KEGG   DRUG: D01115Help
Entry
D01115                      Drug                                   

Name
Eplerenone (JAN/USAN/INN);
Inspra (TN)
Product
  Generic
Formula
C24H30O6
Exact mass
414.2042
Mol weight
414.4914
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive: Aldosterone antagonist
Remark
Same as: 
Therapeutic category: 
ATC code: 
Target
mineralocorticoid receptor antagonist [HSA:4306] [KO:K08555]
  Pathway
hsa04960  Aldosterone-regulated sodium reabsorption  
 
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Drug interaction
Structure map
Glucocorticoid and meneralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03D POTASSIUM-SPARING AGENTS
    C03DA Aldosterone antagonists
     C03DA04 Eplerenone
      D01115  Eplerenone (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Potassium-sparing
   Eplerenone
    D01115  Eplerenone (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D01115  Eplerenone (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    mineralocorticoid receptor
     Eplerenone
      D01115  Eplerenone (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Eplerenone
    D01115  Eplerenone (JAN/USAN/INN)
  CYP3A5
   Eplerenone
    D01115  Eplerenone (JAN/USAN/INN)
  CYP3A7
   Eplerenone
    D01115  Eplerenone (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
107724-20-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   C1z C    25.7600  -21.4200
            2   C1z C    24.5000  -22.1200
            3   C1x C    26.8800  -22.1200
            4   O7x O    26.8800  -20.6500
            5   C1x C    24.6400  -20.6500
            6   C1y C    24.5000  -23.4500
            7   C1x C    23.3800  -21.4200
            8   C1a C    23.8700  -20.5800
            9   C1x C    26.8800  -23.4500
            10  C7x C    26.4600  -19.3200
            11  C1x C    25.0600  -19.3200
            12  C1y C    23.3800  -24.1500
            13  C1y C    22.1900  -22.1200
            14  O6a O    27.2300  -18.2700
            15  C1z C    22.1900  -23.4500
            16  C1y C    23.3800  -25.5500
            17  C1z C    21.0000  -24.1500
            18  C1x C    22.1900  -26.1800
            19  C7a C    24.5000  -26.1800
            20  C2y C    21.0000  -25.4800
            21  C1x C    19.8100  -23.4500
            22  C1a C    21.0000  -22.7500
            23  O7a O    25.6900  -25.5500
            24  C2x C    19.8100  -26.1800
            25  C1x C    18.6200  -24.1500
            26  C1a C    26.8800  -26.1800
            27  C5x C    18.6200  -25.4800
            28  O5x O    17.4300  -26.1800
            29  O6a O    24.5000  -27.5800
            30  O2x O    23.4024  -22.8200
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Down
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 1
            13   10  14 2
            14   12  15 1
            15   12  16 1
            16   15  17 1
            17   16  18 1
            18   16  19 1 #Down
            19   17  20 1
            20   17  21 1
            21   17  22 1 #Up
            22   19  23 1
            23   20  24 2
            24   21  25 1
            25   23  26 1
            26   24  27 1
            27   27  28 2
            28    6   9 1
            29   10  11 1
            30   13  15 1
            31   18  20 1
            32   25  27 1
            33   19  29 2
            34   13  30 1 #Down
            35   15  30 1 #Down

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