| Entry |
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| Name |
Exemestane (JAN/USP/INN);
Aromasin (TN)
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| Product |
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| Generic |
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| Formula |
C20H24O2
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| Exact mass |
296.1776
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| Mol weight |
296.4034
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| Structure |
     |
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| Activity |
Antineoplastic used to treat advanced breast cancer [aromatase inhibitor] [DS: H00031]
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| Remark |
Same as: Therapeutic category: ATC code: |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
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| Interaction |
Genomic biomarker: ESR [HSA: 2099 2100] positive, PGR [HSA: 5241] positive
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| Structure map |
| Antineoplastics - hormones |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
429 Miscellaneous
4291 Other Antitumors
D00963 Exemestane (JAN/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L02 ENDOCRINE THERAPY
L02B HORMONE ANTAGONISTS AND RELATED AGENTS
L02BG Aromatase inhibitors
L02BG06 Exemestane
D00963 Exemestane (JAN/USP/INN)
USP drug classification [BR:br08302]
Antineoplastics
Aromatase Inhibitors, 3rd Generation
Exemestane
D00963 Exemestane (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases
aromatase [HSA:1588] [KO:K07434]
Exemestane [ATC:L02BG06]
D00963 Exemestane (JAN/USP/INN)
Antineoplastics [BR:br08308]
Hormones and hormone antagonist
Aromatase inhibitor
Exemestane [ATC:L02BG06]
D00963 Exemestane (JAN/USP/INN)
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| Other DBs |
CAS: 107868-30-4 PubChem: DrugBank: PDB-CCD: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 22
1 C2x C 12.2500 -16.2400
2 C5x C 12.2500 -17.6400
3 C2x C 13.4624 -18.3400
4 C2y C 14.6749 -17.6400
5 C1z C 14.6749 -16.2400
6 C2x C 13.4624 -15.5400
7 C2y C 15.8873 -18.3400
8 C1x C 17.0997 -17.6400
9 C1y C 17.0997 -16.2400
10 C1y C 15.8873 -15.5400
11 C1y C 18.3122 -15.5400
12 C1z C 18.3122 -14.1400
13 C1x C 17.0997 -13.4400
14 C1x C 15.8873 -14.1400
15 C1x C 20.7370 -15.5400
16 C1x C 20.7370 -14.1400
17 C5x C 19.5246 -13.4400
18 O5x O 19.5246 -12.0400
19 O5x O 11.0376 -18.3400
20 C2a C 15.8873 -19.7400
21 C1a C 14.6749 -14.8400
22 C1a C 18.3122 -12.7400
BOND 25
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 17 18 2
22 2 19 2
23 7 20 2
24 5 21 1 #Up
25 12 22 1 #Up
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