KEGG   DRUG: Milnacipran hydrochlorideHelp
Entry
D01107                      Drug                                   

Name
Milnacipran hydrochloride (JAN/USAN);
Savella (TN);
Toledomin (TN)
Product
Formula
C15H22N2O. HCl
Exact mass
282.1499
Mol weight
282.8089
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01658  Serotonin and norepinephrine reuptake inhibitor
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)
Comment
selective serotonin norepinephrine reuptake inhibitor (SNRI)
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037];
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
Serotonergic synapse
Interaction
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX17 Milnacipran
      D01107  Milnacipran hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Fibromyalgia Agents
   Milnacipran
    D01107  Milnacipran hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01107  Milnacipran hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Milnacipran
      D01107  Milnacipran hydrochloride (JAN/USAN)
    SLC6A4 (serotonin transporter)
     Milnacipran
      D01107  Milnacipran hydrochloride (JAN/USAN)
Psychiatric agents [br08363.html]
 Antidepressants
  D01107
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01107
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01107
BRITE hierarchy
Other DBs
CAS: 
101152-94-7
PubChem: 
ChEBI: 
ChEMBL: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C8x C    19.8786  -14.8387
            2   C8x C    19.8786  -16.2385
            3   C8x C    21.0938  -16.9384
            4   C8y C    22.3018  -16.2385
            5   C8x C    22.3018  -14.8387
            6   C8x C    21.0938  -14.1388
            7   C5a C    23.7016  -16.2385
            8   C1x C    22.3159  -18.6704
            9   C1y C    23.7157  -18.6704
            10  C1z C    23.0089  -17.4543
            11  C1b C    24.4086  -19.8793
            12  O5a O    23.7645  -14.8387
            13  N1c N    25.1014  -16.2385
            14  C1b C    25.8013  -15.0262
            15  C1b C    25.8013  -17.4506
            16  C1a C    27.2011  -17.4474
            17  C1a C    27.2011  -15.0225
            18  N1a N    25.8084  -19.8837
            19  X   Cl   30.3116  -17.8220
BOND        19
            1     8  10 1
            2    10   9 1
            3     3   4 2
            4     9  11 1 #Up
            5    10   4 1 #Down
            6    10   7 1
            7     4   5 1
            8     7  12 2
            9     5   6 2
            10    7  13 1
            11    6   1 1
            12   13  14 1
            13   13  15 1
            14   15  16 1
            15    1   2 2
            16   14  17 1
            17    2   3 1
            18   11  18 1
            19    8   9 1

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