KEGG   DRUG: D01051Help
Entry
D01051                      Drug                                   

Name
Spiperone (JAN/USAN);
Spiropitan (TN)
Formula
C23H26FN3O2
Exact mass
395.2009
Mol weight
395.4698
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antipsychotic
Remark
Therapeutic category: 
Comment
Butyrophenone derivatives
Target
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145];
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
5-HT1A-receptor antagonist [HSA:3350] [KO:K04153];
5-HT7-receptor antagonist [HSA:3363] [KO:K04163]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction  
 
Interaction
Drug interaction
Structure map
Butyrophenones
Dopamine receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01051  Spiperone (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Spiperone
      D01051  Spiperone (JAN/USAN)
   Serotonin
    5-HT1A-receptor
     Spiperone
      D01051  Spiperone (JAN/USAN)
    5-HT2A-receptor
     Spiperone
      D01051  Spiperone (JAN/USAN)
    5-HT7-receptor
     Spiperone
      D01051  Spiperone (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
749-02-0
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   N1y N    26.8289  -17.2797
            2   N1x N    30.7754  -14.0613
            3   C1x C    31.5060  -15.2542
            4   N1y N    30.5878  -16.3243
            5   C1z C    29.2967  -15.7828
            6   C5x C    29.3413  -14.3917
            7   C1x C    29.3410  -17.2043
            8   C1x C    28.0502  -15.1344
            9   C1x C    28.1362  -17.9562
            10  C1x C    26.7826  -15.8742
            11  C1b C    25.6795  -17.9800
            12  C1b C    24.4742  -17.2770
            13  C1b C    23.2763  -17.9743
            14  C5a C    22.0770  -17.2652
            15  O5a O    22.0581  -15.8696
            16  C8y C    20.8608  -17.9699
            17  C8x C    20.8640  -19.3738
            18  C8x C    19.6478  -20.0787
            19  C8y C    18.4295  -19.3777
            20  C8x C    18.4272  -17.9721
            21  C8x C    19.6434  -17.2674
            22  X   F    17.2132  -20.0824
            23  C8y C    30.9070  -17.6744
            24  C8x C    29.9061  -18.6173
            25  C8x C    30.2294  -19.9858
            26  C8x C    31.5762  -20.3901
            27  C8x C    32.5771  -19.4472
            28  C8x C    32.2538  -18.0787
            29  O5x O    28.2672  -13.5087
BOND        32
            1     7   9 1
            2     8  10 1
            3     9   1 1
            4    10   1 1
            5     2   3 1
            6     3   4 1
            7     4   5 1
            8     5   6 1
            9     6   2 1
            10    5   7 1
            11    5   8 1
            12   14  16 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   21  16 2
            23   19  22 1
            24   11   1 1
            25    4  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   23  28 1
            32    6  29 2

» Japanese version   » Back

DBGET integrated database retrieval system