KEGG   DRUG: D01072Help
Entry
D01072                      Drug                                   

Name
Chloramphenicol palmitate (JP16/USP);
Chloromycetin palmitate (TN)
Formula
C27H42Cl2N2O6
Exact mass
560.242
Mol weight
561.5382
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial;
Antirickettsial
Remark
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
CYP inhibition: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX02 Chloramphenicol
      D01072  Chloramphenicol palmitate (JP16/USP)
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF03 Chloramphenicol
      D01072  Chloramphenicol palmitate (JP16/USP)
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA05 Chloramphenicol
      D01072  Chloramphenicol palmitate (JP16/USP)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01B AMPHENICOLS
    J01BA Amphenicols
     J01BA01 Chloramphenicol
      D01072  Chloramphenicol palmitate (JP16/USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA01 Chloramphenicol
      D01072  Chloramphenicol palmitate (JP16/USP)
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA01 Chloramphenicol
      D01072  Chloramphenicol palmitate (JP16/USP)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA08 Chloramphenicol
      D01072  Chloramphenicol palmitate (JP16/USP)
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Chloramphenicol
    D01072  Chloramphenicol palmitate (JP16/USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor [KO:K01980]
    Amphenicols
     Chloramphenicol [ATC:D06AX02 D10AF03 G01AA05 J01BA01 S01AA01 S02AA01 S03AA08]
      D01072  Chloramphenicol palmitate (JP16/USP)
BRITE hierarchy
Other DBs
CAS: 
530-43-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        37
            1   C8y C    12.6215  -14.5428
            2   C1c C    12.6208  -15.9456
            3   C8x C    11.4147  -13.8255
            4   C8x C    13.8536  -13.8269
            5   C1c C    13.8347  -16.6514
            6   O1a O    11.4004  -16.6444
            7   C8x C    11.4154  -12.4107
            8   C8x C    13.8543  -12.4121
            9   N1b N    15.0422  -15.9529
            10  C1b C    13.8209  -18.0544
            11  C8y C    12.6230  -11.7193
            12  C5a C    16.2559  -16.6587
            13  O7a O    12.6075  -18.7528
            14  N2b N    12.6239  -10.3093 #+
            15  C1c C    17.4694  -15.9671
            16  O5a O    16.2552  -18.0617
            17  O3a O    11.4171   -9.6106
            18  O3a O    13.8327   -9.6003 #-
            19  X   Cl   18.6831  -16.6658
            20  X   Cl   17.4760  -14.5572
            21  C7a C    12.6011  -20.1540
            22  O6a O    11.3808  -20.8454
            23  C1b C    13.8080  -20.8565
            24  C1b C    15.0285  -20.1651
            25  C1b C    16.2354  -20.8746
            26  C1b C    17.4470  -20.1759
            27  C1b C    18.6497  -20.8800
            28  C1b C    19.8671  -20.1842
            29  C1b C    21.0699  -20.8885
            30  C1b C    22.2733  -20.1926
            31  C1b C    23.4760  -20.8898
            32  C1b C    24.6725  -20.1940
            33  C1b C    25.8822  -20.8912
            34  C1b C    27.0787  -20.1953
            35  C1b C    28.2883  -20.8925
            36  C1b C    29.4848  -20.1967
            37  C1a C    30.6810  -20.8929
BOND        37
            1    15  19 1
            2    15  20 1
            3     8  11 1
            4    13  21 1
            5     1   2 1
            6    21  22 2
            7     1   3 2
            8    21  23 1
            9     1   4 1
            10   23  24 1
            11    2   5 1
            12   24  25 1
            13    2   6 1 #Down
            14   25  26 1
            15    3   7 1
            16   26  27 1
            17    4   8 2
            18   27  28 1
            19    5   9 1
            20   28  29 1
            21    5  10 1
            22   29  30 1
            23    7  11 2
            24   30  31 1
            25    9  12 1
            26   31  32 1
            27   10  13 1
            28   32  33 1
            29   11  14 1
            30   33  34 1
            31   12  15 1
            32   34  35 1
            33   12  16 2
            34   35  36 1
            35   14  17 2
            36   36  37 1
            37   14  18 1

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