| Entry |
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| Name |
Leuprorelin acetate (JAN);
Leuprolide acetate (USAN);
Lupron (TN);
Lutrate (TN)
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| Product |
|
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| Generic |
|
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| Formula |
C59H84N16O12. C2H4O2
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| Exact mass |
1268.6666
|
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| Mol weight |
1269.4502
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| Structure |
     |
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| Activity |
Antineoplastic;
LHRH agonist [DS: H00024]
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| Remark |
Therapeutic category: ATC code: |
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| Comment |
Leuprorelin cause downregulation of gonadotropin-releasing hormone (GnRH) receptor.
|
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| Target |
gonadotropin-releasing hormone (GnRH) receptor agonist [HSA: 2798] [KO: K04280] |
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| Pathway |
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| Interaction |
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| Structure map |
| Antineoplastics - hormones |
|
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
249 Miscellaneous
2499 Others
D00989 Leuprorelin acetate (JAN); Leuprolide acetate (USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L02 ENDOCRINE THERAPY
L02A HORMONES AND RELATED AGENTS
L02AE Gonadotropin releasing hormone analogues
L02AE02 Leuprorelin
D00989 Leuprorelin acetate (JAN); Leuprolide acetate (USAN)
USP drug classification [BR:br08302]
Hormonal Agents
Hormonal Agents, Suppressant (Pituitary)
Gonadotropin-releasing Hormone (GnRH) Agonists
Leuprolide
D00989 Leuprorelin acetate (JAN); Leuprolide acetate (USAN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Gonadotropin-releasing hormone
gonadotropin-releasing hormone (GnRH) receptor [HSA:2798] [KO:K04280]
Leuprorelin [ATC:L02AE02]
D00989 Leuprorelin acetate (JAN); Leuprolide acetate (USAN)
Antineoplastics [BR:br08308]
Hormones and hormone antagonist
Lutenizing hormone-releasing hormone agonist
Leuprorelin [ATC:L02AE02]
D00989 Leuprorelin acetate (JAN); Leuprolide acetate (USAN)
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| Other DBs |
CAS: 74381-53-6 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 91
1 C6a C 17.2659 -15.4940
2 C1a C 16.0590 -16.1931
3 O6a O 18.4631 -16.1834
4 O6a O 17.2562 -14.1051
5 C8y C 14.3385 -7.1743
6 C8y C 14.7429 -5.8670
7 C1b C 13.1629 -7.8703
8 C8x C 15.4578 -7.9643
9 C8y C 16.1067 -5.8482
10 C8x C 14.0469 -4.6915
11 C1c C 13.1818 -9.5965
12 N4x N 16.5487 -7.1366
13 C8x C 16.7743 -4.6631
14 C8x C 14.7148 -3.4971
15 N1b N 12.0062 -10.2830
16 C5a C 14.3761 -10.2454
17 C8x C 16.0878 -3.4876
18 C5a C 10.8116 -9.6153
19 N1b N 15.5516 -9.5495
20 O5a O 14.3169 -11.6091
21 C1c C 9.6361 -10.3018
22 O5a O 10.7822 -8.2423
23 C1c C 16.7366 -10.2077
24 C1b C 9.6561 -12.5749
25 N1b N 8.4417 -9.6437
26 C5a C 17.9217 -9.5212
27 C1b C 16.7555 -11.5902
28 C8y C 10.9193 -13.2614
29 C5a C 7.2659 -10.3394
30 N1b N 19.1257 -10.1984
31 O5a O 17.9030 -8.1386
32 O1a O 17.9501 -12.2582
33 C1y C 6.0716 -9.6718
34 O5a O 7.2848 -11.7126
35 C1c C 20.3011 -9.4931
36 C1x C 4.8301 -10.2360
37 N1x N 5.9118 -8.3080
38 C1b C 20.3107 -8.1294
39 C5a C 21.5051 -10.1704
40 C1x C 3.8990 -9.2392
41 C5x C 4.5950 -8.0446
42 C8y C 21.4175 -7.4145
43 N1b N 22.6994 -9.4836
44 O5a O 21.5238 -11.5621
45 O5x O 4.0026 -6.8033
46 C8x C 22.6994 -8.0918
47 C8x C 21.4486 -6.0415
48 C1c C 23.9129 -10.1704
49 C8x C 23.8857 -7.3864
50 C8x C 22.6432 -5.3455
51 C5a C 25.1072 -9.4647
52 C1b C 23.9221 -12.4963
53 C8y C 23.8564 -6.0132
54 N1b N 26.3110 -10.1515
55 O5a O 25.1570 -8.0918
56 O1a O 25.0319 -5.3079
57 C1c C 27.4773 -9.4459
58 C5a C 28.6620 -10.1231
59 C1b C 27.5285 -7.6698
60 N1b N 29.8660 -9.4366
61 O5a O 28.6217 -11.5152
62 C1c C 28.6340 -6.9741
63 C1c C 31.0698 -10.1231
64 C1a C 28.6340 -5.6008
65 C1a C 29.8379 -7.6606
66 C5a C 32.2642 -9.4082
67 C1b C 31.0698 -11.4964
68 N1y N 33.4681 -10.0762
69 O5a O 32.2642 -8.0257
70 C1b C 29.8848 -12.1733
71 C1y C 34.8318 -10.0762
72 C1x C 33.0448 -11.3834
73 C1b C 29.8848 -13.5466
74 C1x C 35.2551 -11.3834
75 C5a C 36.1298 -9.3709
76 C1x C 34.1453 -12.1828
77 N1b N 28.6997 -14.2331
78 N1b N 37.3805 -10.1420
79 O5a O 36.0879 -7.8942
80 C2c C 27.5242 -13.5466
81 C1b C 37.3618 -11.6091
82 N1a N 27.5150 -12.1828
83 N2a N 26.3487 -14.2427
84 C1a C 38.5330 -12.3157
85 C1c C 22.7338 -13.1942
86 C1a C 21.5527 -12.5244
87 C1a C 22.7445 -14.6014
88 C8x C 11.0975 -14.6187
89 N5x N 12.4435 -14.8686
90 C8x C 13.0971 -13.6658
91 N4x N 12.1551 -12.6724
BOND 95
1 1 2 1
2 1 3 1
3 1 4 2
4 5 6 1
5 5 7 1
6 5 8 2
7 6 9 2
8 6 10 1
9 7 11 1
10 8 12 1
11 9 13 1
12 10 14 2
13 11 15 1
14 11 16 1
15 13 17 2
16 15 18 1
17 16 19 1
18 16 20 2
19 18 21 1
20 18 22 2
21 19 23 1
22 21 24 1
23 21 25 1
24 23 26 1
25 23 27 1
26 24 28 1
27 25 29 1
28 26 30 1
29 26 31 2
30 27 32 1
31 29 33 1
32 29 34 2
33 30 35 1
34 33 36 1
35 33 37 1
36 35 38 1
37 35 39 1
38 36 40 1
39 37 41 1
40 38 42 1
41 39 43 1
42 39 44 2
43 41 45 2
44 42 46 2
45 42 47 1
46 43 48 1
47 46 49 1
48 47 50 2
49 48 51 1
50 48 52 1
51 49 53 2
52 51 54 1
53 51 55 2
54 53 56 1
55 54 57 1
56 57 58 1
57 57 59 1
58 58 60 1
59 58 61 2
60 59 62 1
61 60 63 1
62 62 64 1
63 62 65 1
64 63 66 1
65 63 67 1
66 66 68 1
67 66 69 2
68 67 70 1
69 68 71 1
70 68 72 1
71 70 73 1
72 71 74 1
73 71 75 1
74 72 76 1
75 73 77 1
76 75 78 1
77 75 79 2
78 77 80 1
79 78 81 1
80 80 82 1
81 80 83 2
82 9 12 1
83 14 17 1
84 40 41 1
85 50 53 1
86 74 76 1
87 81 84 1
88 52 85 1
89 85 86 1
90 85 87 1
91 28 88 2
92 88 89 1
93 89 90 2
94 90 91 1
95 28 91 1
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