KEGG   DRUG: Tolazoline hydrochlorideHelp
Entry
D00997                      Drug                                   

Name
Tolazoline hydrochloride (JAN/USP);
Priscoline (TN)
Formula
C10H12N2. HCl
Exact mass
196.0767
Mol weight
196.6766
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
   DG01460  alpha2-Adrenergic receptor antagonist
Remark
ATC code: 
Chemical group: 
Activity
Vasodilator (peripheral), alpha-Adrenergic receptor antagonist
Comment
Imidazoline derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137];
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Salivary secretion
Interaction
Drug interaction
Structure map
alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C04 PERIPHERAL VASODILATORS
   C04A PERIPHERAL VASODILATORS
    C04AB Imidazoline derivatives
     C04AB02 Tolazoline
      D00997  Tolazoline hydrochloride (JAN/USP)
 M MUSCULO-SKELETAL SYSTEM
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AX Other topical products for joint and muscular pain
     M02AX02 Tolazoline
      D00997  Tolazoline hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Tolazoline
      D00997  Tolazoline hydrochloride (JAN/USP)
    alpha2-adrenergic receptor
     Tolazoline
      D00997  Tolazoline hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
59-97-2
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        13
            1   X   Cl   18.6900  -23.3800
            2   C8x C    15.4700  -21.9800
            3   C8x C    15.4700  -23.3800
            4   C8x C    14.2800  -24.0800
            5   C8x C    13.0200  -23.3800
            6   C8x C    13.0200  -21.9800
            7   C8y C    14.2800  -21.2800
            8   C1b C    14.2800  -19.8800
            9   C2y C    15.4700  -19.1800
            10  N2x N    15.4700  -17.7800
            11  C1x C    16.8000  -17.3600
            12  C1x C    17.6400  -18.4800
            13  N1x N    16.8000  -19.6000
BOND        13
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 2
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13    9  13 1

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