KEGG   DRUG: D01025Help
Entry
D01025                      Drug                                   

Name
Levobunolol hydrochloride (JAN/USP);
Betagan (TN)
Product
  Generic
Formula
C17H25NO3. HCl
Exact mass
327.1601
Mol weight
327.8462
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-adrenergic [beta-receptor] [DS:H00612]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04144  Endocytosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04540  Gap junction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED03 Levobunolol
      D01025  Levobunolol hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Levobunolol
    D01025  Levobunolol hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01025  Levobunolol hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Levobunolol
      D01025  Levobunolol hydrochloride (JAN/USP)
    beta2-adrenergic receptor
     Levobunolol
      D01025  Levobunolol hydrochloride (JAN/USP)
    beta3-adrenergic receptor
     Levobunolol
      D01025  Levobunolol hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
27912-14-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8y C    27.0575  -17.5142
            2   C8y C    25.8421  -16.8164
            3   C8y C    28.2670  -16.8164
            4   C1x C    27.0575  -18.9100
            5   C8x C    25.8421  -15.4150
            6   C5x C    24.6267  -17.5142
            7   C8x C    28.2670  -15.4150
            8   O2a O    29.4768  -17.5083
            9   C1x C    25.8477  -19.6194
            10  C8x C    27.0575  -14.7170
            11  C1x C    24.6323  -18.9157
            12  O5x O    23.4169  -16.8222
            13  C1b C    30.6804  -16.8164
            14  C1c C    31.8958  -17.5083
            15  C1b C    33.1056  -16.8107
            16  O1a O    31.8958  -18.9100
            17  N1b N    34.3211  -17.5083
            18  C1d C    35.5307  -16.8107
            19  C1a C    36.7558  -16.1039
            20  C1a C    36.2326  -18.0278
            21  C1a C    34.8341  -15.6029
            22  X   Cl   41.0330  -17.0548
BOND        22
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    6  12 2
            12    8  13 1
            13   13  14 1
            14   14  15 1
            15   14  16 1 #Down
            16   15  17 1
            17   17  18 1
            18    7  10 2
            19    9  11 1
            20   18  19 1
            21   18  20 1
            22   18  21 1

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