KEGG   DRUG: Tamsulosin hydrochlorideHelp
Entry
D01024                      Drug                                   

Name
Tamsulosin hydrochloride (JP17/USAN);
Flomax (TN);
Harnal (TN)
Product
  Generic
TAMSULOSIN HYDROCHLORIDE (Actavis Pharma), TAMSULOSIN HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), TAMSULOSIN HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), TAMSULOSIN HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), TAMSULOSIN HYDROCHLORIDE (American Health Packaging), TAMSULOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TAMSULOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TAMSULOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TAMSULOSIN HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TAMSULOSIN HYDROCHLORIDE (Ascend Laboratories), TAMSULOSIN HYDROCHLORIDE (Aurobindo Pharma Limited), TAMSULOSIN HYDROCHLORIDE (AvPAK), TAMSULOSIN HYDROCHLORIDE (Avera McKennan Hospital), TAMSULOSIN HYDROCHLORIDE (Blenheim Pharmacal), TAMSULOSIN HYDROCHLORIDE (Blenheim Pharmacal), TAMSULOSIN HYDROCHLORIDE (Bryant Ranch Prepack), TAMSULOSIN HYDROCHLORIDE (Bryant Ranch Prepack), TAMSULOSIN HYDROCHLORIDE (Bryant Ranch Prepack), TAMSULOSIN HYDROCHLORIDE (Bryant Ranch Prepack), TAMSULOSIN HYDROCHLORIDE (Cadila Healthcare Limited), TAMSULOSIN HYDROCHLORIDE (Cardinal Health), TAMSULOSIN HYDROCHLORIDE (Cardinal Health), TAMSULOSIN HYDROCHLORIDE (Carilion Materials Management), TAMSULOSIN HYDROCHLORIDE (Clinical Solutions Wholesale), TAMSULOSIN HYDROCHLORIDE (Contract Pharmacy Services-PA), TAMSULOSIN HYDROCHLORIDE (Contract Pharmacy Services-PA), TAMSULOSIN HYDROCHLORIDE (DirectRX), TAMSULOSIN HYDROCHLORIDE (Dispensing Solutions), TAMSULOSIN HYDROCHLORIDE (Golden State Medical Supply), TAMSULOSIN HYDROCHLORIDE (H.J. Harkins Company), TAMSULOSIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TAMSULOSIN HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TAMSULOSIN HYDROCHLORIDE (Macleods Pharmaceuticals Limited), TAMSULOSIN HYDROCHLORIDE (Major Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (McKesson Corporation), TAMSULOSIN HYDROCHLORIDE (McKesson Corporation), TAMSULOSIN HYDROCHLORIDE (MedVantx), TAMSULOSIN HYDROCHLORIDE (Mylan Institutional), TAMSULOSIN HYDROCHLORIDE (Mylan Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (NCS HealthCare of KY), TAMSULOSIN HYDROCHLORIDE (NCS HealthCare of KY), TAMSULOSIN HYDROCHLORIDE (NCS HealthCare of KY), TAMSULOSIN HYDROCHLORIDE (NorthStar RxLLC), TAMSULOSIN HYDROCHLORIDE (Northwind Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (NuCare Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (PD-Rx Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (Par Pharmaceutical), TAMSULOSIN HYDROCHLORIDE (Physicians Total Care), TAMSULOSIN HYDROCHLORIDE (Preferred Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (Preferred Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (Proficient Rx LP), TAMSULOSIN HYDROCHLORIDE (Proficient Rx LP), TAMSULOSIN HYDROCHLORIDE (Proficient Rx LP), TAMSULOSIN HYDROCHLORIDE (REMEDYREPACK), TAMSULOSIN HYDROCHLORIDE (REMEDYREPACK), TAMSULOSIN HYDROCHLORIDE (REMEDYREPACK), TAMSULOSIN HYDROCHLORIDE (Rebel Distributors Corp), TAMSULOSIN HYDROCHLORIDE (RedPharm Drug), TAMSULOSIN HYDROCHLORIDE (RedPharm Drug), TAMSULOSIN HYDROCHLORIDE (RedPharm Drug), TAMSULOSIN HYDROCHLORIDE (Rising Health), TAMSULOSIN HYDROCHLORIDE (Sandoz), TAMSULOSIN HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), TAMSULOSIN HYDROCHLORIDE (State of Florida DOH Central Pharmacy), TAMSULOSIN HYDROCHLORIDE (Sun Pharmaceutical Industries Limited), TAMSULOSIN HYDROCHLORIDE (Synthon Pharmaceuticals), TAMSULOSIN HYDROCHLORIDE (Unit Dose Services), TAMSULOSIN HYDROCHLORIDE (Unit Dose Services), TAMSULOSIN HYDROCHLORIDE (WOCKHARDT LIMITED), TAMSULOSIN HYDROCHLORIDE (Wockhardt USA LLC.), TAMSULOSIN HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C20H28N2O5S. HCl
Exact mass
444.1486
Mol weight
444.9727
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01465  alpha-Adrenergic receptor antagonist
   DG01457  alpha1-Adrenergic receptor antagonist
Remark
Therapeutic category: 2590
ATC code: G04CA02
Chemical structure group: DG00490
Product (DG00490): D01024<JP/US>
Efficacy
Antidysuria, alpha1-Adrenergic receptor antagonist
Comment
Benign prostatic hyperplasia therapy agent
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04022  cGMP-PKG signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Interaction
Drug interaction
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
    G04CA Alpha-adrenoreceptor antagonists
     G04CA02 Tamsulosin
      D01024  Tamsulosin hydrochloride (JP17/USAN) <JP/US>
USP drug classification [BR:br08302]
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Tamsulosin
    D01024  Tamsulosin hydrochloride (JP17/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D01024  Tamsulosin hydrochloride (JP17/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D01024  Tamsulosin hydrochloride (JP17/USAN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01024  Tamsulosin hydrochloride
  D01024  Tamsulosin hydrochloride
Drug classes of therapeutic agents [br08360.html]
 Endocrine and hormonal agents
  D01024
BRITE hierarchy
Other DBs
CAS: 106463-17-6
PubChem: 7848087
ChEBI: 9399
ChEMBL: CHEMBL1200914
DrugBank: DB00706
LigandBox: D01024
NIKKAJI: J345.184D
KCF data Show

ATOM        29
            1   X   Cl   26.8800  -13.6500
            2   C8y C    20.0900  -15.1200
            3   C1b C    18.9000  -14.4200
            4   C1c C    17.7100  -15.1200
            5   N1b N    16.4500  -14.4200
            6   C1b C    15.2600  -15.1200
            7   C1b C    14.0700  -14.4200
            8   O2a O    12.8800  -15.1200
            9   C8y C    11.6200  -14.4200
            10  C8x C    10.4300  -15.1200
            11  C8x C    20.0900  -16.5200
            12  C8y C    21.3500  -17.2200
            13  C8y C    22.5400  -16.5200
            14  C8x C    22.5400  -15.1200
            15  C8x C    21.3500  -14.4200
            16  C1a C    17.7100  -16.5200
            17  C8y C    11.6200  -13.0200
            18  C8x C    10.4300  -12.3200
            19  C8x C     9.2400  -13.0200
            20  C8x C     9.2400  -14.4200
            21  O2a O    12.8800  -12.3200
            22  O2a O    23.8000  -17.2200
            23  C1a C    24.9900  -16.5200
            24  S4a S    21.3500  -18.6200
            25  O3c O    22.7500  -18.6200
            26  N1a N    21.3500  -20.0200
            27  O3c O    19.9500  -18.6200
            28  C1b C    14.0700  -13.0900
            29  C1a C    15.3300  -12.3900
BOND        29
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     7   8 1
            7     8   9 1
            8     9  10 1
            9     2  11 2
            10   11  12 1
            11   12  13 2
            12   13  14 1
            13   14  15 2
            14    2  15 1
            15    4  16 1 #Up
            16    9  17 2
            17   17  18 1
            18   18  19 2
            19   19  20 1
            20   20  10 2
            21   17  21 1
            22   13  22 1
            23   22  23 1
            24   12  24 1
            25   24  25 2
            26   24  26 1
            27   24  27 2
            28   21  28 1
            29   28  29 1

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