KEGG   DRUG: D01026Help
Entry
D01026                      Drug                                   

Name
Sotalol hydrochloride (JAN/USP);
Betapace (TN);
Sorine (TN)
Product
  Generic
SOTALOL HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), SOTALOL HYDROCHLORIDE (American Health Packaging), SOTALOL HYDROCHLORIDE (Apotex Corp.), SOTALOL HYDROCHLORIDE (Apotex Corp.), SOTALOL HYDROCHLORIDE (AvKARE), SOTALOL HYDROCHLORIDE (Bryant Ranch Prepack), SORINE (Cardinal Health), SOTALOL HYDROCHLORIDE (Eon Labs), SOTALOL HYDROCHLORIDE (Global Pharmaceuticals), SOTALOL HYDROCHLORIDE (Golden State Medical Supply), SOTALOL HYDROCHLORIDE (Golden State Medical Supply), SOTALOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), SOTALOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), SOTALOL HYDROCHLORIDE (Mylan Pharmaceuticals), SOTALOL HYDROCHLORIDE (NCS HealthCare of KY), SOTALOL HYDROCHLORIDE (PD-Rx Pharmaceuticals), SOTALOL HYDROCHLORIDE (Physicians Total Care), SOTALOL HYDROCHLORIDE (Qualitest Pharmaceuticals), SOTALOL HYDROCHLORIDE (Rebel Distributors Corp), SOTALOL HYDROCHLORIDE (Teva Pharmaceuticals USA), SORINE (Upsher-Smith Laboratories)
Formula
C12H20N2O3S. HCl
Exact mass
308.0961
Mol weight
308.8247
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-adrenergic [beta-receptor] [DS:H00293]
Remark
Therapeutic category: 
ATC code: 
Comment
Class III antiarrhythmic agent
Target
voltage-gated potassium channel (KCNH2) blocker [HSA:3757] [KO:K04905];
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes  
 
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Potassium channel blocking and opening drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D01026  Sotalol hydrochloride (JAN/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA07 Sotalol
      D01026  Sotalol hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Sotalol
    D01026  Sotalol hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor [HSA:153] [KO:K04141]
     Sotalol [ATC:C07AA07]
      D01026  Sotalol hydrochloride (JAN/USP)
    beta2-adrenergic receptor [HSA:154] [KO:K04142]
     Sotalol [ATC:C07AA07]
      D01026  Sotalol hydrochloride (JAN/USP)
 Ion channels
  Voltage-gated cation channels
   K+ channel, KCNH, Kv10-12.x (Ether-a-go-go)
    voltage-gated potassium channel (KCNH2) [HSA:3757] [KO:K04905]
     Sotalol [ATC:C07AA07]
      D01026  Sotalol hydrochloride (JAN/USP)
BRITE hierarchy
Other DBs
CAS: 
959-24-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C8y C    20.3000  -16.1700
            2   C1c C    21.4900  -16.8700
            3   C8x C    20.3000  -14.7700
            4   C8x C    19.0400  -16.8700
            5   C1b C    22.6800  -16.1700
            6   O1a O    21.4900  -18.2700
            7   C8x C    19.0400  -14.0700
            8   C8x C    17.8500  -16.1700
            9   N1b N    23.9400  -16.8700
            10  C8y C    17.8500  -14.7700
            11  C1c C    25.1300  -16.1700
            12  N1b N    16.6600  -14.0700
            13  C1a C    26.3900  -16.8700
            14  C1a C    25.1300  -14.7700
            15  S4a S    15.4000  -14.7700
            16  C1a C    14.2100  -14.0700
            17  O3c O    16.6600  -15.4700
            18  O3c O    14.3500  -15.4700
            19  X   Cl   30.0300  -16.9400
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1
            11   10  12 1
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15   15  16 1
            16   15  17 2
            17   15  18 2
            18    8  10 2

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