KEGG   DRUG: D01025Help
Entry
D01025                      Drug                                   

Name
Levobunolol hydrochloride (JAN/USP);
Betagan (TN)
Product
  Generic
Formula
C17H25NO3. HCl
Exact mass
327.1601
Mol weight
327.8462
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-adrenergic [beta-receptor] [DS:H00612]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04144  Endocytosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04540  Gap junction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED03 Levobunolol
      D01025  Levobunolol hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Levobunolol
    D01025  Levobunolol hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01025  Levobunolol hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Levobunolol
      D01025  Levobunolol hydrochloride (JAN/USP)
    beta2-adrenergic receptor
     Levobunolol
      D01025  Levobunolol hydrochloride (JAN/USP)
    beta3-adrenergic receptor
     Levobunolol
      D01025  Levobunolol hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
27912-14-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   X   Cl   27.6087  -32.8813
            2   C1d C    27.4400  -26.6700
            3   C1a C    28.6524  -27.3700
            4   N1b N    26.2276  -27.3700
            5   C1b C    25.0321  -26.6796
            6   C1c C    23.8447  -27.3651
            7   C1b C    22.6535  -26.6771
            8   O2a O    21.4640  -27.3638
            9   C1a C    27.4400  -25.2700
            10  C1a C    28.6524  -25.9700
            11  O1a O    23.8445  -28.7698
            12  C8y C    21.4640  -28.7638
            13  C8y C    20.2686  -29.4542
            14  C8y C    20.2689  -30.8542
            15  C8x C    21.4814  -31.5540
            16  C8x C    22.6768  -30.8636
            17  C8x C    22.6766  -29.4636
            18  C1x C    19.0560  -28.7545
            19  C1x C    17.8437  -29.4547
            20  C1x C    17.8440  -30.8547
            21  C5x C    19.0566  -31.5545
            22  O5x O    19.0570  -32.9699
BOND        22
            1     2   3 1
            2     2   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     7   8 1
            7     2   9 1
            8     2  10 1
            9     6  11 1 #Down
            10    8  12 1
            11   12  13 2
            12   13  14 1
            13   14  15 2
            14   15  16 1
            15   16  17 2
            16   12  17 1
            17   13  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   14  21 1
            22   21  22 2

» Japanese version   » Back

DBGET integrated database retrieval system