| Entry |
|
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| Name |
Telithromycin (JAN/USAN/INN);
TEL;
Ketek (TN)
|
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| Product |
|
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| Formula |
C43H65N5O10
|
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| Exact mass |
811.4731
|
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| Mol weight |
812.0037
|
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| Structure |
     |
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| Activity |
Antimicrobial [via inhibition of bacterial protein synthesis]
|
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| Remark |
|
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| Comment |
ketolide antibiotic
|
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| Target |
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO: K01980] |
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| Pathway |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP2D6 [HSA: 1565]
|
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| Interaction |
CYP inhibition: CYP3A [KO: K07424], CYP2D6 [HSA: 1565]
 |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
J01FA Macrolides
J01FA15 Telithromycin
D01078 Telithromycin (JAN/USAN/INN)
USP drug classification [BR:br08302]
Antibacterials
Macrolides
Telithromycin
D01078 Telithromycin (JAN/USAN/INN)
Antiinfectives [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
23S rRNA of 50S ribosomal subunit inhibitor [KO:K01980]
Ketolides
Telithromycin [ATC:J01FA15]
D01078 Telithromycin (JAN/USAN/INN)
 |
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| Other DBs |
CAS: 191114-48-4 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 58
1 C8y C 16.0034 -17.8817
2 N5x N 16.3533 -19.2523
3 C8x C 17.6981 -19.2535
4 N4y N 18.1764 -17.9968
5 C8x C 17.1318 -17.1449
6 C8x C 12.5082 -15.8594
7 N5x N 12.5082 -17.2079
8 C8x C 13.6908 -17.8820
9 C8y C 14.8455 -17.2079
10 C8x C 14.8455 -15.8594
11 C8x C 13.6908 -15.1920
12 C1y C 29.6485 -20.9856
13 C5x C 28.4682 -21.6682
14 C1y C 29.6485 -19.6264
15 C1y C 28.4682 -23.0273
16 C1z C 28.4682 -18.9505
17 C7x C 27.3081 -23.7099
18 C1x C 28.4682 -17.5858
19 O7x O 26.1223 -23.0273
20 C1y C 27.3081 -16.9088
21 C1y C 26.1223 -21.6682
22 C5x C 26.1223 -17.5858
23 C1y C 26.1223 -18.9505
24 O5x O 27.3063 -20.9885
25 C1a C 29.6485 -23.7063
26 O6a O 27.3094 -25.0710
27 C1z C 24.9444 -20.9863
28 C1y C 24.9417 -19.6264
29 N1y N 22.9050 -19.2146
30 C7x C 22.1094 -20.3139
31 O7x O 22.9095 -21.4031
32 C1a C 24.5884 -22.2876
33 C1a C 24.9325 -18.2767
34 O5x O 24.9403 -16.9017
35 C1a C 27.3094 -15.5506
36 O2a O 29.1429 -17.4649
37 C1a C 29.9864 -18.3324
38 O2a O 31.3401 -19.4683
39 C1y C 32.8538 -20.0175
40 C1y C 34.0510 -19.3434
41 O2x O 32.8315 -21.3832
42 C1y C 35.2161 -20.0312
43 O1a O 34.0645 -17.9885
44 C1y C 34.0225 -22.0881
45 C1x C 35.2144 -21.4071
46 N1c N 36.3976 -19.3602
47 C1a C 34.0171 -23.4462
48 C1a C 37.5703 -20.0490
49 C1a C 36.4035 -18.0030
50 C1a C 30.8376 -21.6651
51 C1b C 22.8961 -17.8570
52 C1b C 21.7202 -17.1859
53 C1b C 20.5530 -17.8724
54 C1b C 19.3700 -17.2013
55 O6a O 20.7632 -20.3167
56 C1b C 25.1593 -22.6110
57 C1a C 25.1524 -23.9524
58 C1a C 29.1427 -16.0890
BOND 62
1 9 1 1
2 10 11 1
3 11 6 2
4 6 7 1
5 7 8 2
6 1 2 1
7 2 3 2
8 3 4 1
9 4 5 1
10 5 1 2
11 8 9 1
12 9 10 2
13 22 34 2
14 15 17 1
15 20 35 1 #Down
16 16 18 1
17 16 36 1 #Down
18 17 19 1
19 16 37 1 #Up
20 18 20 1
21 19 21 1
22 20 22 1
23 21 27 1
24 22 23 1
25 23 28 1
26 13 24 2
27 15 25 1 #Up
28 17 26 2
29 39 38 1 #Up
30 39 40 1
31 39 41 1
32 40 42 1
33 40 43 1 #Down
34 41 44 1
35 42 45 1
36 42 46 1 #Up
37 44 47 1 #Up
38 46 48 1
39 46 49 1
40 44 45 1
41 14 38 1 #Down
42 12 50 1 #Up
43 29 51 1
44 51 52 1
45 52 53 1
46 12 13 1
47 53 54 1
48 27 28 1
49 28 29 1 #Down
50 29 30 1
51 30 31 1
52 27 31 1 #Up
53 12 14 1
54 30 55 2
55 27 32 1 #Down
56 21 56 1 #Down
57 13 15 1
58 56 57 1
59 23 33 1 #Down
60 14 16 1
61 36 58 1
62 4 54 1
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