KEGG   DRUG: D01103Help
Entry
D01103                      Drug                                   

Name
Trospium chloride (JAN/USAN/INN);
Spasmex (TN);
Spasmoplex (TN)
Product
  Generic
Formula
C25H30NO3. Cl
Exact mass
427.1914
Mol weight
427.9636
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of urinary incontinence
Remark
ATC code: 
Drug group: 
Target
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Structure map
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD09 Trospium
      D01103  Trospium chloride (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Genitourinary Agents
  Antispasmodics, Urinary
   Trospium
    D01103  Trospium chloride (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Trospium
      D01103  Trospium chloride (JAN/USAN/INN)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from ornithine
   Tropane alkaloids
    D01103  Trospium chloride (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
10405-02-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   X   Cl   11.7779  -16.5523 #-
            2   N2y N    14.0700  -15.8200 #+
            3   C1x C    15.1900  -14.9800
            4   C1x C    14.7700  -13.6500
            5   C1x C    13.3700  -13.6500
            6   C1x C    12.9500  -15.0500
            7   O7a O    18.1300  -19.5300
            8   C1y C    17.4300  -18.3400
            9   C1x C    16.3800  -16.8000
            10  C1x C    16.3800  -17.8500
            11  C1y C    14.9100  -16.8000
            12  C1y C    14.8400  -17.8500
            13  C1x C    13.8600  -17.3600
            14  C1x C    13.3700  -18.4800
            15  C7a C    19.5300  -19.5300
            16  O6a O    20.2300  -20.7424
            17  C1d C    20.2300  -18.3176
            18  C8y C    21.8398  -18.3176
            19  C8y C    19.5396  -17.1221
            20  O1a O    20.9300  -17.1051
            21  C8x C    20.2251  -15.9347
            22  C8x C    19.5250  -14.7223
            23  C8x C    18.1250  -14.7224
            24  C8x C    17.4396  -15.9097
            25  C8x C    18.1396  -17.1221
            26  C8x C    22.5497  -19.5468
            27  C8x C    23.9497  -19.5466
            28  C8x C    24.6496  -18.3341
            29  C8x C    23.9397  -17.1049
            30  C8x C    22.5397  -17.1051
BOND        33
            1     3   4 1
            2     8   9 1
            3     8  10 1
            4     9  11 1
            5    10  12 1
            6    11   2 1
            7    11  13 1
            8    12  14 1
            9    12   2 1
            10   13  14 1
            11    8   7 1 #Down
            12    4   5 1
            13    5   6 1
            14    6   2 1
            15    2   3 1
            16    7  15 1
            17   15  16 2
            18   15  17 1
            19   17  18 1
            20   17  19 1
            21   17  20 1
            22   19  21 2
            23   21  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   19  25 1
            28   18  26 2
            29   26  27 1
            30   27  28 2
            31   28  29 1
            32   29  30 2
            33   18  30 1

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