KEGG   DRUG: D00970Help
Entry
D00970                      Drug                                   

Name
Naproxen sodium (USP);
Anaprox (TN)
Product
  Generic
NAPROXEN (Altura Pharmaceuticals), NAPROXEN SODIUM (H.J. Harkins Company), NAPROXEN (REMEDYREPACK), NAPROXEN SODIUM (Aidarex Pharmaceuticals LLC), NAPROXEN SODIUM (Amneal Pharmaceuticals), NAPROXEN SODIUM (Atlantic Biologicals Corps), NAPROXEN SODIUM (Aurobindo Pharma Limited), NAPROXEN SODIUM (AvKARE), NAPROXEN SODIUM (AvPAK), NAPROXEN SODIUM (Blenheim Pharmacal), GOOD SENSE ALL DAY PAIN RELIEF (Bryant Ranch Prepack), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (DIRECT RX), NAPROXEN SODIUM (Glenmark Generics), NAPROXEN SODIUM (Hikma Pharmaceutical), NAPROXEN SODIUM (Keltman Pharmaceuticals), NAPROXEN SODIUM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), NAPROXEN SODIUM (Major Pharmaceuticals), NAPROXEN SODIUM (New Horizon Rx Group), NAPROXEN SODIUM (PD-Rx Pharmaceuticals), NAPROXEN SODIUM (PD-Rx Pharmaceuticals), NAPROXEN SODIUM (PD-Rx Pharmaceuticals), NAPROXEN SODIUM (Physicians Total Care), NAPROXEN SODIUM (Preferred Pharmaceuticals), NAPROXEN SODIUM (REMEDYREPACK), NAPROXEN SODIUM (REMEDYREPACK), NAPROXEN SODIUM (REMEDYREPACK), NAPROXEN SODIUM (Rebel Distributors Corp), NAPROXEN SODIUM (STAT Rx USA LLC), NAPROXEN SODIUM (STAT Rx USA LLC), NAPROXEN SODIUM (State of Florida DOH Central Pharmacy), NAPROXEN SODIUM (State of Florida DOH Central Pharmacy), NAPROXEN SODIUM (Teva Pharmaceuticals USA), NAPROXEN SODIUM (Unit Dose Services), NAPROXEN (West-Ward Pharmaceutical Corp), NAPROXEN SODIUM (bryant ranch prepack), NAPROXEN SODIUM (bryant ranch prepack)
Formula
C14H13O3. Na
Exact mass
252.0762
Mol weight
252.241
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-inflammatory;
Analgesic;
Antipyretic [DS:H00445 H00630]
Remark
ATC code: 
Drug group: 
Comment
Indications: Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis, Juvenile arthritis, etc.
Target
cyclooxygenase-1 (COX-1) inhibitor [HSA:5742] [KO:K00509];
cyclooxygenase-2 (COX-2) inhibitor [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
Antimigraines
Naphthalene family
Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CC Antiinflammatory products for vaginal administration
     G02CC02 Naproxen
      D00970  Naproxen sodium (USP)
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE02 Naproxen
      D00970  Naproxen sodium (USP)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA12 Naproxen
      D00970  Naproxen sodium (USP)
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Naproxen
    D00970  Naproxen sodium (USP)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Naproxen
    D00970  Naproxen sodium (USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   cyclooxygenase-1 (COX-1)
    Naproxen
     D00970  Naproxen sodium (USP)
   cyclooxygenase-2 (COX-2)
    Naproxen
     D00970  Naproxen sodium (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Naproxen
    D00970  Naproxen sodium (USP)
  CYP2C9
   Naproxen
    D00970  Naproxen sodium (USP)
BRITE hierarchy
Other DBs
CAS: 
26159-34-2
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        18
            1   C8y C    23.5997  -20.0988
            2   C8y C    23.5997  -21.4993
            3   C8x C    24.7901  -19.3985
            4   C8x C    22.3393  -19.3985
            5   C8x C    22.3393  -22.1995
            6   C8x C    24.7901  -22.1995
            7   C8y C    25.9806  -20.0988
            8   C8x C    21.1489  -20.0988
            9   C8y C    21.1489  -21.4993
            10  C8x C    25.9806  -21.4993
            11  C1c C    27.2410  -19.3985
            12  O2a O    19.9584  -22.1995
            13  C6a C    28.4314  -20.0988
            14  C1a C    27.2410  -17.9980
            15  C1a C    18.6980  -21.4993
            16  O6a O    28.4314  -21.4993
            17  O6a O    29.6219  -19.3985 #-
            18  Z   Na   31.5125  -19.3985 #+
BOND        18
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     5   9 2
            9     6  10 2
            10    7  11 1
            11    9  12 1
            12   11  13 1
            13   11  14 1 #Down
            14   12  15 1
            15   13  16 2
            16   13  17 1
            17    7  10 1
            18    8   9 1

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