KEGG   DRUG: D01011Help
Entry
D01011                      Drug                                   

Name
Liothyronine sodium (JP16/USAN);
Cytomel (TN);
Triostat (TN)
Product
  Generic
Formula
C15H11I3NO4. Na
Exact mass
672.772
Mol weight
672.9553
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Thyroid hormone
Remark
Therapeutic category: 
ATC code: 
Target
thyroid hormone receptor, alpha agonist [HSA:7067] [KO:K05547];
thyroid hormone receptor, beta agonist [HSA:7068] [KO:K08362]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Antineoplastics - hormones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H03 THYROID THERAPY
   H03A THYROID PREPARATIONS
    H03AA Thyroid hormones
     H03AA02 Liothyronine sodium
      D01011  Liothyronine sodium (JP16/USAN)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Thyroid)
  Liothyronine
   D01011  Liothyronine sodium (JP16/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   243  Thyroid and parathyroid hormone preparations
    2431  Thyroid hormones
     D01011  Liothyronine sodium (JP16/USAN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Thyroid hormone receptor (THR)
    thyroid hormone receptor, alpha
     Liothyronine sodium
      D01011  Liothyronine sodium (JP16/USAN)
    thyroid hormone receptor, beta
     Liothyronine sodium
      D01011  Liothyronine sodium (JP16/USAN)
Antineoplastics [BR:br08308]
 Hormones and hormone antagonists
  Thyroid hormone
   Liothyronine sodium
    D01011  Liothyronine sodium (JP16/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01011  Liothyronine sodium
  D01011  Liothyronine sodium tablets
BRITE hierarchy
Other DBs
CAS: 
55-06-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C8y C    22.6938  -17.3834
            2   O2a O    23.9120  -18.0919
            3   C8y C    21.4993  -18.0919
            4   C8y C    22.6938  -15.9897
            5   C8y C    25.1241  -18.7889
            6   C8x C    20.2754  -17.3834
            7   X   I    21.4993  -19.4857
            8   C8x C    21.4993  -15.2870
            9   X   I    23.9120  -15.2870
            10  C8x C    26.3421  -18.0919
            11  C8x C    25.1241  -20.1884
            12  C8y C    20.2754  -15.9897
            13  C8y C    27.5543  -18.7889
            14  C8x C    26.3421  -20.8911
            15  C1b C    19.0632  -15.2870
            16  C8y C    27.5543  -20.1884
            17  X   I    28.7605  -18.0919
            18  C1c C    17.8453  -15.9897
            19  O1a O    28.7605  -20.8911
            20  C6a C    16.6331  -15.2870
            21  N1a N    17.8453  -17.3834
            22  O6a O    16.6331  -13.8875
            23  O6a O    15.4149  -15.9897 #-
            24  Z   Na   13.6172  -13.9050 #+
BOND        24
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12   10  13 2
            13   11  14 1
            14   12  15 1
            15   13  16 1
            16   13  17 1
            17   15  18 1
            18   16  19 1
            19   18  20 1
            20   18  21 1 #Down
            21   20  22 2
            22   20  23 1
            23    8  12 1
            24   14  16 2

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