KEGG   DRUG: D00997Help
Entry
D00997                      Drug                                   

Name
Tolazoline hydrochloride (JAN/USP);
Priscoline (TN)
Formula
C10H12N2. HCl
Exact mass
196.0767
Mol weight
196.6766
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Vasodilator [peripheral]
Remark
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
alpha2-adrenergic receptor antagonist [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C04 PERIPHERAL VASODILATORS
   C04A PERIPHERAL VASODILATORS
    C04AB Imidazoline derivatives
     C04AB02 Tolazoline
      D00997  Tolazoline hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Tolazoline
      D00997  Tolazoline hydrochloride (JAN/USP)
    alpha2-adrenergic receptor
     Tolazoline
      D00997  Tolazoline hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
59-97-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        13
            1   X   Cl   18.6900  -23.3800
            2   C8x C    15.4700  -21.9800
            3   C8x C    15.4700  -23.3800
            4   C8x C    14.2800  -24.0800
            5   C8x C    13.0200  -23.3800
            6   C8x C    13.0200  -21.9800
            7   C8y C    14.2800  -21.2800
            8   C1b C    14.2800  -19.8800
            9   C2y C    15.4700  -19.1800
            10  N2x N    15.4700  -17.7800
            11  C1x C    16.8000  -17.3600
            12  C1x C    17.6400  -18.4800
            13  N1x N    16.8000  -19.6000
BOND        13
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 2
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13    9  13 1

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