| Entry |
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| Name |
Bicalutamide (JAN/USP/INN);
Casodex (TN)
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| Product |
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| Generic |
BICALUTAMIDE (Accord Healthcare), BICALUTAMIDE (American Health Packaging), BICALUTAMIDE (American Health Packaging), BICALUTAMIDE (Apotex Corp.), BICALUTAMIDE (Breckenridge Pharmaceutical), BICALUTAMIDE (Cadila Healthcare Limited), BICALUTAMIDE (Dava Pharmaceuticals), BICALUTAMIDE (Golden State Medical Supply), BICALUTAMIDE (Major Pharmaceuticals), BICALUTAMIDE (Mylan Pharmaceuticals), BICALUTAMIDE (Northstar Rx LLC), BICALUTAMIDE (Physicians Total Care), BICALUTAMIDE (SUN PHARMA GLOBAL), BICALUTAMIDE (Sandoz), BICALUTAMIDE (Synthon Pharmaceuticals), BICALUTAMIDE (Teva Pharmaceuticals USA), BICALUTAMIDE (UDL Laboratories), BICALUTAMIDE (Zydus Pharmaceuticals (USA)) |
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| Formula |
C18H14F4N2O4S
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| Exact mass |
430.061
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| Mol weight |
430.3734
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| Structure |
     |
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| Activity |
Antineoplastic, Antiandrogen [DS: H00024]
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| Remark |
Same as: Therapeutic category: ATC code: |
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| Target |
androgen receptor antagonist [HSA: 367] [KO: K08557] |
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| Pathway |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| Antineoplastics - hormones | | Progesterone, androgen and estrogen receptor agonists/antagonists |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
429 Miscellaneous
4291 Other Antitumors
D00961 Bicalutamide (JAN/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L02 ENDOCRINE THERAPY
L02B HORMONE ANTAGONISTS AND RELATED AGENTS
L02BB Anti-androgens
L02BB03 Bicalutamide
D00961 Bicalutamide (JAN/USP/INN)
USP drug classification [BR:br08302]
Hormonal Agents
Hormonal Agents, Suppressant (Sex Hormones/ Modifiers)
Antiandrogens
Bicalutamide
D00961 Bicalutamide (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
androgen receptor [HSA:367] [KO:K08557]
Bicalutamide [ATC:L02BB03]
D00961 Bicalutamide (JAN/USP/INN)
Antineoplastics [BR:br08308]
Hormones and hormone antagonist
Androgen antagonist
Bicalutamide [ATC:L02BB03]
D00961 Bicalutamide (JAN/USP/INN)
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| Other DBs |
CAS: 90357-06-5 PubChem: DrugBank: PDB-CCD: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 29
1 C8y C 41.7900 -19.3200
2 C8y C 41.7900 -20.7200
3 C8x C 40.5300 -18.6200
4 C1d C 42.9800 -18.6200
5 C8x C 40.5300 -21.4200
6 C3b C 42.9800 -21.4200
7 C8y C 39.3400 -19.3200
8 X F 44.1700 -17.9200
9 X F 42.2800 -17.4300
10 X F 43.6800 -19.8100
11 C8x C 39.3400 -20.7200
12 N3a N 44.1700 -22.1200
13 N1b N 38.1500 -18.6200
14 C5a C 36.9600 -19.3200
15 C1d C 35.7000 -18.6200
16 O5a O 36.9600 -20.7200
17 C1b C 34.5100 -19.3200
18 C1a C 35.7000 -17.2200
19 S4a S 33.3200 -18.6200
20 C8y C 32.0600 -19.3200
21 O3c O 32.3400 -17.6400
22 O3c O 34.2300 -17.5700
23 O1a O 35.7000 -20.0200
24 C8x C 32.0600 -20.7200
25 C8x C 30.8700 -21.4200
26 C8y C 29.6800 -20.7200
27 C8x C 29.6800 -19.3200
28 C8x C 30.8700 -18.6200
29 X F 28.4200 -21.4200
BOND 30
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 4 8 1
8 4 9 1
9 4 10 1
10 5 11 1
11 6 12 3
12 7 13 1
13 13 14 1
14 14 15 1
15 14 16 2
16 15 17 1
17 15 18 1 #Down
18 17 19 1
19 19 20 1
20 19 21 2
21 19 22 2
22 7 11 2
23 15 23 1 #Up
24 20 24 2
25 24 25 1
26 25 26 2
27 26 27 1
28 27 28 2
29 20 28 1
30 26 29 1
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