KEGG   DRUG: D01077Help
Entry
D01077                      Drug                                   

Name
Atropine methonitrate (JAN/INN);
Methylatropine nitrate (USAN);
Ekomine (TN)
Formula
C18H26NO3. NO3
Exact mass
366.1791
Mol weight
366.4088
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anticholinergic
Remark
ATC code: 
Target
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
   A03B BELLADONNA AND DERIVATIVES, PLAIN
    A03BB Belladonna alkaloids, semisynthetic, quaternary ammonium compounds
     A03BB02 Methylatropine
      D01077  Atropine methonitrate (JAN/INN); Methylatropine nitrate (USAN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Antispasmodics, Gastrointestinal
   Atropine
    D01077  Atropine methonitrate (JAN/INN); Methylatropine nitrate (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
     Methylatropine [ATC:A03BB02]
      D01077  Atropine methonitrate (JAN/INN); Methylatropine nitrate (USAN)
BRITE hierarchy
Other DBs
CAS: 
52-88-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   N2b N    32.1276  -18.8381 #+
            2   O3a O    32.1276  -17.7275
            3   O3a O    30.8418  -19.6973 #-
            4   O3a O    33.4778  -19.5804 #-
            5   C1x C    18.2238  -19.1608
            6   C1x C    18.5519  -17.9891
            7   C1y C    19.3955  -18.8796
            8   C1y C    19.7236  -17.7079
            9   N2y N    18.4582  -16.3956 #+
            10  C1x C    21.2702  -18.8796
            11  C1x C    20.9890  -17.7079
            12  C1y C    22.3013  -19.4420
            13  O7a O    23.3793  -20.3325
            14  C7a C    24.5979  -20.3325
            15  C1c C    25.2072  -19.2545
            16  O6a O    25.2072  -21.4573
            17  C8y C    26.4258  -19.2545
            18  C1b C    24.5979  -18.2234
            19  O1a O    25.2072  -17.1455
            20  C8x C    27.1320  -20.4782
            21  C8x C    28.5320  -20.4785
            22  C8x C    29.2322  -19.2662
            23  C8x C    28.5261  -18.0425
            24  C8x C    27.1261  -18.0422
            25  C1a C    17.7091  -15.2114
            26  C1a C    17.2289  -17.0083
BOND        27
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     5   6 1
            5     5   7 1
            6     6   8 1
            7     7   9 1
            8     7  10 1
            9     8  11 1
            10   10  12 1
            11   12  13 1 #Down
            12   13  14 1
            13   14  15 1
            14   14  16 2
            15   15  17 1
            16   15  18 1
            17   18  19 1
            18    8   9 1
            19   11  12 1
            20   17  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   17  24 1
            26    9  25 1
            27    9  26 1

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