KEGG   DRUG: D01069Help
Entry
D01069                      Drug                                   

Name
Cilazapril hydrate (JP16);
Cilazapril (USAN);
Inhibace (TN)
Formula
C22H31N3O5. H2O
Exact mass
435.2369
Mol weight
435.5139
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
prodrug, active substance: Cilazaprilat [CPD:C17309]
Target
angiotensin-converting enzyme (ACE) inhibitor [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system  
 
Interaction
Drug interaction
Structure map
Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA08 Cilazapril
      D01069  Cilazapril hydrate (JP16); Cilazapril (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2144  Angiotensin converting enzyme inhibitors
     D01069  Cilazapril hydrate (JP16); Cilazapril (USAN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   angiotensin-converting enzyme (ACE)
    Cilazapril
     D01069  Cilazapril (USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01069  Cilazapril hydrate
  D01069  Cilazapril tablets
BRITE hierarchy
Other DBs
CAS: 
92077-78-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        31
            1   C1x C    19.1800  -19.8800
            2   N1y N    18.3400  -18.7600
            3   N1y N    18.6900  -17.4300
            4   C5x C    19.9500  -16.8700
            5   C1x C    20.5800  -19.8800
            6   C1y C    21.2100  -17.5000
            7   C1x C    21.4900  -18.8300
            8   C1y C    17.6400  -16.4500
            9   C1x C    16.3100  -16.8700
            10  C1x C    15.9600  -18.2000
            11  C1x C    17.0100  -19.1800
            12  C6a C    17.9490  -15.0845
            13  O6a O    19.2686  -14.6742
            14  O6a O    16.8878  -14.1042
            15  O5x O    19.9818  -15.4704
            16  C7a C    23.9149  -18.8300
            17  C1c C    23.9149  -17.4300
            18  N1b N    22.7024  -16.7300
            19  C1b C    25.1460  -16.7190
            20  C1b C    26.3512  -17.4147
            21  C8y C    27.5335  -16.7319
            22  O7a O    25.1460  -19.5410
            23  O6a O    22.7214  -19.5192
            24  C1b C    26.3512  -18.8453
            25  C1a C    27.5335  -19.5281
            26  C8x C    28.7275  -17.4212
            27  C8x C    29.9399  -16.7212
            28  C8x C    29.9399  -15.3212
            29  C8x C    28.7460  -14.6319
            30  C8x C    27.5335  -15.3319
            31  O0  O    32.2000  -18.4800
BOND        32
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12    2  11 1
            13    8  12 1 #Up
            14   12  13 2
            15   12  14 1
            16    4  15 2
            17   17  16 1 #Up
            18   17  18 1
            19    6  18 1 #Up
            20   17  19 1
            21   19  20 1
            22   20  21 1
            23   16  22 1
            24   16  23 2
            25   22  24 1
            26   24  25 1
            27   21  26 2
            28   26  27 1
            29   27  28 2
            30   28  29 1
            31   29  30 2
            32   21  30 1

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