KEGG   DRUG: D01079Help
Entry
D01079                      Drug                                   

Name
Tigecycline (JAN/USAN);
Tygacil (TN)
Product
Formula
C29H39N5O8
Exact mass
585.2799
Mol weight
585.6487
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial [bacterial protein synthesis inhibitor] [DS:H00300 H00301 H00302 H00304 H00311]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Glycylcyclines
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Tetracyclines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA12 Tigecycline
      D01079  Tigecycline (JAN/USAN)
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Tigecycline
    D01079  Tigecycline (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   612  Acting mainly on gram-negative bacteria
    6129  Others
     D01079  Tigecycline (JAN/USAN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Tetracyclines
     Tigecycline
      D01079  Tigecycline (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 Inhbitors
  CYP2C9
   Tigecycline
    D01079  Tigecycline (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
220620-09-7
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
KCF data Show

ATOM        42
            1   C8x C    22.5581  -17.5708
            2   C8y C    22.5581  -18.9726
            3   C8y C    23.7759  -19.6700
            4   C8y C    23.7759  -16.8663
            5   C8y C    24.9868  -17.5708
            6   C8y C    24.9809  -18.9726
            7   C5x C    26.1929  -19.6751
            8   C1x C    26.2048  -16.8715
            9   C1y C    27.4167  -17.5811
            10  C2y C    27.4741  -18.9792
            11  C2y C    28.6096  -19.6857
            12  C1x C    28.6348  -16.8893
            13  C1y C    29.8333  -17.6029
            14  C1z C    29.8132  -19.0006
            15  C5x C    31.0148  -19.7134
            16  C2y C    32.2362  -19.0353
            17  C2y C    32.2563  -17.6378
            18  C1y C    31.0549  -16.9179
            19  N1b N    21.3433  -19.6707
            20  C5a C    20.1351  -18.9738
            21  C1b C    18.9204  -19.6718
            22  N1b N    17.7051  -18.9751
            23  C1d C    16.4905  -19.6732
            24  O5a O    20.1343  -17.5720
            25  O1a O    33.4812  -16.9507
            26  C5a C    33.4410  -19.7501
            27  O5a O    33.4908  -21.1519
            28  N1a N    34.6661  -19.0703
            29  N1c N    31.0750  -15.5161
            30  C1a C    32.2999  -14.8361
            31  C1a C    29.8773  -14.8013
            32  O5x O    26.1902  -21.0770
            33  O1a O    28.5991  -21.0876
            34  O5x O    30.9947  -21.1152
            35  O1a O    23.7791  -21.0719
            36  C1a C    15.2750  -18.9763
            37  C1a C    15.7740  -20.8817
            38  C1a C    17.1759  -20.8817
            39  O1a O    29.7999  -20.3956
            40  N1c N    23.8327  -15.4644
            41  C1a C    25.0409  -14.7554
            42  C1a C    22.6110  -14.7786
BOND        45
            1    19  20 1
            2     4   1 1
            3    20  21 1
            4    21  22 1
            5     1   2 2
            6    22  23 1
            7     9  10 1
            8    20  24 2
            9    10  11 2
            10   17  25 1
            11   11  14 1
            12   16  26 1
            13   13  12 1
            14   26  27 2
            15   12   9 1
            16   26  28 1
            17    2   3 1
            18   18  29 1 #Down
            19    3   6 2
            20   29  30 1
            21    5   6 1
            22   29  31 1
            23    6   7 1
            24    7  32 2
            25    7  10 1
            26   11  33 1
            27    9   8 1
            28   15  34 2
            29   13  14 1
            30    3  35 1
            31   14  15 1
            32   23  36 1
            33   15  16 1
            34   23  37 1
            35   16  17 2
            36   23  38 1
            37   17  18 1
            38   14  39 1 #Down
            39   18  13 1
            40    8   5 1
            41    4  40 1
            42    2  19 1
            43   40  41 1
            44    5   4 2
            45   40  42 1

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