KEGG   DRUG: D01017Help
Entry
D01017                      Drug                                   

Name
Dipivefrin hydrochloride (JAN/USP);
Propine (TN)
Formula
C19H29NO5. HCl
Exact mass
387.1813
Mol weight
387.8982
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiglaucoma agent [DS:H00612]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
prodrug, active substance: Adrenaline [DR:D00095]
Target
alpha1-adrenergic receptor agonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
alpha2-adrenergic receptor agonist [HSA:150 151 152] [KO:K04138 K04139 K04140];
beta1-adrenergic receptor agonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor agonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor agonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA02 Dipivefrine
      D01017  Dipivefrin hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Dipivefrin
    D01017  Dipivefrin hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1311  Mydriatic agents
     D01017  Dipivefrin hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Dipivefrin
      D01017  Dipivefrin hydrochloride (JAN/USP)
    alpha2-adrenergic receptor
     Dipivefrin
      D01017  Dipivefrin hydrochloride (JAN/USP)
    beta1-adrenergic receptor
     Dipivefrin
      D01017  Dipivefrin hydrochloride (JAN/USP)
    beta2-adrenergic receptor
     Dipivefrin
      D01017  Dipivefrin hydrochloride (JAN/USP)
    beta3-adrenergic receptor
     Dipivefrin
      D01017  Dipivefrin hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
64019-93-8
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   X   Cl   21.9800  -26.1800
            2   C8y C    15.1900  -20.7900
            3   C8y C    15.1900  -22.1900
            4   C8x C    16.3800  -22.8900
            5   C8x C    17.6400  -22.1900
            6   C8y C    17.6400  -20.7900
            7   C8x C    16.3800  -20.0900
            8   O7a O    14.0000  -20.0900
            9   O7a O    14.0000  -22.8900
            10  C1c C    18.8300  -20.0900
            11  C1b C    20.0200  -20.7900
            12  O1a O    18.8300  -18.6900
            13  N1b N    21.2381  -20.0999
            14  C1a C    22.4195  -20.7950
            15  C7a C    14.0114  -18.6900
            16  C7a C    14.0000  -24.2900
            17  C1d C    12.7876  -24.9900
            18  O6a O    15.2124  -24.9900
            19  O6a O    15.2208  -18.0048
            20  C1d C    12.7962  -17.9752
            21  C1a C    11.5824  -18.6630
            22  C1a C    12.8076  -16.5900
            23  C1a C    11.6062  -17.2753
            24  C1a C    11.5921  -24.2996
            25  C1a C    12.7875  -26.3898
            26  C1a C    11.5920  -25.6803
BOND        25
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     2   8 1
            8     3   9 1
            9     6  10 1
            10   10  11 1
            11   10  12 1
            12   11  13 1
            13   13  14 1
            14    8  15 1
            15    9  16 1
            16   16  17 1
            17   16  18 2
            18   15  19 2
            19   15  20 1
            20   20  21 1
            21   20  22 1
            22   20  23 1
            23   17  24 1
            24   17  25 1
            25   17  26 1

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