KEGG   DRUG: Chloramphenicol palmitateHelp
Entry
D01072                      Drug                                   

Name
Chloramphenicol palmitate (JP17/USP);
Chloromycetin palmitate (TN)
Formula
C27H42Cl2N2O6
Exact mass
560.242
Mol weight
561.5382
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01576  Amphenicol type antibacterial
Cyp substrate
 DG01639  CYP2C19 substrate
Cyp inhibitor
 DG01522  CYP3A4 inhibitor
 DG01915  CYP3A5 ihibitor
Remark
Activity
Antibacterial, Antirickettsial, Protein biosynthesis inhibitor
Comment
Amphenicol derivative
Target
50S ribosomal subunit
  Pathway
Ribosome
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
CYP inhibition: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX02 Chloramphenicol
      D01072  Chloramphenicol palmitate (JP17/USP)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF03 Chloramphenicol
      D01072  Chloramphenicol palmitate (JP17/USP)
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA05 Chloramphenicol
      D01072  Chloramphenicol palmitate (JP17/USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01B AMPHENICOLS
    J01BA Amphenicols
     J01BA01 Chloramphenicol
      D01072  Chloramphenicol palmitate (JP17/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA01 Chloramphenicol
      D01072  Chloramphenicol palmitate (JP17/USP)
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA01 Chloramphenicol
      D01072  Chloramphenicol palmitate (JP17/USP)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA08 Chloramphenicol
      D01072  Chloramphenicol palmitate (JP17/USP)
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Chloramphenicol
    D01072  Chloramphenicol palmitate (JP17/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   50S subunit inhibitor
    Amphenicols
     Chloramphenicol
      D01072  Chloramphenicol palmitate (JP17/USP)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C19
   Chloramphenicol
    D01072  Chloramphenicol palmitate (JP17/USP)
  CYP3A4
   Chloramphenicol
    D01072  Chloramphenicol palmitate (JP17/USP)
  CYP3A5
   Chloramphenicol
    D01072  Chloramphenicol palmitate (JP17/USP)
  CYP3A7
   Chloramphenicol
    D01072  Chloramphenicol palmitate (JP17/USP)
 CYP substrates
  CYP2C19
   Chloramphenicol
    D01072  Chloramphenicol palmitate (JP17/USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01072  Chloramphenicol palmitate
BRITE hierarchy
Other DBs
CAS: 
530-43-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        37
            1   C8y C    12.6215  -14.5428
            2   C1c C    12.6208  -15.9456
            3   C8x C    11.4147  -13.8255
            4   C8x C    13.8536  -13.8269
            5   C1c C    13.8347  -16.6514
            6   O1a O    11.4004  -16.6444
            7   C8x C    11.4154  -12.4107
            8   C8x C    13.8543  -12.4121
            9   N1b N    15.0422  -15.9529
            10  C1b C    13.8209  -18.0544
            11  C8y C    12.6230  -11.7193
            12  C5a C    16.2559  -16.6587
            13  O7a O    12.6075  -18.7528
            14  N2b N    12.6239  -10.3093 #+
            15  C1c C    17.4694  -15.9671
            16  O5a O    16.2552  -18.0617
            17  O3a O    11.4171   -9.6106
            18  O3a O    13.8327   -9.6003 #-
            19  X   Cl   18.6831  -16.6658
            20  X   Cl   17.4760  -14.5572
            21  C7a C    12.6011  -20.1540
            22  O6a O    11.3808  -20.8454
            23  C1b C    13.8080  -20.8565
            24  C1b C    15.0285  -20.1651
            25  C1b C    16.2354  -20.8746
            26  C1b C    17.4470  -20.1759
            27  C1b C    18.6497  -20.8800
            28  C1b C    19.8671  -20.1842
            29  C1b C    21.0699  -20.8885
            30  C1b C    22.2733  -20.1926
            31  C1b C    23.4760  -20.8898
            32  C1b C    24.6725  -20.1940
            33  C1b C    25.8822  -20.8912
            34  C1b C    27.0787  -20.1953
            35  C1b C    28.2883  -20.8925
            36  C1b C    29.4848  -20.1967
            37  C1a C    30.6810  -20.8929
BOND        37
            1    15  19 1
            2    15  20 1
            3     8  11 1
            4    13  21 1
            5     1   2 1
            6    21  22 2
            7     1   3 2
            8    21  23 1
            9     1   4 1
            10   23  24 1
            11    2   5 1
            12   24  25 1
            13    2   6 1 #Down
            14   25  26 1
            15    3   7 1
            16   26  27 1
            17    4   8 2
            18   27  28 1
            19    5   9 1
            20   28  29 1
            21    5  10 1
            22   29  30 1
            23    7  11 2
            24   30  31 1
            25    9  12 1
            26   31  32 1
            27   10  13 1
            28   32  33 1
            29   11  14 1
            30   33  34 1
            31   12  15 1
            32   34  35 1
            33   12  16 2
            34   35  36 1
            35   14  17 2
            36   36  37 1
            37   14  18 1

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