KEGG   DRUG: TelithromycinHelp
Entry
D01078                      Drug                                   

Name
Telithromycin (JAN/USAN/INN);
TEL;
Ketek (TN)
Product
Formula
C43H65N5O10
Exact mass
811.4731
Mol weight
812.0037
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01551  Macrolide antibiotic
Cyp substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
 DG01522  CYP3A4 inhibitor
Remark
Same as: 
ATC code: 
Activity
Antibacterial, Protein biosynthesis inhibitor
Comment
Ketolide
Target
50S ribosomal subunit
  Pathway
Ribosome
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551], CYP2D6 [HSA:1565]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA15 Telithromycin
      D01078  Telithromycin (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Telithromycin
    D01078  Telithromycin (JAN/USAN/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   50S subunit inhibitor
    Macrolides
     Telithromycin
      D01078  Telithromycin (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C8
   Telithromycin
    D01078  Telithromycin (JAN/USAN/INN)
  CYP2D6
   Telithromycin
    D01078  Telithromycin (JAN/USAN/INN)
  CYP3A
   Telithromycin
    D01078  Telithromycin (JAN/USAN/INN)
 CYP substrates
  CYP2D6
   Telithromycin
    D01078  Telithromycin (JAN/USAN/INN)
  CYP3A4
   Telithromycin
    D01078  Telithromycin (JAN/USAN/INN)
  CYP3A5
   Telithromycin
    D01078  Telithromycin (JAN/USAN/INN)
  CYP3A7
   Telithromycin
    D01078  Telithromycin (JAN/USAN/INN)
Antibacterials [br08350.html]
 D01078
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01078
BRITE hierarchy
Other DBs
CAS: 
191114-48-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        58
            1   C8y C     9.6207  -13.9475
            2   N5x N     9.9703  -15.3170
            3   C8x C    11.3140  -15.3182
            4   N4y N    11.7920  -14.0625
            5   C8x C    10.7482  -13.2113
            6   C8x C     6.1283  -11.9268
            7   N5x N     6.1283  -13.2742
            8   C8x C     7.3099  -13.9478
            9   C8y C     8.4637  -13.2742
            10  C8x C     8.4637  -11.9268
            11  C8x C     7.3099  -11.2599
            12  C1y C    23.2549  -17.0489
            13  C5x C    22.0756  -17.7310
            14  C1y C    23.2549  -15.6908
            15  C1y C    22.0756  -19.0890
            16  C1z C    22.0756  -15.0154
            17  C7x C    20.9164  -19.7711
            18  C1x C    22.0756  -13.6518
            19  O7x O    19.7315  -19.0890
            20  C1y C    20.9164  -12.9754
            21  C1y C    19.7315  -17.7310
            22  C5x C    19.7315  -13.6518
            23  C1y C    19.7315  -15.0154
            24  O5x O    20.9146  -17.0518
            25  C1a C    23.2549  -19.7675
            26  O6a O    20.9177  -21.1311
            27  C1z C    18.5546  -17.0496
            28  C1y C    18.5519  -15.6908
            29  N1y N    16.5168  -15.2793
            30  C7x C    15.7218  -16.3778
            31  O7x O    16.5213  -17.4661
            32  C1a C    18.1989  -18.3499
            33  C1a C    18.5427  -14.3422
            34  O5x O    18.5505  -12.9683
            35  C1a C    20.9177  -11.6182
            36  O2a O    22.7497  -13.5310
            37  C1a C    23.5926  -14.3978
            38  O2a O    24.9452  -15.5328
            39  C1y C    26.4577  -16.0816
            40  C1y C    27.6539  -15.4080
            41  O2x O    26.4354  -17.4462
            42  C1y C    28.8181  -16.0953
            43  O1a O    27.6674  -14.0542
            44  C1y C    27.6255  -18.1506
            45  C1x C    28.8164  -17.4701
            46  N1c N    29.9987  -15.4248
            47  C1a C    27.6201  -19.5076
            48  C1a C    31.1704  -16.1131
            49  C1a C    30.0046  -14.0687
            50  C1a C    24.4431  -17.7279
            51  C1b C    16.5079  -13.9228
            52  C1b C    15.3329  -13.2522
            53  C1b C    14.1667  -13.9382
            54  C1b C    12.9846  -13.2676
            55  O6a O    14.3767  -16.3806
            56  C1b C    18.7693  -18.6730
            57  C1a C    18.7624  -20.0134
            58  C1a C    22.7495  -12.1562
BOND        62
            1     9   1 1
            2    10  11 1
            3    11   6 2
            4     6   7 1
            5     7   8 2
            6     1   2 1
            7     2   3 2
            8     3   4 1
            9     4   5 1
            10    5   1 2
            11    8   9 1
            12    9  10 2
            13   22  34 2
            14   15  17 1
            15   20  35 1 #Down
            16   16  18 1
            17   16  36 1 #Up
            18   17  19 1
            19   16  37 1 #Down
            20   18  20 1
            21   19  21 1
            22   20  22 1
            23   21  27 1
            24   22  23 1
            25   23  28 1
            26   13  24 2
            27   15  25 1 #Up
            28   17  26 2
            29   39  38 1 #Up
            30   39  40 1
            31   39  41 1
            32   40  42 1
            33   40  43 1 #Down
            34   41  44 1
            35   42  45 1
            36   42  46 1 #Up
            37   44  47 1 #Up
            38   46  48 1
            39   46  49 1
            40   44  45 1
            41   14  38 1 #Down
            42   12  50 1 #Up
            43   29  51 1
            44   51  52 1
            45   52  53 1
            46   12  13 1
            47   53  54 1
            48   27  28 1
            49   28  29 1 #Down
            50   29  30 1
            51   30  31 1
            52   27  31 1
            53   12  14 1
            54   30  55 2
            55   27  32 1 #Down
            56   21  56 1 #Down
            57   13  15 1
            58   56  57 1
            59   23  33 1 #Up
            60   14  16 1
            61   36  58 1
            62    4  54 1

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