KEGG   DRUG: D00960Help
Entry
D00960                      Drug                                   

Name
Anastrozole (JAN/USAN/INN);
Arimidex (TN)
Product
  Generic
ANASTROZOLE (APP Pharmaceuticals), ANASTROZOLE (Accord Healthcare), ANASTROZOLE (American Health Packaging), ANASTROZOLE (Apotex Corp.), ANASTROZOLE (Ascend Laboratories), ANASTROZOLE (Ascend Laboratories), ANASTROZOLE (BluePoint Laboratories), ANASTROZOLE (Breckenridge Pharmaceutical), ANASTROZOLE (Bryant Ranch Prepack), ANASTROZOLE (Cadila Healthcare Limited), ANASTROZOLE (Cypress Pharmaceutical), ANASTROZOLE (Dispensing Solutions), ANASTROZOLE (Dr. Reddy's Laboratories Limited), ANASTROZOLE (Golden State Medical Supply), ANASTROZOLE (KAISER FOUNDATION HOSPITALS), ANASTROZOLE (Kadmon Pharmaceuticals), ANASTROZOLE (Kremers Urban Pharmaceuticals), ANASTROZOLE (Major Pharmaceuticals), ANASTROZOLE (Major Pharmaceuticals), ANASTROZOLE (Mylan Pharmaceuticals), ANASTROZOLE (PD-Rx Pharmaceuticals), ANASTROZOLE (Pack Pharmaceuticals), ANASTROZOLE (Physicians Total Care), ANASTROZOLE (Proficient Rx LP), ANASTROZOLE (Rebel Distributors Corp), ANASTROZOLE (Rebel Distributors Corp), ANASTROZOLE (Roxane Laboratories), ANASTROZOLE (Sandoz), ANASTROZOLE (Sun Pharmaceutical Industries Limited), ANASTROZOLE (Synthon Pharmaceuticals), ANASTROZOLE (Teva Pharmaceuticals USA), ANASTROZOLE (UDL Laboratories), ANASTROZOLE (Zydus Pharmaceuticals (USA))
Formula
C17H19N5
Exact mass
293.164
Mol weight
293.3663
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic [DS:H00031]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
aromatase inhibitor [HSA:1588] [KO:K07434]
  Pathway
hsa00140  Steroid hormone biosynthesis  
 
Interaction
Genomic biomarker: ESR [HSA:2099 2100], PGR [HSA:5241]
CYP inhibition: CYP1A2 [HSA:1544], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Drug interaction
Structure map
Antineoplastics - hormones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L02 ENDOCRINE THERAPY
   L02B HORMONE ANTAGONISTS AND RELATED AGENTS
    L02BG Aromatase inhibitors
     L02BG03 Anastrozole
      D00960  Anastrozole (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Antineoplastics
  Aromatase Inhibitors, 3rd Generation
   Anastrozole
    D00960  Anastrozole (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D00960  Anastrozole (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   aromatase
    Anastrozole
     D00960  Anastrozole (JAN/USAN/INN)
Antineoplastics [BR:br08308]
 Hormones and hormone antagonists
  Aromatase inhibitor
   Anastrozole
    D00960  Anastrozole (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Anastrozole
    D00960  Anastrozole (JAN/USAN/INN)
 Inhbitors
  CYP1A2
   Anastrozole
    D00960  Anastrozole (JAN/USAN/INN)
  CYP3A4
   Anastrozole
    D00960  Anastrozole (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
120511-73-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8x C     8.8900  -10.7800
            2   C8y C     8.8900  -12.1800
            3   C8x C    10.1024  -12.8800
            4   C8y C    11.3149  -12.1800
            5   C8x C    11.3149  -10.7800
            6   C8y C    10.1024  -10.0800
            7   C1b C    10.1024   -8.6802
            8   N4y N    11.2980   -7.9898
            9   C1d C     7.6776  -12.8800
            10  C1d C    12.5460  -12.8910
            11  C3b C    13.7584  -13.5910
            12  C1a C    11.8467  -14.1019
            13  C1a C    13.2468  -11.6774
            14  N3a N    14.9709  -14.2910
            15  C3b C     6.4651  -13.5800
            16  C1a C     6.9834  -11.6773
            17  C1a C     8.3830  -14.1021
            18  N3a N     5.2527  -14.2800
            19  N5x N    12.6279   -8.4272
            20  C8x C    13.4536   -7.2966
            21  N5x N    12.6335   -6.1620
            22  C8x C    11.3009   -6.5913
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     2   9 1
            10    4  10 1
            11   10  11 1
            12   10  12 1
            13   10  13 1
            14   11  14 3
            15    9  15 1
            16    9  16 1
            17    9  17 1
            18   15  18 3
            19    8  19 1
            20   19  20 2
            21   20  21 1
            22   21  22 2
            23    8  22 1

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