KEGG   DRUG: D01010Help
Entry
D01010                      Drug                                   

Name
Levothyroxine sodium hydrate (JP16);
Levothyroxine sodium (USP);
Levothroid (TN);
Levoxyl (TN);
Synthroid (TN);
Synthroid (TN)
Product
SYNTHROID (A-S Medication Solutions LLC), SYNTHROID (AbbVie), LEVOTHYROXINE SODIUM (Aidarex Pharmaceuticals LLC), TIROSINT (Akrimax Pharmaceuticals), SYNTHROID (Aphena Pharma Solutions - Tennessee), SYNTHROID (Aphena Pharma Solutions - Tennessee), LEVOTHYROXINE SODIUM (Bryant Ranch Prepack), LEVOTHYROXINE SODIUM (Bryant Ranch Prepack), LEVOTHYROXINE SODIUM (Bryant Ranch Prepack), LEVOTHYROXINE SODIUM (Bryant Ranch Prepack), LEVOTHYROXINE SODIUM (Bryant Ranch Prepack), LEVOTHYROXINE SODIUM (Bryant Ranch Prepack), LEVOTHYROXINE SODIUM (Bryant Ranch Prepack), LEVOTHYROXINE SODIUM (Bryant Ranch Prepack), LEVOTHYROXINE SODIUM (Bryant Ranch Prepack), LEVOTHYROXINE SODIUM (Bryant Ranch Prepack), LEVOXYL (Cardinal Health), LEVOTHYROXINE SODIUM (Clinical Solutions Wholesale), SYNTHROID (Dispensing Solutions), SYNTHROID (Dispensing Solutions), SYNTHROID (Dispensing Solutions), LEVOTHYROXINE SODIUM (Dispensing Solutions), LEVOTHYROXINE SODIUM (Dispensing Solutions), SYNTHROID (Dispensing Solutions), LEVOXYL (Dispensing Solutions), SYNTHROID (Dispensing Solutions), LEVOTHYROXINE SODIUM (Dispensing Solutions), UNITHROID (Gemini Laboratories), LEVOTHYROXINE SODIUM (H.J. Harkins Company), LEVOTHYROXINE SODIUM (Lake Erie Medical DBA Quality Care Products LLC), LEVOTHYROXINE SODIUM (Lake Erie Medical DBA Quality Care Products LLC), LEVOTHYROXINE SODIUM (Lake Erie Medical DBA Quality Care Products LLC), LEVOTHYROXINE SODIUM (Lake Erie Medical DBA Quality Care Products LLC), LEVOTHYROXINE SODIUM (Lake Erie Medical DBA Quality Care Products LLC), UNITHROID (Lannett Company), LEVOTHYROXINE SODIUM (Lannett Company), LEVOTHYROXINE SODIUM (Med-Health Pharma), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), SYNTHROID (PD-Rx Pharmaceuticals), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), LEVOTHROID (PD-Rx Pharmaceuticals), LEVOTHROID (PD-Rx Pharmaceuticals), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), LEVOTHROID (PD-Rx Pharmaceuticals), SYNTHROID (PD-Rx Pharmaceuticals), LEVOTHROID (PD-Rx Pharmaceuticals), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), LEVOXYL (Pfizer Laboratories Div Pfizer), LEVOTHROID (Physicians Total Care), LEVOXYL (Physicians Total Care), SYNTHROID (Physicians Total Care), LEVOTHYROXINE SODIUM (Preferred Pharmaceuticals), LEVOTHYROXINE SODIUM (Preferred Pharmaceuticals), LEVOTHYROXINE SODIUM (Preferred Pharmaceuticals), LEVOTHYROXINE SODIUM (Preferred Pharmaceuticals), LEVOTHYROXINE SODIUM (Preferred Pharmaceuticals), LEVOTHYROXINE SODIUM (Preferred Pharmaceuticals), LEVOTHYROXINE SODIUM (Preferred Pharmaceuticals), LEVOTHYROXINE SODIUM (Preferred Pharmaceuticals), LEVOTHYROXINE SODIUM (Preferred Pharmaceuticals), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), SYNTHROID (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), SYNTHROID (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), SYNTHROID (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), SYNTHROID (REMEDYREPACK), SYNTHROID (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), SYNTHROID (REMEDYREPACK), SYNTHROID (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), SYNTHROID (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), SYNTHROID (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (Rebel Distributors Corp), LEVOTHYROXINE SODIUM (Rebel Distributors Corp.), LEVOTHYROXINE SODIUM (STAT Rx USA LLC), LEVOTHYROXINE SODIUM (Sandoz), LEVOTHYROXINE SODIUM (St Marys Medical Park Pharmacy), LEVOTHYROXINE SODIUM (St Marys Medical Park Pharmacy), LEVOTHYROXINE SODIUM (St Marys Medical Park Pharmacy), LEVOTHYROXINE SODIUM (St Marys Medical Park Pharmacy), LEVOTHYROXINE SODIUM (State of Florida DOH Central Pharmacy), LEVOTHYROXINE SODIUM (State of Florida DOH Central Pharmacy), LEVOTHYROXINE SODIUM (Unit Dose Services), LEVOTHYROXINE SODIUM (Unit Dose Services), LEVOTHYROXINE SODIUM (Unit Dose Services), LEVOTHYROXINE SODIUM (Unit Dose Services), LEVOTHYROXINE SODIUM (Unit Dose Services), LEVOTHYROXINE SODIUM (Unit Dose Services), LEVOTHYROXINE SODIUM (Unit Dose Services), LEVOTHYROXINE SODIUM (Unit Dose Services), LEVOTHYROXINE SODIUM (Unit Dose Services), LEVOTHYROXINE SODIUM (Fresenius Kabi USA), LEVOTHYROXINE SODIUM (Fresenius Kabi USA), SYNTHROID (Cardinal Health)
  Generic
LEVOTHYROXINE SODIUM (Cardinal Health), LEVOTHYROXINE SODIUM (Mylan Pharmaceuticals), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), LEVOTHYROXINE SODIUM (PD-Rx Pharmaceuticals), LEVOTHYROXINE SODIUM (Physicians Total Care), LEVOTHYROXINE SODIUM (Physicians Total Care), LEVOTHYROXINE SODIUM (Preferred Pharmaceuticals), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (REMEDYREPACK), LEVOTHYROXINE SODIUM (State of Florida DOH Central Pharmacy), LEVOTHYROXINE SODIUM (UDL Laboratories)
Formula
C15H10I4NO4. Na. xH2O
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Thyroid hormone [DS:H00081]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
thyroid hormone receptor, alpha agonist [HSA:7067] [KO:K05547];
thyroid hormone receptor, beta agonist [HSA:7068] [KO:K08362]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Antineoplastics - hormones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H03 THYROID THERAPY
   H03A THYROID PREPARATIONS
    H03AA Thyroid hormones
     H03AA01 Levothyroxine sodium
      D01010  Levothyroxine sodium hydrate (JP16); Levothyroxine sodium (USP)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Thyroid)
  Levothyroxine
   D01010  Levothyroxine sodium hydrate (JP16); Levothyroxine sodium (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   243  Thyroid and parathyroid hormone preparations
    2431  Thyroid hormones
     D01010  Levothyroxine sodium hydrate (JP16); Levothyroxine sodium (USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Thyroid hormone receptor (THR)
    thyroid hormone receptor, alpha
     Levothyroxine sodium
      D01010  Levothyroxine sodium (USP)
    thyroid hormone receptor, beta
     Levothyroxine sodium
      D01010  Levothyroxine sodium (USP)
Antineoplastics [BR:br08308]
 Hormones and hormone antagonists
  Thyroid hormone
   Levothyroxine sodium
    D01010  Levothyroxine sodium hydrate (JP16); Levothyroxine sodium (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01010  Levothyroxine sodium hydrate
  D01010  Levothyroxine sodium tablets
Animal drugs in Japan [BR:br08331]
 96  Agents affecting metabolism
  961  Hormone preparations (except agents for breeding and external use)
   9614  Thyroid and para-thyroid hormone preparations (except agents anti-thyroid)
    D01010  Levothyroxine sodium hydrate
BRITE hierarchy
Other DBs
CAS: 
25416-65-3
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        26
            1   C8y C    28.4332  -19.6165
            2   O2a O    27.2285  -18.9148
            3   C8x C    28.4449  -21.0082
            4   C8x C    29.6494  -18.8914
            5   C8y C    26.0357  -18.2073
            6   C8y C    29.6611  -21.6865
            7   C8y C    30.8657  -19.5697
            8   C8y C    24.8253  -18.9090
            9   C8y C    26.0357  -16.7980
            10  C8y C    30.8774  -20.9731
            11  X   I    29.6787  -23.0782
            12  X   I    32.0645  -18.8505
            13  C8x C    23.6208  -18.2073
            14  X   I    24.8370  -20.3239
            15  C8x C    24.8253  -16.0905
            16  X   I    27.2462  -16.0846
            17  O1a O    32.0996  -21.6514
            18  C8y C    23.6208  -16.7980
            19  C1b C    22.4221  -16.0846
            20  C1c C    21.2234  -16.7863
            21  C6a C    20.0246  -16.0788
            22  N1a N    21.2351  -18.2014
            23  O6a O    20.0304  -14.6696
            24  O6a O    18.8200  -16.7805 #-
            25  O0  O    36.2757  -20.2436
            26  Z   Na   15.7495  -16.8712 #+
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 2
            7     5   8 1
            8     5   9 2
            9     6  10 2
            10    6  11 1
            11    7  12 1
            12    8  13 2
            13    8  14 1
            14    9  15 1
            15    9  16 1
            16   10  17 1
            17   13  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   20  22 1 #Down
            22   21  23 2
            23   21  24 1
            24    7  10 1
            25   15  18 2
BRACKET     1    34.3700  -21.3500   34.3700  -19.0400
            1    36.8200  -19.0400   36.8200  -21.3500
            1  x
 ORIGINAL  1   25
 REPEAT    1

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