KEGG   DRUG: Neostigmine methylsulfateHelp
Entry
D00998                      Drug                                   

Name
Neostigmine methylsulfate (JP17/USP);
Bloxiverz (TN);
Prostigmin (TN)
Product
  Generic
  Other
Formula
C12H19N2O2. CH3SO4
Exact mass
334.1199
Mol weight
334.3886
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
Other
 DG01719  Parasympathomimetic agent
Remark
Same as: 
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Acetylcholinesterase inhibitor
Comment
Reversible cholinesterase inhibitor
Physostigmine derivative
Target
acetylcholinesterase (AChE) inhibitor [HSA:43] [KO:K01049]
  Pathway
Glycerophospholipid metabolism
Cholinergic synapse
Interaction
Drug interaction
Structure map
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AA Anticholinesterases
     N07AA01 Neostigmine
      D00998  Neostigmine methylsulfate (JP17/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB06 Neostigmine
      D00998  Neostigmine methylsulfate (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   123  Autonomic nervous system agents
    1233  Neostigmines
     D00998  Neostigmine methylsulfate (JP17/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for ophthalmologic use
  62 General eye drops
   D00998  Neostigmine methylsulfate (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Third-class OTC drugs
  Inorganic and organic chemicals
   Neostigmine
    D00998  Neostigmine methylsulfate (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   acetylcholinesterase (AChE)
    Neostigmine
     D00998  Neostigmine methylsulfate (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00998  Neostigmine methylsulfate
  D00998  Neostigmine methylsulfate injection
BRITE hierarchy
Other DBs
CAS: 
51-60-5
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8y C    21.6932  -17.0217
            2   C8x C    22.9128  -16.3157
            3   C8x C    21.6932  -18.4279
            4   O7a O    20.4737  -16.3214
            5   C8y C    24.1207  -17.0217
            6   C8x C    22.9128  -19.1281
            7   C7a C    19.2600  -17.0274
            8   C8x C    24.1207  -18.4221
            9   N1d N    25.3402  -16.3157 #+
            10  N1c N    18.0405  -16.3274
            11  O6a O    19.2600  -18.4338
            12  C1a C    26.7988  -15.3937
            13  C1a C    24.6750  -15.2537
            14  C1a C    26.1630  -17.5234
            15  C1a C    16.8326  -17.0334
            16  C1a C    18.0405  -14.9210
            17  S4a S    32.7856  -17.4302
            18  O2a O    31.4201  -17.4243
            19  O1d O    32.7739  -18.7022
            20  O1d O    32.7272  -15.8138
            21  O1d O    34.1686  -17.4302 #-
            22  C1a C    30.6791  -16.3389
BOND        21
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     7  10 1
            10    7  11 2
            11    9  12 1
            12    9  13 1
            13    9  14 1
            14   10  15 1
            15   10  16 1
            16    6   8 1
            17   17  18 1
            18   17  19 2
            19   17  20 2
            20   17  21 1
            21   18  22 1

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