KEGG   DRUG: D01096Help
Entry
D01096                      Drug                                   

Name
Hydroxyzine pamoate (JP16/USP);
Atarax-P (TN);
Vistaril pamoate (TN)
Product
  Generic
HYDOXYZINE PAMOATE (Preferred Pharmaceuticals), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE HYDROCHLORIDE (REMEDYREPACK), HYDROXYZINE PAMOATE (A-S Medication Solutions LLC), HYDROXYZINE PAMOATE (Aidarex Pharmaceuticals LLC), HYDROXYZINE PAMOATE (American Health Packaging), HYDROXYZINE PAMOATE (AvKARE), HYDROXYZINE PAMOATE (Barr Laboratories), HYDROXYZINE PAMOATE (Bryant Ranch Prepack), HYDROXYZINE PAMOATE (Cardinal Health), HYDROXYZINE PAMOATE (Contract Pharmacy Services-PA), HYDROXYZINE PAMOATE (Eon Labs), HYDROXYZINE PAMOATE (H.J. Harkins Company), HYDROXYZINE PAMOATE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), HYDROXYZINE PAMOATE (Lake Erie Medical DBA Quality Care Products LLC), HYDROXYZINE PAMOATE (Mylan Institutional), HYDROXYZINE PAMOATE (NCS HealthCare of KY), HYDROXYZINE PAMOATE (PD-Rx Pharmaceuticals), HYDROXYZINE PAMOATE (PD-Rx Pharmaceuticals), HYDROXYZINE PAMOATE (PD-Rx Pharmaceuticals), HYDROXYZINE PAMOATE (PD-Rx Pharmaceuticals), HYDROXYZINE PAMOATE (Physicians Total Care), HYDROXYZINE PAMOATE (Preferred Pharmaceuticals), HYDROXYZINE PAMOATE (Preferred Pharmaceuticals), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (REMEDYREPACK), HYDROXYZINE PAMOATE (Rebel Distributors Corp), HYDROXYZINE PAMOATE (RedPharm Drug), HYDROXYZINE PAMOATE (Rising Pharmaceuticals), HYDROXYZINE PAMOATE (STAT RX USA LLC), HYDROXYZINE PAMOATE (STAT Rx USA LLC), HYDROXYZINE PAMOATE (STAT Rx USA LLC), HYDROXYZINE PAMOATE (State of Florida DOH Central Pharmacy), HYDROXYZINE PAMOATE (State of Florida DOH Central Pharmacy), HYDROXYZINE PAMOATE (Watson Laboratories)
Formula
C23H16O6. C21H27ClN2O2
Exact mass
762.2708
Mol weight
763.2738
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Tranquilizer [minor]
Remark
Therapeutic category: 
ATC code: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Anxiolytics
Hypnotics
Histamine H1 receptor antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01096  Hydroxyzine pamoate (JP16/USP)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BB Diphenylmethane derivatives
     N05BB01 Hydroxyzine
      D01096  Hydroxyzine pamoate (JP16/USP)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Hydroxyzine
    D01096  Hydroxyzine pamoate (JP16/USP)
 Anxiolytics
  Anxiolytics, Other
   Hydroxyzine
    D01096  Hydroxyzine pamoate (JP16/USP)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Hydroxyzine
    D01096  Hydroxyzine pamoate (JP16/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor [HSA:3269] [KO:K04149]
     Hydroxyzine [ATC:N05BB01]
      D01096  Hydroxyzine pamoate (JP16/USP)
BRITE hierarchy
Other DBs
CAS: 
10246-75-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        55
            1   C8x C    33.9216  -16.0049
            2   C8x C    33.9216  -17.3788
            3   C8x C    35.1113  -18.0656
            4   C8x C    36.3012  -17.3788
            5   C8y C    36.3012  -16.0049
            6   C8y C    35.1113  -15.3180
            7   C8y C    37.4909  -15.3180
            8   C8y C    37.4909  -13.9441
            9   C8y C    36.3012  -13.2573
            10  C8x C    35.1113  -13.9441
            11  C1b C    39.3696  -16.1435
            12  C8y C    40.9559  -15.3280
            13  C8y C    42.1205  -16.0004
            14  C8y C    43.3103  -15.3134
            15  C8x C    43.3103  -13.9396
            16  C8y C    42.1456  -13.2672
            17  C8y C    40.9558  -13.9542
            18  C8x C    42.1205  -17.3742
            19  C8x C    43.3103  -18.0610
            20  C8x C    44.5000  -17.3741
            21  C8x C    44.5000  -16.0003
            22  C6a C    36.3012  -11.8836
            23  O6a O    37.5094  -11.1859
            24  O6a O    35.1299  -11.2073
            25  C6a C    42.1454  -11.8835
            26  O6a O    40.9699  -11.2050
            27  O6a O    43.3494  -11.1881
            28  O1a O    38.6826  -13.2561
            29  O1a O    39.7409  -13.2527
            30  C8x C    22.7711  -15.9341
            31  C8y C    22.7711  -17.3375
            32  C8x C    23.9865  -18.0392
            33  C8x C    25.2019  -17.3375
            34  C8y C    25.2019  -15.9341
            35  C8x C    23.9865  -15.2324
            36  C8x C    27.6326  -17.3375
            37  C8y C    27.6326  -15.9341
            38  C1c C    26.4173  -15.2324
            39  N1y N    26.4173  -13.8290
            40  C1x C    27.6347  -13.1261
            41  C1x C    27.6347  -11.7227
            42  N1y N    26.4193  -11.0210
            43  C1x C    25.2019  -11.7239
            44  C1x C    25.2019  -13.1273
            45  C8x C    28.8481  -18.0392
            46  C8x C    30.0634  -17.3375
            47  C8x C    30.0634  -15.9341
            48  C8x C    28.8481  -15.2324
            49  X   Cl   21.5558  -18.0392
            50  C1b C    26.4193   -9.6188
            51  C1b C    27.6352   -8.9168
            52  O2a O    28.8338   -9.6089
            53  C1b C    30.0239   -8.9220
            54  C1b C    31.2181   -9.6117
            55  O1a O    32.4105   -8.9233
BOND        60
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    6  10 1
            12    7  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   12  17 2
            20   13  18 1
            21   18  19 2
            22   19  20 1
            23   20  21 2
            24   14  21 1
            25    9  22 1
            26   22  23 2
            27   22  24 1
            28   16  25 1
            29   25  26 2
            30   25  27 1
            31    8  28 1
            32   17  29 1
            33   30  31 2
            34   31  32 1
            35   32  33 2
            36   33  34 1
            37   34  35 2
            38   30  35 1
            39   36  37 1
            40   37  38 1
            41   34  38 1
            42   38  39 1
            43   39  40 1
            44   40  41 1
            45   41  42 1
            46   42  43 1
            47   43  44 1
            48   39  44 1
            49   36  45 2
            50   45  46 1
            51   46  47 2
            52   47  48 1
            53   37  48 2
            54   31  49 1
            55   42  50 1
            56   50  51 1
            57   51  52 1
            58   52  53 1
            59   53  54 1
            60   54  55 1

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