KEGG   DRUG: D01023Help
Entry
D01023                      Drug                                   

Name
Tetrahydrozoline hydrochloride (JAN/USP);
Tyzine (TN)
Product
  Generic
Formula
C13H16N2. HCl
Exact mass
236.108
Mol weight
236.7405
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Adrenergic [vasoconstrictor]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor agonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA06 Tetryzoline
      D01023  Tetrahydrozoline hydrochloride (JAN/USP)
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB03 Tetryzoline
      D01023  Tetrahydrozoline hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Respiratory Tract Agents, Other
   Tetrahydrozoline
    D01023  Tetrahydrozoline hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   132  Otic and nasal agents
    1324  Otolaryngologic vasoconstrictors
     D01023  Tetrahydrozoline hydrochloride (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for ophthalmologic use
  62 General eye drops
   D01023  Tetrahydrozoline hydrochloride (JAN/USP)
 Agents for otolaryngologic use
  70 Nasal sprays for inflammation
   D01023  Tetrahydrozoline hydrochloride (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Category 2
  Inorganic and organic chemicals
   Tetryzoline
    D01023  Tetrahydrozoline hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Tetryzoline
      D01023  Tetrahydrozoline hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
522-48-5
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   C1y C    18.2700  -16.5200
            2   C8y C    17.0800  -17.2900
            3   C2y C    18.2700  -15.1200
            4   C1x C    19.4600  -17.2200
            5   C8y C    17.0800  -18.6900
            6   C8x C    15.8200  -16.5900
            7   N1x N    19.3900  -14.3500
            8   N2x N    17.1500  -14.3500
            9   C1x C    19.4600  -18.6200
            10  C1x C    18.2700  -19.3200
            11  C8x C    15.8200  -19.3200
            12  C8x C    14.6300  -17.2900
            13  C1x C    18.9700  -13.0200
            14  C1x C    17.5700  -13.0200
            15  C8x C    14.6300  -18.6900
            16  X   Cl   21.4900  -18.0600
BOND        17
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 1
            14   11  15 2
            15    9  10 1
            16   12  15 1
            17   13  14 1

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