KEGG   DRUG: Tirofiban hydrochlorideHelp
Entry
D01029                      Drug                                   

Name
Tirofiban hydrochloride (USAN);
Tirofiban hydrochloride hydrate;
Aggrastat (TN)
Product
Formula
C22H36N2O5S. HCl. H2O
Exact mass
494.2217
Mol weight
495.0729
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01712  Antiplatelet agent
  DG01712  Antiplatelet agent
 DG01811  Fibrinogen receptor antagonist
Remark
ATC code: 
Chemical group: 
Activity
Platelet aggregation inhibitor, Glycoprotein IIb/IIIa receptor antagonist
Comment
Treatment of unstable angina
Indication: Acute coronary syndrome
Target
ITGA2B/ITGB3 [HSA:3674 3690] [KO:K06476 K06493]
  Pathway
Focal adhesion
ECM-receptor interaction
Interaction
Drug interaction
Structure map
Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC17 Tirofiban
      D01029  Tirofiban hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 Others
  Cell adhesion molecules (CAMs)
   glycoprotein alpha IIb/beta3 (GPIIb/IIIa) receptor
    Tirofiban
     D01029  Tirofiban hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
150915-40-5
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        32
            1   C8y C    20.3341  -17.4804
            2   C1b C    19.1266  -16.7827
            3   C8x C    20.3273  -18.8690
            4   C8x C    21.5348  -16.7759
            5   C1c C    17.9257  -17.4804
            6   C8x C    21.5348  -19.5666
            7   C8x C    22.7357  -17.4737
            8   N1b N    17.9257  -18.8690
            9   C6a C    16.7116  -16.7827
            10  C8y C    22.7357  -18.8690
            11  S4a S    16.7853  -19.6405
            12  O6a O    15.5041  -17.4804
            13  O6a O    16.7116  -15.3873
            14  O2a O    23.9430  -19.5666
            15  C1b C    15.5041  -18.8690
            16  O3c O    17.9794  -20.5125
            17  O3c O    15.6517  -20.5058
            18  C1b C    25.1573  -18.8690
            19  C1b C    14.3034  -19.5734
            20  C1b C    26.3580  -19.5666
            21  C1b C    13.0960  -18.8690
            22  C1b C    27.5655  -18.8690
            23  C1a C    11.8884  -19.5734
            24  C1b C    28.7731  -19.5666
            25  C1y C    29.9738  -18.8690
            26  C1x C    31.1746  -19.5666
            27  C1x C    29.9671  -17.4737
            28  C1x C    32.3821  -18.8690
            29  C1x C    31.1746  -16.7759
            30  N1x N    32.3821  -17.4737
            31  X   Cl   28.6047  -21.4468
            32  O0  O    32.4098  -21.3266
BOND        31
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 2
            7     5   8 1 #Down
            8     5   9 1
            9     6  10 2
            10    8  11 1
            11    9  12 1
            12    9  13 2
            13   10  14 1
            14   11  15 1
            15   11  16 2
            16   11  17 2
            17   14  18 1
            18   15  19 1
            19   18  20 1
            20   19  21 1
            21   20  22 1
            22   21  23 1
            23   22  24 1
            24   24  25 1
            25   25  26 1
            26   25  27 1
            27   26  28 1
            28   27  29 1
            29   28  30 1
            30    7  10 1
            31   29  30 1

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