| Entry |
|
|---|
| Name |
Neostigmine methylsulfate (JP16/USP);
Prostigmin (TN)
|
|---|
| Product |
|
|---|
| Other |
|
|---|
| Formula |
C12H19N2O2. CH3SO4
|
|---|
| Exact mass |
334.1199
|
|---|
| Mol weight |
334.3886
|
|---|
| Structure |
     |
|---|
| Activity |
Cholinergic
|
|---|
| Remark |
Same as: Therapeutic category: ATC code: |
|---|
| Comment |
Reversible cholinesterase inhibitor
|
|---|
| Target |
acetylcholinesterase (AChE) inhibitor [HSA: 43] [KO: K01049] |
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Structure map |
| Cholinergic and anticholinergic drugs |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
12 Agents affecting peripheral nervous system
123 Autonomic nervous system agents
1233 Neostigmines
D00998 Neostigmine methylsulfate (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07A PARASYMPATHOMIMETICS
N07AA Anticholinesterases
N07AA01 Neostigmine
D00998 Neostigmine methylsulfate (JP16/USP)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EB Parasympathomimetics
S01EB06 Neostigmine
D00998 Neostigmine methylsulfate (JP16/USP)
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases
acetylcholinesterase (AChE) [HSA:43] [KO:K01049]
Neostigmine [ATC:N07AA01 S01EB06]
D00998 Neostigmine methylsulfate (JP16/USP)
 |
|---|
| Other DBs |
CAS: 51-60-5 PubChem: LigandBox: NIKKAJI: |
|---|
| KCF data |
ATOM 22
1 C8y C 21.6932 -17.0217
2 C8x C 22.9128 -16.3157
3 C8x C 21.6932 -18.4279
4 O7a O 20.4737 -16.3214
5 C8y C 24.1207 -17.0217
6 C8x C 22.9128 -19.1281
7 C7a C 19.2600 -17.0274
8 C8x C 24.1207 -18.4221
9 N1d N 25.3402 -16.3157 #+
10 N1c N 18.0405 -16.3274
11 O6a O 19.2600 -18.4338
12 C1a C 26.7988 -15.3937
13 C1a C 24.6750 -15.2537
14 C1a C 26.1630 -17.5234
15 C1a C 16.8326 -17.0334
16 C1a C 18.0405 -14.9210
17 S4a S 32.7856 -17.4302
18 O2a O 31.4201 -17.4243
19 O1d O 32.7739 -18.7022
20 O1d O 32.7272 -15.8138
21 O1d O 34.1686 -17.4302 #-
22 C1a C 30.6791 -16.3389
BOND 21
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 3 6 2
6 4 7 1
7 5 8 2
8 5 9 1
9 7 10 1
10 7 11 2
11 9 12 1
12 9 13 1
13 9 14 1
14 10 15 1
15 10 16 1
16 6 8 1
17 17 18 1
18 17 19 2
19 17 20 2
20 17 21 1
21 18 22 1
|
|---|
