.4536   -7.2966
            21  N5x N    12.6335   -6.1620
            22  C8x C    11.3009   -6.5913
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     2   9 1
            10    4  10 1
            11   10  11 1
            12   10  12 1
            13   10  13 1
            14   11  14 3
            15    9  15 1
            16    9  16 1
            17    9  17 1
            18   15  18 3
            19    8  19 1
            20   19  20 2
            21   20  21 1
            22   21  22 2
            23    8  22 1

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