KEGG   DRUG: Trospium chlorideHelp
Entry
D01103                      Drug                                   

Name
Trospium chloride (JAN/USAN/INN);
Spasmex (TN);
Spasmoplex (TN)
Product
  Generic
Formula
C25H30NO3. Cl
Exact mass
427.1914
Mol weight
427.9636
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Remark
ATC code: 
Activity
Overactive bladder agent, Muscarinic acetylcholine receptor antagonist
Comment
Treatment of urinary incontinence
Target
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Salivary secretion
Gastric acid secretion
Interaction
Drug interaction
Structure map
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD09 Trospium
      D01103  Trospium chloride (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Genitourinary Agents
  Antispasmodics, Urinary
   Trospium
    D01103  Trospium chloride (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Trospium
      D01103  Trospium chloride (JAN/USAN/INN)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from ornithine
   Tropane alkaloids
    D01103  Trospium chloride (JAN/USAN/INN)
Endocrine and hormonal agents [br08373.html]
 Other urological agents
  D01103
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01103
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01103
BRITE hierarchy
Other DBs
CAS: 
10405-02-4
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   X   Cl   11.7779  -16.5523 #-
            2   N2y N    14.0700  -15.8200 #+
            3   C1x C    15.1900  -14.9800
            4   C1x C    14.7700  -13.6500
            5   C1x C    13.3700  -13.6500
            6   C1x C    12.9500  -15.0500
            7   O7a O    18.1300  -19.5300
            8   C1y C    17.4300  -18.3400
            9   C1x C    16.3800  -16.8000
            10  C1x C    16.3800  -17.8500
            11  C1y C    14.9100  -16.8000
            12  C1y C    14.8400  -17.8500
            13  C1x C    13.8600  -17.3600
            14  C1x C    13.3700  -18.4800
            15  C7a C    19.5300  -19.5300
            16  O6a O    20.2300  -20.7424
            17  C1d C    20.2300  -18.3176
            18  C8y C    21.8398  -18.3176
            19  C8y C    19.5396  -17.1221
            20  O1a O    20.9300  -17.1051
            21  C8x C    20.2251  -15.9347
            22  C8x C    19.5250  -14.7223
            23  C8x C    18.1250  -14.7224
            24  C8x C    17.4396  -15.9097
            25  C8x C    18.1396  -17.1221
            26  C8x C    22.5497  -19.5468
            27  C8x C    23.9497  -19.5466
            28  C8x C    24.6496  -18.3341
            29  C8x C    23.9397  -17.1049
            30  C8x C    22.5397  -17.1051
BOND        33
            1     3   4 1
            2     8   9 1
            3     8  10 1
            4     9  11 1
            5    10  12 1
            6    11   2 1
            7    11  13 1
            8    12  14 1
            9    12   2 1
            10   13  14 1
            11    8   7 1 #Down
            12    4   5 1
            13    5   6 1
            14    6   2 1
            15    2   3 1
            16    7  15 1
            17   15  16 2
            18   15  17 1
            19   17  18 1
            20   17  19 1
            21   17  20 1
            22   19  21 2
            23   21  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 2
            27   19  25 1
            28   18  26 2
            29   26  27 1
            30   27  28 2
            31   28  29 1
            32   29  30 2
            33   18  30 1

» Japanese version   » Back

DBGET integrated database retrieval system