KEGG   DRUG: D01004Help
Entry
D01004                      Drug                                   

Name
Homatropine hydrobromide (JP16/USP);
Isopto homatropine (TN)
Product
  Other
Formula
C16H21NO3. HBr
Exact mass
355.0783
Mol weight
356.2548
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticholinergic [ophthalmic]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Structure map
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01F MYDRIATICS AND CYCLOPLEGICS
    S01FA Anticholinergics
     S01FA05 Homatropine
      D01004  Homatropine hydrobromide (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1311  Mydriatic agents
     D01004  Homatropine hydrobromide (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Homatropine
      D01004  Homatropine hydrobromide (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01004  Homatropine hydrobromide
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from ornithine
   Tropane alkaloids
    D01004  Homatropine hydrobromide (JP15/USP)
BRITE hierarchy
Other DBs
CAS: 
51-56-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   X   Br   35.9441  -16.6432
            2   C1x C    26.0638  -19.5108
            3   C1x C    26.3919  -18.3391
            4   C1y C    27.2355  -19.2296
            5   C1y C    27.5636  -18.0579
            6   N1y N    26.2982  -16.7456
            7   C1x C    29.1102  -19.2296
            8   C1x C    28.8290  -18.0579
            9   C1y C    30.1413  -19.7920
            10  O7a O    31.2193  -20.6825
            11  C7a C    32.4379  -20.6825
            12  C1c C    33.0472  -19.6045
            13  O6a O    33.0472  -21.8073
            14  C8y C    34.2658  -19.6045
            15  O1a O    32.4379  -18.5734
            16  C8x C    34.9720  -20.8282
            17  C8x C    36.3720  -20.8285
            18  C8x C    37.0722  -19.6162
            19  C8x C    36.3661  -18.3925
            20  C8x C    34.9661  -18.3922
            21  C1a C    25.5491  -15.5614
BOND        22
            1     2   3 1
            2     2   4 1
            3     3   5 1
            4     4   6 1
            5     4   7 1
            6     5   8 1
            7     7   9 1
            8     9  10 1 #Down
            9    10  11 1
            10   11  12 1
            11   11  13 2
            12   12  14 1
            13   12  15 1
            14    5   6 1
            15    8   9 1
            16   14  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   14  20 1
            22    6  21 1

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