KEGG   DRUG: D01024Help
Entry
D01024                      Drug                                   

Name
Tamsulosin hydrochloride (JP16/USAN);
Flomax (TN);
Harnal (TN)
Product
  Generic
TAMSULOSIN HYDROCHLORIDE (Actavis Elizabeth LLC), TAMSULOSIN HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), TAMSULOSIN HYDROCHLORIDE (American Health Packaging), TAMSULOSIN HYDROCHLORIDE (American Health Packaging), TAMSULOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TAMSULOSIN HYDROCHLORIDE (Aurobindo Pharma Limited), TAMSULOSIN HYDROCHLORIDE (Bryant Ranch Prepack), TAMSULOSIN HYDROCHLORIDE (Cadila Healthcare Limited), TAMSULOSIN HYDROCHLORIDE (Cardinal Health), TAMSULOSIN HYDROCHLORIDE (Cardinal Health), TAMSULOSIN HYDROCHLORIDE (Cardinal Health), TAMSULOSIN HYDROCHLORIDE (Carilion Materials Management), TAMSULOSIN HYDROCHLORIDE (Citron Pharma LLC), TAMSULOSIN HYDROCHLORIDE (Clinical Solutions Wholesale), TAMSULOSIN HYDROCHLORIDE (Contract Pharmacy Services-PA), TAMSULOSIN HYDROCHLORIDE (Dispensing Solutions), TAMSULOSIN HYDROCHLORIDE (Global Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (Golden State Medical Supply), TAMSULOSIN HYDROCHLORIDE (H.J. Harkins Company), TAMSULOSIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TAMSULOSIN HYDROCHLORIDE (Major Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (McKesson Contract Packaging), TAMSULOSIN HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), TAMSULOSIN HYDROCHLORIDE (McKesson Packaging Services a business unit of McKesson Corporation), TAMSULOSIN HYDROCHLORIDE (MedVantx), TAMSULOSIN HYDROCHLORIDE (Mylan Institutional), TAMSULOSIN HYDROCHLORIDE (Mylan Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (NCS HealthCare of KY), TAMSULOSIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (Par Pharmaceutical), TAMSULOSIN HYDROCHLORIDE (Physicians Total Care), TAMSULOSIN HYDROCHLORIDE (Preferred Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (Preferred Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (REMEDYREPACK), TAMSULOSIN HYDROCHLORIDE (REMEDYREPACK), TAMSULOSIN HYDROCHLORIDE (REMEDYREPACK), TAMSULOSIN HYDROCHLORIDE (REMEDYREPACK), TAMSULOSIN HYDROCHLORIDE (REMEDYREPACK), TAMSULOSIN HYDROCHLORIDE (REMEDYREPACK), TAMSULOSIN HYDROCHLORIDE (REMEDYREPACK), TAMSULOSIN HYDROCHLORIDE (REMEDYREPACK), TAMSULOSIN HYDROCHLORIDE (REMEDYREPACK), TAMSULOSIN HYDROCHLORIDE (REMEDYREPACK), TAMSULOSIN HYDROCHLORIDE (REMEDYREPACK), TAMSULOSIN HYDROCHLORIDE (Rebel Distributors Corp), TAMSULOSIN HYDROCHLORIDE (STAT RX USA LLC), TAMSULOSIN HYDROCHLORIDE (Sandoz), TAMSULOSIN HYDROCHLORIDE (St Marys Medical Park Pharmacy), TAMSULOSIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), TAMSULOSIN HYDROCHLORIDE (Sun Pharmaceutical Industries Limited), TAMSULOSIN HYDROCHLORIDE (Synthon Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (Teva Pharmaceuticals USA), TAMSULOSIN HYDROCHLORIDE (Unit Dose Services), TAMSULOSIN HYDROCHLORIDE (WOCKHARDT LIMITED), TAMSULOSIN HYDROCHLORIDE (WOCKHARDT USA LLC), TAMSULOSIN HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C20H28N2O5S. HCl
Exact mass
444.1486
Mol weight
444.9727
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Benign prostatic hyperplasia therapy agent
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor (especially alpha-1A) antagonist [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
    G04CA Alpha-adrenoreceptor antagonists
     G04CA02 Tamsulosin
      D01024  Tamsulosin hydrochloride (JP16/USAN)
USP drug classification [BR:br08302]
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Tamsulosin
    D01024  Tamsulosin hydrochloride (JP16/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D01024  Tamsulosin hydrochloride (JP16/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Tamsulosin
      D01024  Tamsulosin hydrochloride (JP16/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01024  Tamsulosin hydrochloride
  D01024  Tamsulosin hydrochloride
BRITE hierarchy
Other DBs
CAS: 
106463-17-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   X   Cl   37.1126  -18.1655
            2   C8y C    23.2273  -16.7222
            3   C1b C    24.4390  -17.4218
            4   C1c C    25.6508  -16.7222
            5   N1b N    26.8625  -17.4218
            6   C1b C    28.0742  -16.7222
            7   C1b C    29.2860  -17.4218
            8   O2a O    30.4976  -16.7222
            9   C8y C    31.7093  -17.4218
            10  C8x C    32.9211  -16.7222
            11  C8x C    23.2273  -15.3230
            12  C8y C    22.0157  -14.6235
            13  C8y C    20.8039  -15.3230
            14  C8x C    20.8039  -16.7222
            15  C8x C    22.0157  -17.4218
            16  C1a C    25.6508  -15.3232
            17  C8y C    31.7093  -18.8210
            18  C8x C    32.9211  -19.5206
            19  C8x C    34.1328  -18.8210
            20  C8x C    34.1328  -17.4218
            21  O2a O    30.4849  -19.5280
            22  O2a O    19.5735  -14.6125
            23  C1a C    18.3690  -15.3078
            24  S4a S    22.0157  -13.2245
            25  O3c O    20.6165  -13.2245
            26  N1a N    22.0157  -11.8245
            27  O3c O    23.4157  -13.2245
            28  C1b C    29.2662  -18.7825
            29  C1a C    28.0412  -19.4489
BOND        29
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     7   8 1
            7     8   9 1
            8     9  10 1
            9     2  11 2
            10   11  12 1
            11   12  13 2
            12   13  14 1
            13   14  15 2
            14    2  15 1
            15    4  16 1 #Up
            16    9  17 2
            17   17  18 1
            18   18  19 2
            19   19  20 1
            20   20  10 2
            21   17  21 1
            22   13  22 1
            23   22  23 1
            24   12  24 1
            25   24  25 2
            26   24  26 1
            27   24  27 2
            28   21  28 1
            29   28  29 1

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