KEGG   DRUG: D01063Help
Entry
D01063                      Drug                                   

Name
Gentamicin sulfate (JP16/USP);
Garamycin (TN);
Gentacin (TN)
Product
  Generic
GENTAMICIN (Cardinal Health), GENTAMICIN (Fresenius Kabi USA), GENTAMICIN (Fresenius Kabi USA), GENTAMICIN (Fresenius Kabi USA), GENTAMICIN SULFATE (A-S Medication Solutions LLC), GENTAK (A-S Medication Solutions LLC), GENTAMICIN SULFATE (A-S Medication Solutions LLC), GENTAMICIN (APP Pharmaceuticals), GENTAMICIN SULFATE (Aidarex Pharmaceuticals LLC), GENTAMICIN SULFATE (Akorn), GENTAK (Akorn), GENTAMICIN SULFATE (Akorn), GENTAK (Akorn), GENTAMICIN SULFATE (Bausch & Lomb Incorporated), GENTAMICIN SULFATE IN SODIUM CHLORIDE (Baxter Healthcare Corporation), GENTAMICIN (Cardinal Health), GENTAMICIN SULFATE (Cardinal Health), GENTAMICIN (Cardinal Health), GENTAMICIN SULFATE (Clinical Solutions Wholesale), GENTAMICIN SULFATE (Dispensing Solutions), GENTAMICIN SULFATE (E. FOUGERA &), GENTAMICIN SULFATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), GENTAMICIN SULFATE (Fera Pharmaceuticals), GARAMYCIN (Fera Pharmaceuticals), GARAMYCIN (Fera Pharmaceuticals), GENTAMICIN (Fresenius Kabi USA), GENTAMICIN (Fresenius Kabi USA), GENTAMICIN (Fresenius Kabi USA), GENTAMICIN SULFATE (General Injectables & Vaccines), GENTAMICIN (General Injectables & Vaccines), GENTAMICIN SULFATE IN SODIUM CHLORIDE (Hospira), GENTAMICIN SULFATE (Hospira), GENTAMICIN SULFATE (Hospira), GENTAMICIN SULFATE (Hospira), GENTAMICIN SULFATE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), GENTAK (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), GENTAMICIN SULFATE (Lake Erie Medical & Surgical Suppy DBA Quality Care Products LLC), GENTAMICIN SULFATE (Pacific Pharma), GENTAMICIN SULFATE (Paddock Laboratories), GARAMYCIN GENTAMICIN SULFATE (Paddock Laboratories), GENTAMICIN SULFATE (Perrigo New York), GENTAMICIN SULFATE (Perrigo New York), GENTAMICIN SULFATE (Physicians Total Care), GENTAMICIN SULFATE (Physicians Total Care), GENTAMICIN SULFATE (Physicians Total Care), GENTAMICIN SULFATE (Physicians Total Care), GENTAMICIN SULFATE (Preferred Pharmaceuticals), GENTAMICIN SULFATE (Preferred Pharmaceuticals), GENTAK (Preferred Pharmaceuticals), GENTAK (REMEDYREPACK), GENTAMICIN SULFATE (REMEDYREPACK), GENTAMICIN SULFATE (REMEDYREPACK), GENTAMICIN SULFATE (Rebel Distributors Corp), GENTAMICIN SULFATE (STAT RX USA LLC), GENTAMICIN SULFATE (Sandoz), GENTAMICIN SULFATE (Unit Dose Services)
Formula
C19H37N5O7(R1)(R2). H2SO4
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Micromonospora purpurea [TAX:1877]
Activity
Antibacterial
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Mixture of sulfates salt of Gentamicin C [CPD:C01918]
Gentamicin C1A (R1 = -H, R2 = -H) [CPD:C00908]
Gentamicin C1 (R1 = -CH3, R2 = -CH3) [CPD:C07656]
Gentamicin C2 (R1 = -CH3, R2 = -H) [CPD:C02033]
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX07 Gentamicin
      D01063  Gentamicin sulfate (JP16/USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01G AMINOGLYCOSIDE ANTIBACTERIALS
    J01GB Other aminoglycosides
     J01GB03 Gentamicin
      D01063  Gentamicin sulfate (JP16/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA11 Gentamicin
      D01063  Gentamicin sulfate (JP16/USP)
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA14 Gentamicin
      D01063  Gentamicin sulfate (JP16/USP)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA06 Gentamicin
      D01063  Gentamicin sulfate (JP16/USP)
USP drug classification [BR:br08302]
 Antibacterials
  Aminoglycosides
   Gentamicin
    D01063  Gentamicin sulfate (JP16/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1317  Ophthalmic antibiotics
     D01063  Gentamicin sulfate (JP16/USP)
 2  Agents affecting individual organs
  26  Epidermides
   263  Suppurative dermatosis agents
    2634  Antibiotics for external use
     D01063  Gentamicin sulfate (JP16/USP)
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   613  Acting mainly on gram-positive and gram-negative bacteria
    6134  Amino sugars
     D01063  Gentamicin sulfate (JP16/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Aminoglycosides
     Gentamicin
      D01063  Gentamicin sulfate (JP16/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01063  Gentamicin sulfate
  D01063  Gentamicin sulfate ophthalmic solution
BRITE hierarchy
Other DBs
CAS: 
1405-41-0
PubChem: 
DrugBank: 
NIKKAJI: 
KCF data Show

ATOM        38
            1   S4a S    53.5166  -22.8214
            2   O1d O    53.5166  -21.4177
            3   O1d O    53.5166  -24.1551
            4   O1d O    54.9203  -22.8214
            5   O1d O    52.1830  -22.8214
            6   C1x C    38.9466  -19.9619
            7   C1z C    38.9466  -21.3632
            8   C1y C    40.1600  -22.0639
            9   C1y C    41.3736  -21.3632
            10  C1y C    41.3736  -19.9619
            11  O2x O    40.1600  -19.2614
            12  O2a O    42.6058  -19.2504
            13  C1y C    43.8193  -18.5497
            14  C1y C    45.0612  -19.2669
            15  C1x C    46.2748  -18.5664
            16  C1y C    46.2750  -17.1651
            17  C1y C    45.0331  -16.4480
            18  C1y C    43.8195  -17.1484
            19  O1a O    42.6058  -22.0749
            20  C1a C    38.5840  -22.7167
            21  O1a O    37.5453  -21.3632
            22  N1b N    40.1600  -23.4649
            23  C1a C    38.9298  -24.1754
            24  N1a N    45.0610  -20.6625
            25  O1a O    42.6345  -16.4639
            26  N1a N    47.5120  -16.4509
            27  O2a O    45.0333  -15.0576
            28  C1y C    46.2535  -14.3534
            29  O2x O    47.4531  -15.0464
            30  C1y C    48.6668  -14.3461
            31  C1x C    48.6671  -12.9449
            32  C1x C    47.4675  -12.2519
            33  C1y C    46.2538  -12.9521
            34  C1c C    49.8987  -15.0577
            35  Z   R#   51.0955  -14.3670
            36  N1b N    49.8984  -16.4586
            37  Z   R#   51.0952  -17.1500
            38  N1a N    45.0266  -12.2431
BOND        39
            1     1   2 2
            2     1   3 2
            3     1   4 1
            4     1   5 1
            5     6   7 1
            6     7   8 1
            7     8   9 1
            8     9  10 1
            9    10  11 1
            10    6  11 1
            11   10  12 1 #Down
            12   13  12 1 #Down
            13   13  14 1
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   13  18 1
            19    9  19 1 #Down
            20    7  20 1 #Down
            21    7  21 1 #Up
            22    8  22 1 #Up
            23   22  23 1
            24   14  24 1 #Up
            25   18  25 1 #Up
            26   16  26 1 #Up
            27   17  27 1 #Down
            28   28  27 1 #Down
            29   28  29 1
            30   29  30 1
            31   30  31 1
            32   31  32 1
            33   32  33 1
            34   28  33 1
            35   30  34 1
            36   34  35 1 #Up
            37   34  36 1
            38   36  37 1
            39   33  38 1 #Down

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