KEGG   DRUG: Sotalol hydrochlorideHelp
Entry
D01026                      Drug                                   

Name
Sotalol hydrochloride (JAN/USP);
Betapace (TN);
Sorine (TN)
Product
  Generic
SOTALOL HYDROCHLORIDE (A-S Medication Solutions), SOTALOL HYDROCHLORIDE (A-S Medication Solutions), SOTALOL HYDROCHLORIDE (Aidarex Pharmaceuticals LLC), SOTALOL HYDROCHLORIDE (American Health Packaging), SOTALOL HYDROCHLORIDE (Apotex Corp.), SOTALOL HYDROCHLORIDE (Apotex Corp.), SOTALOL HYDROCHLORIDE (AvKARE), SOTALOL HYDROCHLORIDE (Bryant Ranch Prepack), SOTALOL HYDROCHLORIDE (Bryant Ranch Prepack), SORINE (Cardinal Health), SOTALOL HYDROCHLORIDE (Carilion Materials Management), SOTALOL HYDROCHLORIDE (Eon Labs), SOTALOL HYDROCHLORIDE (Epic Pharma), SOTALOL HYDROCHLORIDE (Golden State Medical Supply), SOTALOL HYDROCHLORIDE (Golden State Medical Supply), SOTALOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), SOTALOL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), SOTALOL HYDROCHLORIDE (Mylan Pharmaceuticals), SOTALOL HYDROCHLORIDE (NCS HealthCare of KY), SOTALOL HYDROCHLORIDE (NCS HealthCare of KY), SOTALOL HYDROCHLORIDE (PD-Rx Pharmaceuticals), SOTALOL HYDROCHLORIDE (Physicians Total Care), SOTALOL HYDROCHLORIDE (Proficient Rx LP), SOTALOL HYDROCHLORIDE (Qualitest Pharmaceuticals), SOTALOL HYDROCHLORIDE (Rebel Distributors Corp), SOTALOL HYDROCHLORIDE (Teva Pharmaceuticals USA), SORINE (Upsher-Smith Laboratories)
Formula
C12H20N2O3S. HCl
Exact mass
308.0961
Mol weight
308.8247
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antiarrhythmic, beta-Adrenergic receptor antagonist, Potassium channel blocker
Target
KCNH2 [HSA:3757] [KO:K04905];
ADRB1 [HSA:153] [KO:K04141];
ADRB2 [HSA:154] [KO:K04142]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Potassium channel blocking and opening drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA07 Sotalol
      D01026  Sotalol hydrochloride (JAN/USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Sotalol
    D01026  Sotalol hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D01026  Sotalol hydrochloride (JAN/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Sotalol
      D01026  Sotalol hydrochloride (JAN/USP)
    beta2-adrenergic receptor
     Sotalol
      D01026  Sotalol hydrochloride (JAN/USP)
 Ion channels
  Voltage-gated cation channels
   K+ channel, KCNH, Kv10-12.x (Ether-a-go-go)
    voltage-gated potassium channel (KCNH2)
     Sotalol
      D01026  Sotalol hydrochloride (JAN/USP)
Cardiovascular agents [br08364.html]
 Antiarrhythmics
  D01026
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D01026
BRITE hierarchy
Other DBs
CAS: 
959-24-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C8y C    20.3000  -16.1700
            2   C1c C    21.4900  -16.8700
            3   C8x C    20.3000  -14.7700
            4   C8x C    19.0400  -16.8700
            5   C1b C    22.6800  -16.1700
            6   O1a O    21.4900  -18.2700
            7   C8x C    19.0400  -14.0700
            8   C8x C    17.8500  -16.1700
            9   N1b N    23.9400  -16.8700
            10  C8y C    17.8500  -14.7700
            11  C1c C    25.1300  -16.1700
            12  N1b N    16.6600  -14.0700
            13  C1a C    26.3900  -16.8700
            14  C1a C    25.1300  -14.7700
            15  S4a S    15.4000  -14.7700
            16  C1a C    14.2100  -14.0700
            17  O3c O    16.6600  -15.4700
            18  O3c O    14.3500  -15.4700
            19  X   Cl   30.0300  -16.9400
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1
            11   10  12 1
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15   15  16 1
            16   15  17 2
            17   15  18 2
            18    8  10 2

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